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Gene Review

BLK  -  BLK proto-oncogene, Src family tyrosine...

Homo sapiens

Synonyms: B lymphocyte kinase, MGC10442, Tyrosine-protein kinase Blk, p55-Blk
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High impact information on BLK

  • Expression of BLK in immature T cells suggests that BLK may play an important role in thymopoiesis [1].
  • Only one of the transcripts corresponds to a known gene, encoding B-lymphocyte specific tyrosine kinase, BLK [2].
  • To examine the effect of exercise and adrenergic blockade on lymphocyte cytokine production, six men ingested either a placebo (control) or an alpha- (prazosin hydrochloride) and beta-adrenoceptor antagonist (timolol malate) capsule (blockade, or BLK) 2 h before performing 19 +/- 1 min of supine bicycle exercise at 78 +/- 3% peak pulmonary uptake [3].
  • BLK had no effect on the resting concentration of stimulated cytokine-positive T and NK lymphocytes or the amount of cytokine they were producing [3].
  • METHODS: Intraoperative radiometric measurements were made with the Ophir Power/Energy Meter (LaserStar Model with silicon detector, Model PD-10) and the International Light Radiometer/Photometer (Model IL 1400 with actinic ultraviolet detector, Model SEL240) with and without UV blocking filters (BLK 270 and Schott types WG-280 and WG-230) [4].

Biological context of BLK

  • Through in vitro protein binding assay, interaction between mDAM1 and BLK was also confirmed [5].
  • Transient coexpression of mDAM1 and BLK showed increased cell death compared to BLK expression alone in NMuMG cells [5].
  • Mouse mammary gland cDNA library was screened to search for BLK-interacting protein using yeast two-hybrid system, and a mouse DNA amplified in mammary carcinoma 1 (mDAM1) was obtained. mDAM1 cDNA contained a full coding region of 678bp encoding 225 amino acids with the predicted molecular mass of 26kDa [5].
  • Six endurance-trained men exercised for 20 minutes at approximately 78% of their peak oxygen consumption (Vo(2)) following ingestion of a placebo (CON) or combined alpha- (prazosin hydrochloride) and beta- (timolol maleate) adrenoceptor antagonists (BLK) [6].

Anatomical context of BLK

  • These results indicate that mDAM1 promotes mammary epithelial cell death and pro-apoptotic function of BLK [5].

Associations of BLK with chemical compounds

  • In BLK, the exercise-induced increase in plasma glucose was abolished (0 minutes: 5.7 +/- 0.3; 20 minutes: 5.7 +/- 0.1 mmol. L(-1)) [6].
  • Free fatty acids (FFA) and glycerol were lower (P <.05) in BLK [6].
  • High BLK I values may result if the specimen being analyzed contains a fluorophore that will compete with the fluorescein-labeled antibody used in the assay [7].
  • When that subject's urine was tested using Abbott TDx drugs-of-abuse assays a number of tests resulted in a MX BKG error and all samples had BLK I values greater than those observed with normal urine specimens [7].

Regulatory relationships of BLK


Other interactions of BLK

  • In BLK, plasma insulin and catecholamines were higher (P <.05), while plasma glucagon was unchanged from CON [6].


  1. Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk. Islam, K.B., Rabbani, H., Larsson, C., Sanders, R., Smith, C.I. J. Immunol. (1995) [Pubmed]
  2. Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. Appel, S., Filter, M., Reis, A., Hennies, H.C., Bergheim, A., Ogilvie, E., Arndt, S., Simmons, A., Lovett, M., Hide, W., Ramsay, M., Reichwald, K., Zimmermann, W., Rosenthal, A. Eur. J. Hum. Genet. (2002) [Pubmed]
  3. Effect of adrenergic blockade on lymphocyte cytokine production at rest and during exercise. Starkie, R.L., Rolland, J., Febbraio, M.A. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  4. Scattered laser radiation and broadband actinic ultraviolet plasma emissions during LADARVision excimer refractive surgery. Bower, K.S., Burka, J.M., Hope, R.J., Franks, J.K., Lyon, T.L., Nelson, B.A., Sliney, D.H. Journal of cataract and refractive surgery. (2005) [Pubmed]
  5. Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells. Lee, S., Ha, S., Chung, M., Kim, Y., Choi, Y. Cancer Lett. (2002) [Pubmed]
  6. Regulation of glucose kinetics during intense exercise in humans: effects of alpha- and beta-adrenergic blockade. Howlett, K.F., Watt, M.J., Hargreaves, M., Febbraio, M.A. Metab. Clin. Exp. (2003) [Pubmed]
  7. Vitamin B2 interference with TDx drugs-of-abuse assays. Kunsman, G.W., Levine, B., Smith, M.L. J. Forensic Sci. (1998) [Pubmed]
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