Gene Review:
SLCO1B3 - solute carrier organic anion transporter...
Homo sapiens
Synonyms:
HBLRR, LST-2, LST-3TM13, LST2, LST3, ...
Abe,
Unno,
Onogawa,
Tokui,
Kondo,
Nakagomi,
Adachi,
Fujiwara,
Okabe,
Suzuki,
Nunoki,
Sato,
Kakyo,
Nishio,
Sugita,
Asano,
Tanemoto,
Seki,
Date,
Ono,
Kondo,
Shiiba,
Suzuki,
Ohtani,
Shimosegawa,
Iinuma,
Nagura,
Ito,
Matsuno,
Marin,
Mangas,
Martinez-Diez,
El-Mir,
Briz,
Serrano,
König,
Cui,
Nies,
Keppler,
Cui,
König,
Leier,
Buchholz,
Keppler,
- LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Abe, T., Unno, M., Onogawa, T., Tokui, T., Kondo, T.N., Nakagomi, R., Adachi, H., Fujiwara, K., Okabe, M., Suzuki, T., Nunoki, K., Sato, E., Kakyo, M., Nishio, T., Sugita, J., Asano, N., Tanemoto, M., Seki, M., Date, F., Ono, K., Kondo, Y., Shiiba, K., Suzuki, M., Ohtani, H., Shimosegawa, T., Iinuma, K., Nagura, H., Ito, S., Matsuno, S. Gastroenterology (2001)
- Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Cui, Y., König, J., Nies, A.T., Pfannschmidt, M., Hergt, M., Franke, W.W., Alt, W., Moll, R., Keppler, D. Lab. Invest. (2003)
- Sensitivity of bile acid transport by organic anion-transporting polypeptides to intracellular pH. Marin, J.J., Mangas, D., Martinez-Diez, M.C., El-Mir, M.Y., Briz, O., Serrano, M.A. Biochim. Biophys. Acta (2003)
- Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Jung, D., Podvinec, M., Meyer, U.A., Mangelsdorf, D.J., Fried, M., Meier, P.J., Kullak-Ublick, G.A. Gastroenterology (2002)
- Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Letschert, K., Keppler, D., König, J. Pharmacogenetics (2004)
- Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics. Smith, N.F., Marsh, S., Scott-Horton, T.J., Hamada, A., Mielke, S., Mross, K., Figg, W.D., Verweij, J., McLeod, H.L., Sparreboom, A. Clin. Pharmacol. Ther. (2007)
- Molecular determinants in the transport of a bile Acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. Libra, A., Fernetti, C., Lorusso, V., Visigalli, M., Anelli, P.L., Staud, F., Tiribelli, C., Pascolo, L. J. Pharmacol. Exp. Ther. (2006)
- Identification of phalloidin uptake systems of rat and human liver. Meier-Abt, F., Faulstich, H., Hagenbuch, B. Biochim. Biophys. Acta (2004)
- Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Smith, N.F., Acharya, M.R., Desai, N., Figg, W.D., Sparreboom, A. Cancer Biol. Ther. (2005)
- Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. Yamaguchi, H., Okada, M., Akitaya, S., Ohara, H., Mikkaichi, T., Ishikawa, H., Sato, M., Matsuura, M., Saga, T., Unno, M., Abe, T., Mano, N., Hishinuma, T., Goto, J. J. Lipid Res. (2006)
- Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. Tirona, R.G., Leake, B.F., Wolkoff, A.W., Kim, R.B. J. Pharmacol. Exp. Ther. (2003)
- Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. König, J., Cui, Y., Nies, A.T., Keppler, D. J. Biol. Chem. (2000)
- Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. Cui, Y., König, J., Leier, I., Buchholz, U., Keppler, D. J. Biol. Chem. (2001)
- Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. Hirano, M., Maeda, K., Shitara, Y., Sugiyama, Y. J. Pharmacol. Exp. Ther. (2004)
- Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. Tahara, H., Kusuhara, H., Maeda, K., Koepsell, H., Fuse, E., Sugiyama, Y. Drug Metab. Dispos. (2006)
- The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. Vavricka, S.R., Jung, D., Fried, M., Grützner, U., Meier, P.J., Kullak-Ublick, G.A. J. Hepatol. (2004)
- Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Vavricka, S.R., Van Montfoort, J., Ha, H.R., Meier, P.J., Fattinger, K. Hepatology (2002)
- Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Letschert, K., Faulstich, H., Keller, D., Keppler, D. Toxicol. Sci. (2006)
- Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Jigorel, E., Le Vee, M., Boursier-Neyret, C., Parmentier, Y., Fardel, O. Drug Metab. Dispos. (2006)
- Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Yamashiro, W., Maeda, K., Hirouchi, M., Adachi, Y., Hu, Z., Sugiyama, Y. Drug Metab. Dispos. (2006)
- Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Hirano, M., Maeda, K., Shitara, Y., Sugiyama, Y. Drug Metab. Dispos. (2006)