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Gene Review

Casp7  -  caspase 7

Rattus norvegicus

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Disease relevance of Casp7


High impact information on Casp7


Biological context of Casp7

  • It has been suggested that caspase 7, an apoptosis executioner implicated in cell death proteolysis, is redundant to the main executioner caspase 3 and it is generally believed that it is not present in the brain or present in only minute amounts with highly restricted activity [1].
  • While stress signals associated with perturbations of ER functions such as up-regulation of GRP78 was significantly attenuated, other signaling machinery such as activation of caspase-7 transmitting death signals from ER to other organelles could not be altered [6].
  • After 30 min at 0xg, immunostaining for the enzyme caspase-7 was present in the cytoplasm of many cells concurrently with DNA fragmentation identified by the TUNEL method [7].

Anatomical context of Casp7

  • The activation of caspase 7 protein after TBI, demonstrated by immunoblot by the increase of the active form of caspase 7 peaking 5 days post-injury in the cortex and hippocampus, was found to be up-regulated in both neurons and astrocytes by immunohistochemistry [1].
  • The present study was initiated to determine whether AMPA-receptor-induced DCD in PNs is associated with Bax translocation to the mitochondria, cytochrome C release from the mitochondria, changes in mitochondrial potential, and activation of representative initiator and executor caspases that include caspase-9, caspase-3, and caspase-7 [8].

Other interactions of Casp7

  • In parallel with these findings, Abeta1-40-induced changes in activation of caspase-9, caspase-7, and caspase-3 were inhibited by pretreatment with SF [9].
  • HGF had no effect on apoptotic mediators, such as Fas, Fas-L, or caspase-3 and caspase-7 [10].
  • Our results also show that calpain is related to OGD-mediated proteolysis of caspase-3 and -9 but not of caspase-7 [11].

Analytical, diagnostic and therapeutic context of Casp7


  1. Caspase 7: increased expression and activation after traumatic brain injury in rats. Larner, S.F., McKinsey, D.M., Hayes, R.L., W Wang, K.K. J. Neurochem. (2005) [Pubmed]
  2. Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. He, L., Poblenz, A.T., Medrano, C.J., Fox, D.A. J. Biol. Chem. (2000) [Pubmed]
  3. Definition and redesign of the extended substrate specificity of granzyme B. Harris, J.L., Peterson, E.P., Hudig, D., Thornberry, N.A., Craik, C.S. J. Biol. Chem. (1998) [Pubmed]
  4. Antitumor activity of novel indirubin derivatives in rat tumor model. Kim, S.A., Kim, Y.C., Kim, S.W., Lee, S.H., Min, J.J., Ahn, S.G., Yoon, J.H. Clin. Cancer Res. (2007) [Pubmed]
  5. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Schwartz, P.S., Waxman, D.J. Mol. Pharmacol. (2001) [Pubmed]
  6. Reduction of calcium release from the endoplasmic reticulum could only provide partial neuroprotection against beta-amyloid peptide toxicity. Suen, K.C., Lin, K.F., Elyaman, W., So, K.F., Chang, R.C., Hugon, J. J. Neurochem. (2003) [Pubmed]
  7. Microgravity-induced apoptosis in cultured glial cells. Uva, B.M., Masini, M.A., Sturla, M., Bruzzone, F., Giuliani, M., Tagliafierro, G., Strollo, F. European journal of histochemistry : EJH. (2002) [Pubmed]
  8. AMPA-induced dark cell degeneration of cerebellar Purkinje neurons involves activation of caspases and apparent mitochondrial dysfunction. Strahlendorf, J., Box, C., Attridge, J., Diertien, J., Finckbone, V., Henne, W.M., Medina, M.S., Miles, R., Oomman, S., Schneider, M., Singh, H., Veliyaparambil, M., Strahlendorf, H. Brain Res. (2003) [Pubmed]
  9. Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus. Jin, Y., Fan, Y., Yan, E.Z., Liu, Z., Zong, Z.H., Qi, Z.M. Acta Pharmacol. Sin. (2006) [Pubmed]
  10. The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma. Jeschke, M.G., Bolder, U., Finnerty, C.C., Przkora, R., Müller, U., Maihöfer, R., Thompson, J.C., Wolf, S.E., Herndon, D.N. Surgery (2005) [Pubmed]
  11. Contribution of caspase-mediated apoptosis to the cell death caused by oxygen-glucose deprivation in cortical cell cultures. Malagelada, C., Xifró, X., Miñano, A., Sabriá, J., Rodríguez-Alvarez, J. Neurobiol. Dis. (2005) [Pubmed]
  12. Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD). Tao, Y., Kim, J., Stanley, M., He, Z., Faubel, S., Schrier, R.W., Edelstein, C.L. Kidney Int. (2005) [Pubmed]
  13. Mechanism of cell death of rat cardiac fibroblasts induced by serum depletion. Leicht, M., Marx, G., Karbach, D., Gekle, M., Köhler, T., Zimmer, H.G. Mol. Cell. Biochem. (2003) [Pubmed]
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