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Gene Review

Slco1a1  -  solute carrier organic anion transporter...

Rattus norvegicus

Synonyms: OATP-1, Oatp1, Oatp1a1, Organic anion-transporting polypeptide 1, Slc21a1, ...
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Disease relevance of Slco1a1

  • In conclusion, maternal obstructive cholestasis during the last third of pregnancy does not affect the fetal/neonatal expression of the basolateral bile acid transporters, Ntcp and Oatp1 [1].
  • In addition Oatp1 protein was also reduced by 40+/-13% (P<0.05), whereas all other transporters returned to control values.CONCLUSIONS: In chronic cholangitis only canalicular Mrp2 expression remained down-regulated [2].
  • Thus LPS induced an acute-phase response that included downregulation of ICG uptake by reduction of Oatp1 protein concentration, possibly at a posttranscriptional level [3].

High impact information on Slco1a1


Biological context of Slco1a1

  • Oatp1 mRNA and protein were unchanged in pregnancy and postpartum [7].
  • Although many organic anion transport protein (Oatp) family members have PDZ consensus binding sites at their C termini, the functional significance is unknown [8].
  • M of the quadruple mutant was approximately 62 kDa, confirming that these asparagine residues are sites of glycosylation in Oatp1 [9].
  • The moderate decline in expression of Oatp1, -2 and -4 may explain the unchanged sodium-independent transport of bile acids due to overlapping substrate specificity [10].
  • Impaired sodium-dependent uptake of bile acids has been associated with diminished expression of a basolateral Na(+)/bile acid cotransporter (Ntcp), whereas sodium-independent uptake is maintained despite a down-regulation of the organic anion transporter Oatp1 [10].

Anatomical context of Slco1a1


Associations of Slco1a1 with chemical compounds


Regulatory relationships of Slco1a1


Other interactions of Slco1a1

  • Ntcp mediated high affinity, sodium-dependent transport of [35S]sulfobromophthalein with a Km similar to that of oatp1-mediated transport of [35S]sulfobromophthalein (Km = 3.7 vs. 3.3 muM, respectively) [20].
  • CONCLUSIONS: In rat, liver transport proteins of the Oatp and Mrp family are expressed and regulated in a gender-specific manner according to sexual differences in the hepatic metabolism of steroids and drugs [21].
  • In contrast to the well-characterized Oatp1 and Oatp2, the localization and substrate specificity of the recently cloned Oatp4 have not been investigated in detail [22].
  • Consequently, the aim of our study was to measure the hepatic SI enhancement during Gd-BOPTA perfusion as well as the Oatp and Mrp2 expression in normal and cirrhotic livers [23].
  • Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus [24].

