Chemical Compound Review:
Mafosfamid 2-[[2-[bis(2- chloroethyl)amino]-2-oxo-1...
Synonyms:
Mafosfamida, Mafosfamide, Mafosfamidum, CHEMBL59990, AG-L-65965, ...
- Amifostine improves the antileukemic therapeutic index of mafosfamide: implications for bone marrow purging. Douay, L., Hu, C., Giarratana, M.C., Bouchet, S., Conlon, J., Capizzi, R.L., Gorin, N.C. Blood (1995)
- Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001). Blaney, S.M., Boyett, J., Friedman, H., Gajjar, A., Geyer, R., Horowtiz, M., Hunt, D., Kieran, M., Kun, L., Packer, R., Phillips, P., Pollack, I.F., Prados, M., Heideman, R. J. Clin. Oncol. (2005)
- High-dose selection with mafosfamide results in sensitivity to DNA cross-linking agents: characterization of hypersensitive cell lines. Fritz, G., Hengstler, J.G., Kaina, B. Cancer Res. (1997)
- Intracavitary chemotherapy with activated cyclophosphamides and simultaneous systemic detoxification with protector thiols in Sarcoma 180 ascites tumor. Wagner, T., Mittendorff, F., Walter, E. Cancer Res. (1986)
- Lysis by activated lymphocytes of melanoma and small cell lung cancer cells surviving in vitro treatment with mafosfamide. Gambacorti-Passerini, C., Radrizzani, M., Erba, E., Fossati, G., Parmiani, G. Cancer Res. (1987)
- Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides. Skorski, T., Nieborowska-Skorska, M., Wlodarski, P., Perrotti, D., Hoser, G., Kawiak, J., Majewski, M., Christensen, L., Iozzo, R.V., Calabretta, B. J. Natl. Cancer Inst. (1997)
- Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisense oligodeoxynucleotides combined with mafosfamide. Skorski, T., Nieborowska-Skorska, M., Barletta, C., Malaguarnera, L., Szcyzlik, C., Chen, S.T., Lange, B., Calabretta, B. J. Clin. Invest. (1993)
- Quantitation of mafosfamide-resistant pre-colony-forming units in allogeneic bone marrow transplantation: relationship with rate of engraftment and evidence for long-lasting reduction in stem cell numbers. Kirkland, M.A., Spencer, A., Davidson, R.J., McDonald, C., Goldman, J.M. Blood (1996)
- Antineoplastic activity of ASTA Z 7557 (INN mafosfamide) in transplanted and autochthonous experimental rodent tumors. Zeller, W.J., Berger, M.R., Matys, R., Schuhmacher, J. Investigational new drugs. (1984)
- Efficacy and toxicity of 4-(2-sulfonatoethylthio)-cyclophosphamide cyclohexylamine salt (ASTA Z 7557, INN mafosfamide) after intraperitoneal administration to mice. Roberts, J.D., Hacker, M.P., Newman, R.A., McCormack, J.J., Krakoff, I.H. Investigational new drugs. (1984)
- Limiting-dilution analysis for the determination of leukemic cell frequencies after bone marrow decontamination with mafosfamide or merocyanine 540. Porcellini, A., Talevi, N., Marchetti-Rossi, M.T., Palazzi, M., Manna, A., Sparaventi, G., Delfini, C., Valentini, M. Blood (1987)
- Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Schwartz, P.S., Waxman, D.J. Mol. Pharmacol. (2001)
- One hundred twenty-five adult patients with primary acute leukemia autografted with marrow purged by mafosfamide: a 10-year single institution experience. Laporte, J.P., Douay, L., Lopez, M., Labopin, M., Jouet, J.P., Lesage, S., Stachowiak, J., Fouillard, L., Isnard, F., Noel-Walter, M.P. Blood (1994)
- T-cell ontogeny after autologous bone marrow transplantation: failure to synthesize interleukin-2 (IL-2) and lack of CD2- and CD3-mediated proliferation by both CD4- and CD8+ cells even in the presence of exogeneous IL-2. Cayeux, S., Meuer, S., Pezzutto, A., Körbling, M., Haas, R., Schulz, R., Dörken, B. Blood (1989)
- Autologous bone marrow transplantation using marrow incubated with Asta Z 7557 in adult acute leukemia. Gorin, N.C., Douay, L., Laporte, J.P., Lopez, M., Mary, J.Y., Najman, A., Salmon, C., Aegerter, P., Stachowiak, J., David, R. Blood (1986)
- In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions. Pieters, R., Loonen, A.H., Huismans, D.R., Broekema, G.J., Dirven, M.W., Heyenbrok, M.W., Hählen, K., Veerman, A.J. Blood (1990)
- Human Monocytes, but not Dendritic Cells Derived from Them, Are Defective in Base Excision Repair and Hypersensitive to Methylating Agents. Briegert, M., Kaina, B. Cancer Res. (2007)
- Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Bunting, K.D., Townsend, A.J. Biochem. Pharmacol. (1998)
- Regulation of early hematopoiesis in serum-deprived cultures of mafosfamide-treated and untreated CD34-enriched bone marrow cells. Ottmann, O.G., Stella, C.C., Eder, M., Reutzel, P., Ströcker, S., Hoelzer, D., Ganser, A. Exp. Hematol. (1991)
- Induction of "in vitro" apoptosis by fludarabine in freshly isolated B-chronic lymphocytic leukemia cells. Zinzani, P.L., Buzzi, M., Farabegoli, P., Tosi, P., Fortuna, A., Visani, G., Martinelli, G., Zaccaria, A., Tura, S. Leuk. Lymphoma (1994)
- Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes. Sreerama, L., Sládek, N.E. Chem. Biol. Interact. (2001)
- Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide. Tsaryk, R., Fabian, K., Thacker, J., Kaina, B. Cancer Lett. (2006)
- Disease-free survival after autologous bone marrow transplantation in patients with acute myelogenous leukemia. Körbling, M., Hunstein, W., Fliedner, T.M., Cayeux, S., Dörken, B., Fehrentz, D., Haas, R., Ho, A.D., Keilholz, U., Knauf, W. Blood (1989)
- Mafosfamide: a new intra-CSF chemotherapy? Chamberlain, M.C. J. Clin. Oncol. (2005)
- Intrathecal mafosfamide: a preclinical pharmacology and phase I trial. Blaney, S.M., Balis, F.M., Berg, S., Arndt, C.A., Heideman, R., Geyer, J.R., Packer, R., Adamson, P.C., Jaeckle, K., Klenke, R., Aikin, A., Murphy, R., McCully, C., Poplack, D.G. J. Clin. Oncol. (2005)