Gene Review:
BMPR1A - bone morphogenetic protein receptor, type IA
Homo sapiens
Synonyms:
10q23del, ACVRLK3, ALK-3, ALK3, Activin receptor-like kinase 3, ...
- Bone morphogenetic protein signaling and growth suppression in colon cancer. Beck, S.E., Jung, B.H., Fiorino, A., Gomez, J., Rosario, E.D., Cabrera, B.L., Huang, S.C., Chow, J.Y., Carethers, J.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Vessels' morphology in SMAD4 and BMPR1A-related juvenile polyposis. Handra-Luca, A., Condroyer, C., de Moncuit, C., Tepper, M., Fléjou, J.F., Thomas, G., Olschwang, S. Am. J. Med. Genet. A (2005)
- Genetic testing in colorectal cancer: who, when, how and why. Davidson, N.O. The Keio journal of medicine (2007)
- Loss of heterozygosity on 10q and mutational status of PTEN and BMPR1A in colorectal primary tumours and metastases. Karoui, M., Tresallet, C., Julie, C., Zimmermann, U., Staroz, F., Brams, A., Muti, C., Boulard, C., Robreau, A.M., Puy, H., Malafosse, R., Penna, C., Pruvot, F.R., Thiery, J.P., Boileau, C., Rougier, P., Nordlinger, B., Radvanyi, F., Franc, B., Hofmann-Radvanyi, H. Br. J. Cancer (2004)
- Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts. Seto, H., Kamekura, S., Miura, T., Yamamoto, A., Chikuda, H., Ogata, T., Hiraoka, H., Oda, H., Nakamura, K., Kurosawa, H., Chug, U.I., Kawaguchi, H., Tanaka, S. J. Clin. Invest. (2004)
- Deletion of PTEN and BMPR1A on chromosome 10q23 is not always associated with juvenile polyposis of infancy. Salviati, L., Patricelli, M., Guariso, G., Sturniolo, G.C., Alaggio, R., Bernardi, F., Zuffardi, O., Tenconi, R. Am. J. Hum. Genet. (2006)
- Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Zhou, X.P., Woodford-Richens, K., Lehtonen, R., Kurose, K., Aldred, M., Hampel, H., Launonen, V., Virta, S., Pilarski, R., Salovaara, R., Bodmer, W.F., Conrad, B.A., Dunlop, M., Hodgson, S.V., Iwama, T., Järvinen, H., Kellokumpu, I., Kim, J.C., Leggett, B., Markie, D., Mecklin, J.P., Neale, K., Phillips, R., Piris, J., Rozen, P., Houlston, R.S., Aaltonen, L.A., Tomlinson, I.P., Eng, C. Am. J. Hum. Genet. (2001)
- BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Waite, K.A., Eng, C. Hum. Mol. Genet. (2003)
- Chromosomal localization of three human genes encoding bone morphogenetic protein receptors. Aström, A.K., Jin, D., Imamura, T., Röijer, E., Rosenzweig, B., Miyazono, K., ten Dijke, P., Stenman, G. Mamm. Genome (1999)
- Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis. Sayed, M.G., Ahmed, A.F., Ringold, J.R., Anderson, M.E., Bair, J.L., Mitros, F.A., Lynch, H.T., Tinley, S.T., Petersen, G.M., Giardiello, F.M., Vogelstein, B., Howe, J.R. Ann. Surg. Oncol. (2002)
- Pathobiology of pulmonary arterial hypertension. Naeije, R., Rondelet, B. Bull. Mem. Acad. R. Med. Belg. (2004)
- Expression of bone morphogenetic proteins in stromal cells from human bone marrow long-term culture. Martinovic, S., Mazic, S., Kisic, V., Basic, N., Jakic-Razumovic, J., Borovecki, F., Batinic, D., Simic, P., Grgurevic, L., Labar, B., Vukicevic, S. J. Histochem. Cytochem. (2004)
- Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Park, C., Lavine, K., Mishina, Y., Deng, C.X., Ornitz, D.M., Choi, K. Development (2006)
- A review of juvenile polyposis syndrome. Chow, E., Macrae, F. J. Gastroenterol. Hepatol. (2005)
- Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells. Inagaki, K., Otsuka, F., Suzuki, J., Kano, Y., Takeda, M., Miyoshi, T., Otani, H., Mimura, Y., Ogura, T., Makino, H. Endocrinology (2006)
- An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors. Harrison, C.A., Gray, P.C., Fischer, W.H., Donaldson, C., Choe, S., Vale, W. J. Biol. Chem. (2004)
- Identification of a novel BMPR1A germline mutation in a Korean juvenile polyposis patient without SMAD4 mutation. Kim, I.J., Park, J.H., Kang, H.C., Kim, K.H., Kim, J.H., Ku, J.L., Kang, S.B., Park, S.Y., Lee, J.S., Park, J.G. Clin. Genet. (2003)
- Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin/transforming growth factor-beta receptors in human pituitary adenomas. Alexander, J.M., Bikkal, H.A., Zervas, N.T., Laws, E.R., Klibanski, A. J. Clin. Endocrinol. Metab. (1996)
- BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis. Gupta, I.R., Macias-Silva, M., Kim, S., Zhou, X., Piscione, T.D., Whiteside, C., Wrana, J.L., Rosenblum, N.D. J. Cell. Sci. (2000)
- ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. Zhang, D., Schwarz, E.M., Rosier, R.N., Zuscik, M.J., Puzas, J.E., O'Keefe, R.J. J. Bone Miner. Res. (2003)
- Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23-->q24 byin situ hybridization and radiation hybrid map ping. Ide, H., Saito-Ohara, F., Ohnami, S., Osada, Y., Ikeuchi, T., Yoshida, T., Terada, M. Cytogenet. Cell Genet. (1998)