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Gene Review

Ranbp9  -  RAN binding protein 9

Mus musculus

Synonyms: B-cell antigen receptor Ig beta-associated protein 1, IBAP-1, Ibap1, Ran-binding protein 9, Ran-binding protein M, ...
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High impact information on Ranbp9

  • In the same assay, RanBPM also interacted with the beta(1) integrin cytoplasmic domain [1].
  • We find that RanBPM is phosphorylated on serine residues; phosphorylation of RanBPM is increased by stress stimuli and decreased by treatment with the p38 kinase inhibitor SB203580 [1].
  • Transfection of RanBPM synergizes with LFA-1-mediated adhesion in the transcriptional activation of an AP-1-dependent promoter, indicating that the two proteins interact functionally as well [1].
  • We demonstrate that RanBPM is a peripheral membrane protein and that integrins and RanBPM interact in vitro and in vivo and co-localize at the cell membrane [1].
  • On the cellular level, A704 cells, a human renal carcinoma cell line, transfected with RanBPM exhibit increased migration ability [2].

Biological context of Ranbp9

  • Using the yeast two-hybrid system, we found that MVH interacts with mouse RanBPM, a Ran-GTP binding protein involved in microtubule nucleation [3].
  • The interaction of MVH with RanBPM points to a functional relationship between translational regulation and the microtubule nucleation during meiosis [3].
  • A yeast two-hybrid screen using the last 28 amino acids of the cytoplasmic domain of the neural cell adhesion molecule L1 identified RanBPM as an L1-interacting protein [4].

Anatomical context of Ranbp9

  • RanBPM is predominantly expressed in the testis, especially in maturating spermatocytes [3].
  • L1 antibody patching dramatically changes the subcellular localization of N-RanBPM in transfected COS cells [4].
  • In brain tissue sections, RanBPM is highly expressed in the neurons of cerebral cortex and the cerebellar purkinje cells, in a pattern similar to that described for FMRP [5].

Associations of Ranbp9 with chemical compounds

  • We demonstrate that RanBPM, which itself is not a guanine exchange protein, stimulates Ras activation by recruiting Sos [2].
  • Our data suggest that RanBPM, functioning as an adaptor protein for the MET tyrosine kinase domain, can augment the HGF-MET signaling pathway and that RanBPM overexpression may cause constitutive activation of the Ras signaling pathway [2].
  • Thus, full-sized RanBPM cDNA encodes a long stretch of proline and glutamine residues in the N-terminal region [6].
  • Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex [6].

Physical interactions of Ranbp9


Other interactions of Ranbp9

  • Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein [3].
  • Using yeast two-hybrid system, we identified the Ran-binding protein (RanBPM) as an interactor with the intracytoplasmic domain of p75NTR (p75ICD) [7].

Analytical, diagnostic and therapeutic context of Ranbp9

  • To characterize the mechanism, we searched for RanBPM-binding proteins by using a yeast two-hybrid method and isolated a cDNA encoding the ubiquitin-specific protease USP11 [8].
  • Sequence analysis shows that RanBPM is a multi-domain protein [5].


  1. RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. Denti, S., Sirri, A., Cheli, A., Rogge, L., Innamorati, G., Putignano, S., Fabbri, M., Pardi, R., Bianchi, E. J. Biol. Chem. (2004) [Pubmed]
  2. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. Wang, D., Li, Z., Messing, E.M., Wu, G. J. Biol. Chem. (2002) [Pubmed]
  3. Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein. Shibata, N., Tsunekawa, N., Okamoto-Ito, S., Akasu, R., Tokumasu, A., Noce, T. Mol. Reprod. Dev. (2004) [Pubmed]
  4. RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation. Cheng, L., Lemmon, S., Lemmon, V. J. Neurochem. (2005) [Pubmed]
  5. The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. Menon, R.P., Gibson, T.J., Pastore, A. J. Mol. Biol. (2004) [Pubmed]
  6. Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex. Nishitani, H., Hirose, E., Uchimura, Y., Nakamura, M., Umeda, M., Nishii, K., Mori, N., Nishimoto, T. Gene (2001) [Pubmed]
  7. RanBPM is a novel binding protein for p75NTR. Bai, D., Chen, H., Huang, B.R. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  8. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. Ideguchi, H., Ueda, A., Tanaka, M., Yang, J., Tsuji, T., Ohno, S., Hagiwara, E., Aoki, A., Ishigatsubo, Y. Biochem. J. (2002) [Pubmed]
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