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Gene Review

Slco1a5  -  solute carrier organic anion transporter...

Rattus norvegicus

Synonyms: OATP-3, Oatp1a5, Oatp3, Organic anion-transporting polypeptide 3, Slc21a7, ...
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Disease relevance of Slco1a5


High impact information on Slco1a5


Biological context of Slco1a5


Anatomical context of Slco1a5

  • Reverse transcription-polymerase chain reaction analysis revealed that oatp3 was expressed in TR-CSFB cells and isolated rat choroid plexus, although oatp1 was not detected in either [3].
  • Xenopus laevis oocytes expressing oatp3 exhibited [(3)H]E(1)S uptake activity with a K(m) of 8.09 +/- 2.83 microM and V(max) of 8.02 +/- 0.87 pmol/h/oocyte [3].
  • Moreover, oatp3 is localized at the brush-border membrane of choroid plexus epithelial cells [3].
  • This suggests that oatp2 and oatp3 are multifunctional transporters involved in the transport of thyroid hormones in the brain, retina, liver, and kidney [2].
  • In addition, oatp3 immunostaining was detected predominantly in the optic nerve fiber [1].

Other interactions of Slco1a5


Analytical, diagnostic and therapeutic context of Slco1a5


  1. Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina. Ito, A., Yamaguchi, K., Onogawa, T., Unno, M., Suzuki, T., Nishio, T., Suzuki, T., Sasano, H., Abe, T., Tamai, M. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  2. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. Abe, T., Kakyo, M., Sakagami, H., Tokui, T., Nishio, T., Tanemoto, M., Nomura, H., Hebert, S.C., Matsuno, S., Kondo, H., Yawo, H. J. Biol. Chem. (1998) [Pubmed]
  3. In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate. Ohtsuki, S., Takizawa, T., Takanaga, H., Terasaki, N., Kitazawa, T., Sasaki, M., Abe, T., Hosoya, K., Terasaki, T. Mol. Pharmacol. (2003) [Pubmed]
  4. Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Walters, H.C., Craddock, A.L., Fusegawa, H., Willingham, M.C., Dawson, P.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  5. Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Cattori, V., van Montfoort, J.E., Stieger, B., Landmann, L., Meijer, D.K., Winterhalter, K.H., Meier, P.J., Hagenbuch, B. Pflugers Arch. (2001) [Pubmed]
  6. Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus. Kusuhara, H., He, Z., Nagata, Y., Nozaki, Y., Ito, T., Masuda, H., Meier, P.J., Abe, T., Sugiyama, Y. Pharm. Res. (2003) [Pubmed]
  7. Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression. Béery, E., Middel, P., Bahn, A., Willenberg, H.S., Hagos, Y., Koepsell, H., Bornstein, S.R., Müller, G.A., Burckhardt, G., Steffgen, J. Endocrinology (2003) [Pubmed]
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