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Gene Review

Stx6  -  syntaxin 6

Rattus norvegicus

Synonyms: Syntaxin-6
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High impact information on Stx6


Biological context of Stx6

  • We have created an ecdysone-inducible gene expression system in the INS-1 beta-cell line and find that induced expression of a membrane-anchorless, cytosolic Syn6 (called Syn6t), but not full-length Syn6, causes a prominent defect in endosomal delivery to lysosomes, and the TGN, in these cells [2].
  • We take, as an example, the promiscuous SNARE syntaxin 6, a SNARE involved in multiple membrane fusion events [3].

Anatomical context of Stx6

  • Greater than 85% of syntaxin 6 was found in Glut4-containing vesicles, and this t-SNARE exhibited insulin-stimulated movement to the plasma membrane [4].
  • Importantly, we have shown that homotypic fusion requires the function of syntaxin 6 on both donor as well as acceptor membranes, which suggests that t-t-SNARE interactions, either direct or indirect, may be required during fusion of ISG membranes [5].
  • Among the known syntaxins, syntaxin 8 is most homologous to syntaxin 6 which is predominantly associated with the trans-Golgi network (TGN) [6].
  • We also found expression of the vesicle recycling proteins synaptogyrin and syntaxin-6 in the same region of the hair follicle [7].

Other interactions of Stx6

  • Although, syntaxin 6 on ISG membranes is associated with SNAP-25 and SNAP-29/GS32, we could not find evidence that these target (t)-SNARE molecules are involved in homotypic ISG fusion [5].

Analytical, diagnostic and therapeutic context of Stx6


  1. Mannose 6-phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6-positive vesicles. Klumperman, J., Kuliawat, R., Griffith, J.M., Geuze, H.J., Arvan, P. J. Cell Biol. (1998) [Pubmed]
  2. Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells. Kuliawat, R., Kalinina, E., Bock, J., Fricker, L., McGraw, T.E., Kim, S.R., Zhong, J., Scheller, R., Arvan, P. Mol. Biol. Cell (2004) [Pubmed]
  3. Syntaxin 6: the promiscuous behaviour of a SNARE protein. Wendler, F., Tooze, S. Traffic (2001) [Pubmed]
  4. Syntaxin 6 regulates Glut4 trafficking in 3T3-L1 adipocytes. Perera, H.K., Clarke, M., Morris, N.J., Hong, W., Chamberlain, L.H., Gould, G.W. Mol. Biol. Cell (2003) [Pubmed]
  5. Homotypic fusion of immature secretory granules during maturation requires syntaxin 6. Wendler, F., Page, L., Urbé, S., Tooze, S.A. Mol. Biol. Cell (2001) [Pubmed]
  6. Preferential association of syntaxin 8 with the early endosome. Subramaniam, V.N., Loh, E., Horstmann, H., Habermann, A., Xu, Y., Coe, J., Griffiths, G., Hong, W. J. Cell. Sci. (2000) [Pubmed]
  7. Essential components for a glutamatergic synapse between Merkel cell and nerve terminal in rats. Hitchcock, I.S., Genever, P.G., Cahusac, P.M. Neurosci. Lett. (2004) [Pubmed]
  8. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. Nakamura, N., Fukuda, H., Kato, A., Hirose, S. Mol. Biol. Cell (2005) [Pubmed]
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