Disease relevance of CTDSP1

• A majority (9 of 15) of T- NHLs (9 peripheral T-cell lymphomas, 2 lymphoblastic T-cell lymphomas, and 4 cases of AILD) expressed HOM-TES-14/SCP-1 [1].
• SCP1 contains four core promoter motifs-the TATA box, initiator (Inr), motif ten element (MTE) and downstream promoter element (DPE)-in a single promoter, and is distinctly stronger than the cytomegalovirus (CMV) IE1 and adenovirus major late (AdML) core promoters both in vitro and in vivo [2].

High impact information on CTDSP1

• Moreover, these results provide a template for the design of specific inhibitors of Scp1 for the study of neuronal stem cell development [3].
• Fcp1 and Scp1 belong to a family of Mg(2+)-dependent phosphoserine (P.Ser)/phosphothreonine (P.Thr)-specific phosphatases [3].
• We recently showed that Scp1 is an evolutionarily conserved regulator of neuronal gene silencing [3].
• Specificity may result from CTD binding to a conserved hydrophobic pocket between the active site and an insertion domain that is unique to Fcp1/Scp1 [4].
• Depletion of SCP1/2/3 enhanced Smad2/3 linker phosphorylation [5].

Biological context of CTDSP1

• Accordingly, SCP1 may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation [6].
• SCP1 and related super core promoters (SCPs) with multiple core promoter motifs will be useful for the biophysical analysis of TFIID binding to DNA, the biochemical investigation of the transcription process and the enhancement of gene expression in cells [2].

Anatomical context of CTDSP1

• In proteins such as the eponymous calponin, IQGAP1, and Scp1, a single CH-domain exists, but there has been some controversy over whether this domain binds to actin filaments [7].

Associations of CTDSP1 with chemical compounds

• Sterol carrier protein 1 (SCP1) (Mr 47 000) participates in the microsomal conversion of squalene to lanosterol, and sterol carrier protein 2 (SCP2) (Mr 13 500) participates in the microsomal conversion of lanosterol to cholesterol [8].

Enzymatic interactions of CTDSP1

• The preferred substrate for SCP1 is RNAP II phosphorylated by TFIIH [6].

References