Analytical, diagnostic and therapeutic context of Slco1a1


  1. Maternal cholestasis does not affect the ontogenic pattern of expression of the Na+/taurocholate cotransporting polypeptide (ntcp) in the fetal and neonatal rat liver. Arrese, M., Trauner, M., Ananthanarayanan, M., Boyer, J.L., Suchy, F.J. Hepatology (1998) [Pubmed]
  2. Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis. Geier, A., Dietrich, C.G., Lammert, F., Orth, T., Mayet, W.J., Matern, S., Gartung, C. J. Hepatol. (2002) [Pubmed]
  3. Effects of LPS on transport of indocyanine green and alanine uptake in perfused rat liver. Lund, M., Kang, L., Tygstrup, N., Wolkoff, A.W., Ott, P. Am. J. Physiol. (1999) [Pubmed]
  4. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Ho, R.H., Tirona, R.G., Leake, B.F., Glaeser, H., Lee, W., Lemke, C.J., Wang, Y., Kim, R.B. Gastroenterology (2006) [Pubmed]
  5. Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. Kim, J.Y., Kim, K.H., Lee, J.A., Namkung, W., Sun, A.Q., Ananthanarayanan, M., Suchy, F.J., Shin, D.M., Muallem, S., Lee, M.G. Gastroenterology (2002) [Pubmed]
  6. Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Reichel, C., Gao, B., Van Montfoort, J., Cattori, V., Rahner, C., Hagenbuch, B., Stieger, B., Kamisako, T., Meier, P.J. Gastroenterology (1999) [Pubmed]
  7. Differential regulation of hepatic bile salt and organic anion transporters in pregnant and postpartum rats and the role of prolactin. Cao, J., Huang, L., Liu, Y., Hoffman, T., Stieger, B., Meier, P.J., Vore, M. Hepatology (2001) [Pubmed]
  8. Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. Wang, P., Wang, J.J., Xiao, Y., Murray, J.W., Novikoff, P.M., Angeletti, R.H., Orr, G.A., Lan, D., Silver, D.L., Wolkoff, A.W. J. Biol. Chem. (2005) [Pubmed]
  9. N-glycosylation controls functional activity of Oatp1, an organic anion transporter. Lee, T.K., Koh, A.S., Cui, Z., Pierce, R.H., Ballatori, N. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  10. Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. Geier, A., Dietrich, C.G., Gerloff, T., Haendly, J., Kullak-Ublick, G.A., Stieger, B., Meier, P.J., Matern, S., Gartung, C. Biochim. Biophys. Acta (2003) [Pubmed]
  11. Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake. Guo, G.L., Klaassen, C.D. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  12. Functional characterization of the mouse organic-anion-transporting polypeptide 2. van Montfoort, J.E., Schmid, T.E., Adler, I.D., Meier, P.J., Hagenbuch, B. Biochim. Biophys. Acta (2002) [Pubmed]
  13. Carrier-mediated hepatic uptake of peptidic endothelin antagonists in rats. Akhteruzzaman, S., Kato, Y., Kouzuki, H., Suzuki, H., Hisaka, A., Stieger, B., Meier, P.J., Sugiyama, Y. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  14. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2. Rausch-Derra, L.C., Hartley, D.P., Meier, P.J., Klaassen, C.D. Hepatology (2001) [Pubmed]
  15. Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate. Rost, D., Herrmann, T., Sauer, P., Schmidts, H.L., Stieger, B., Meier, P.J., Stremmel, W., Stiehl, A. Hepatology (2003) [Pubmed]
  16. In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate. Ohtsuki, S., Takizawa, T., Takanaga, H., Terasaki, N., Kitazawa, T., Sasaki, M., Abe, T., Hosoya, K., Terasaki, T. Mol. Pharmacol. (2003) [Pubmed]
  17. Characterization of the transport properties of organic anion transporting polypeptide 1 (oatp1) and Na(+)/taurocholate cotransporting polypeptide (Ntcp): comparative studies on the inhibitory effect of their possible substrates in hepatocytes and cDNA-transfected COS-7 cells. Kouzuki, H., Suzuki, H., Stieger, B., Meier, P.J., Sugiyama, Y. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  18. Hepatic uptake of synthetic chlorogenic acid derivatives by the organic anion transport proteins. Schwab, D., Herling, A.W., Hemmerle, H., Schubert, G., Hagenbuch, B., Burger, H.J. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  19. Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. Li, N., Hartley, D.P., Cherrington, N.J., Klaassen, C.D. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  20. Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Hata, S., Wang, P., Eftychiou, N., Ananthanarayanan, M., Batta, A., Salen, G., Pang, K.S., Wolkoff, A.W. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  21. Gender-specific expression of liver organic anion transporters in rat. Rost, D., Kopplow, K., Gehrke, S., Mueller, S., Friess, H., Ittrich, C., Mayer, D., Stiehl, A. Eur. J. Clin. Invest. (2005) [Pubmed]
  22. Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Cattori, V., van Montfoort, J.E., Stieger, B., Landmann, L., Meijer, D.K., Winterhalter, K.H., Meier, P.J., Hagenbuch, B. Pflugers Arch. (2001) [Pubmed]
  23. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. Planchamp, C., Montet, X., Frossard, J.L., Quadri, R., Stieger, B., Meier, P.J., Ivancevic, M.K., Vallée, J.P., Terrier, F., Pastor, C.M. Investigative radiology. (2005) [Pubmed]
  24. Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus. Kusuhara, H., He, Z., Nagata, Y., Nozaki, Y., Ito, T., Masuda, H., Meier, P.J., Abe, T., Sugiyama, Y. Pharm. Res. (2003) [Pubmed]
  25. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. Kuroda, M., Kobayashi, Y., Tanaka, Y., Itani, T., Mifuji, R., Araki, J., Kaito, M., Adachi, Y. J. Gastroenterol. Hepatol. (2004) [Pubmed]
  26. Ontogenic expression of the Na(+)-independent organic anion transporting polypeptide (oatp) in rat liver and kidney. Dubuisson, C., Cresteil, D., Desrochers, M., Decimo, D., Hadchouel, M., Jacquemin, E. J. Hepatol. (1996) [Pubmed]
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