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Gene Review

Slco1b2  -  solute carrier organic anion transporter...

Rattus norvegicus

Synonyms: Liver-specific organic anion transporter 1, OATP-4, Oatp1b2, Oatp4, Slc21a10, ...
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Disease relevance of Slco1b2


High impact information on Slco1b2

  • The Km value in rat hepatocytes is consistent with Oatp4-mediated transport [2].
  • In both the bile duct ligation model and the cecum ligation and puncture model, mRNA expression levels of rlst-1 were down-regulated [1].
  • Accordingly, Oatp4 protein was significantly down-regulated in CA-fed animals together with Oatp1 and Ntcp [3].
  • Oatp4 messenger RNA (mRNA) levels did not differ significantly between bile salt-fed groups, suggesting a posttranscriptional effect of CA on Oatp4 expression [3].
  • Cofeeding of CA plus UDCA prevented the impairment of (14)C-CA and (14)C-TCA secretion and the down-regulation of Oatp4 [3].

Chemical compound and disease context of Slco1b2


Biological context of Slco1b2

  • The rlst-1 gene is composed of 15 exons and 14 introns [4].
  • In addition, we compared the substrate specificity of Oatp4 to that of Oatp3, which so far has mainly been shown to mediate intestinal bile acid transport [5].
  • The tissue distribution of Oatp4 was almost exclusively expressed in liver in contrast to Oatp1, 2, 3, and 5 [6].
  • The preference of Oatp4 for endogenous compounds coupled with its refractory response to known drug-metabolizing enzyme inducers suggests that Oatp4 may be largely responsible for the homeostasis of endogenous rather than exogenous chemicals, including pharmaceuticals [6].

Anatomical context of Slco1b2


Associations of Slco1b2 with chemical compounds


Analytical, diagnostic and therapeutic context of Slco1b2


  1. Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1. Kakyo, M., Unno, M., Tokui, T., Nakagomi, R., Nishio, T., Iwasashi, H., Nakai, D., Seki, M., Suzuki, M., Naitoh, T., Matsuno, S., Yawo, H., Abe, T. Gastroenterology (1999) [Pubmed]
  2. Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Ismair, M.G., Stieger, B., Cattori, V., Hagenbuch, B., Fried, M., Meier, P.J., Kullak-Ublick, G.A. Gastroenterology (2001) [Pubmed]
  3. Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate. Rost, D., Herrmann, T., Sauer, P., Schmidts, H.L., Stieger, B., Meier, P.J., Stremmel, W., Stiehl, A. Hepatology (2003) [Pubmed]
  4. Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene. Choudhuri, S., Ogura, K., Klaassen, C.D. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  5. Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Cattori, V., van Montfoort, J.E., Stieger, B., Landmann, L., Meijer, D.K., Winterhalter, K.H., Meier, P.J., Hagenbuch, B. Pflugers Arch. (2001) [Pubmed]
  6. Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. Li, N., Hartley, D.P., Cherrington, N.J., Klaassen, C.D. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  7. Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver. Cattori, V., Hagenbuch, B., Hagenbuch, N., Stieger, B., Ha, R., Winterhalter, K.E., Meier, P.J. FEBS Lett. (2000) [Pubmed]
  8. Excretion of fetal biliverdin by the rat placenta-maternal liver tandem. Briz, O., Macias, R.I., Perez, M.J., Serrano, M.A., Marin, J.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
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