Gene Review:
BMPR2 - bone morphogenetic protein receptor, type...
Homo sapiens
Synonyms:
BMP type II receptor, BMP type-2 receptor, BMPR-2, BMPR-II, BMPR3, ...
David K Crockett,
Ebendal,
Bengtsson,
Söderström,
Trembath,
Thomson,
Machado,
Morgan,
Atkinson,
Winship,
Simonneau,
Galie,
Loyd,
Humbert,
Nichols,
Morrell,
Berg,
Manes,
McGaughran,
Pauciulo,
Wheeler,
Bengtsson,
Söderström,
Kylberg,
Charette,
Ebendal,
Newman,
Wheeler,
Lane,
Loyd,
Gaddipati,
Phillips,
Loyd,
Grünig,
Koehler,
Miltenberger-Miltenyi,
Zimmermann,
Gorenflo,
Mereles,
Arnold,
Naust,
Wilkens,
Benz,
von Hippel,
Ulmer,
Kübler,
Katus,
Bartram,
Schranz,
Janssen,
Franklin,
Waller,
Pagliari,
Greene,
- BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives. Humbert, M., Deng, Z., Simonneau, G., Barst, R.J., Sitbon, O., Wolf, M., Cuervo, N., Moore, K.J., Hodge, S.E., Knowles, J.A., Morse, J.H. Eur. Respir. J. (2002)
- Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension. Machado, R.D., James, V., Southwood, M., Harrison, R.E., Atkinson, C., Stewart, S., Morrell, N.W., Trembath, R.C., Aldred, M.A. Circulation (2005)
- Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. Trembath, R.C., Thomson, J.R., Machado, R.D., Morgan, N.V., Atkinson, C., Winship, I., Simonneau, G., Galie, N., Loyd, J.E., Humbert, M., Nichols, W.C., Morrell, N.W., Berg, J., Manes, A., McGaughran, J., Pauciulo, M., Wheeler, L. N. Engl. J. Med. (2001)
- HIV-1 TAT represses transcription of the bone morphogenic protein receptor-2 in U937 monocytic cells. Caldwell, R.L., Gadipatti, R., Lane, K.B., Shepherd, V.L. J. Leukoc. Biol. (2006)
- Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension. Machado, R.D., Aldred, M.A., James, V., Harrison, R.E., Patel, B., Schwalbe, E.C., Gruenig, E., Janssen, B., Koehler, R., Seeger, W., Eickelberg, O., Olschewski, H., Elliott, C.G., Glissmeyer, E., Carlquist, J., Kim, M., Torbicki, A., Fijalkowska, A., Szewczyk, G., Parma, J., Abramowicz, M.J., Galie, N., Morisaki, H., Kyotani, S., Nakanishi, N., Morisaki, T., Humbert, M., Simonneau, G., Sitbon, O., Soubrier, F., Coulet, F., Morrell, N.W., Trembath, R.C. Hum. Mutat. (2006)
- Dyslexia. Talk of two theories. Ramus, F. Nature (2001)
- A randomized controlled trial of Sweet Talk, a text-messaging system to support young people with diabetes. Franklin, V.L., Waller, A., Pagliari, C., Greene, S.A. Diabet. Med. (2006)
- Developing and testing a self-care intervention for older adults in caregiving roles. Teel, C.S., Leenerts, M.H. Nursing research. (2005)
- Mental health. Talk of a lay-off. Munro, R. Nursing times. (2001)
- Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. Newman, J.H., Wheeler, L., Lane, K.B., Loyd, E., Gaddipati, R., Phillips, J.A., Loyd, J.E. N. Engl. J. Med. (2001)
- Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Lane, K.B., Machado, R.D., Pauciulo, M.W., Thomson, J.R., Phillips, J.A., Loyd, J.E., Nichols, W.C., Trembath, R.C. Nat. Genet. (2000)
- Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Hardwick, J.C., Van Den Brink, G.R., Bleuming, S.A., Ballester, I., Van Den Brande, J.M., Keller, J.J., Offerhaus, G.J., Van Deventer, S.J., Peppelenbosch, M.P. Gastroenterology (2004)
- Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. Kleeff, J., Maruyama, H., Ishiwata, T., Sawhney, H., Friess, H., Büchler, M.W., Korc, M. Gastroenterology (1999)
- Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. Foletta, V.C., Lim, M.A., Soosairajah, J., Kelly, A.P., Stanley, E.G., Shannon, M., He, W., Das, S., Massague, J., Bernard, O., Soosairaiah, J. J. Cell Biol. (2003)
- Overexpression of a dominant negative type II bone morphogenetic protein receptor inhibits the growth of human breast cancer cells. Pouliot, F., Blais, A., Labrie, C. Cancer Res. (2003)
- Growth regulation of human prostate cancer cells by bone morphogenetic protein-2. Ide, H., Yoshida, T., Matsumoto, N., Aoki, K., Osada, Y., Sugimura, T., Terada, M. Cancer Res. (1997)
- Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. West, J., Fagan, K., Steudel, W., Fouty, B., Lane, K., Harral, J., Hoedt-Miller, M., Tada, Y., Ozimek, J., Tuder, R., Rodman, D.M. Circ. Res. (2004)
- Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Deng, Z., Morse, J.H., Slager, S.L., Cuervo, N., Moore, K.J., Venetos, G., Kalachikov, S., Cayanis, E., Fischer, S.G., Barst, R.J., Hodge, S.E., Knowles, J.A. Am. J. Hum. Genet. (2000)
- BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension. Machado, R.D., Pauciulo, M.W., Thomson, J.R., Lane, K.B., Morgan, N.V., Wheeler, L., Phillips, J.A., Newman, J., Williams, D., Galiè, N., Manes, A., McNeil, K., Yacoub, M., Mikhail, G., Rogers, P., Corris, P., Humbert, M., Donnai, D., Martensson, G., Tranebjaerg, L., Loyd, J.E., Trembath, R.C., Nichols, W.C. Am. J. Hum. Genet. (2001)
- Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension. Rudarakanchana, N., Flanagan, J.A., Chen, H., Upton, P.D., Machado, R., Patel, D., Trembath, R.C., Morrell, N.W. Hum. Mol. Genet. (2002)
- Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension. Wong, W.K., Knowles, J.A., Morse, J.H. Am. J. Respir. Cell Mol. Biol. (2005)
- Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Yang, X., Long, L., Southwood, M., Rudarakanchana, N., Upton, P.D., Jeffery, T.K., Atkinson, C., Chen, H., Trembath, R.C., Morrell, N.W. Circ. Res. (2005)
- Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9. Vitt, U.A., Mazerbourg, S., Klein, C., Hsueh, A.J. Biol. Reprod. (2002)
- BMP signaling controls PASMC KV channel expression in vitro and in vivo. Young, K.A., Ivester, C., West, J., Carr, M., Rodman, D.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- Identification of a novel mutation in the gene for bone morphogenetic protein receptor II in an Israeli patient with familial primary pulmonary hypertension. Cahn, A., Meiner, V., Leitersdorf, E., Berkman, N. Isr. Med. Assoc. J. (2004)
- Chromosomal localization of three human genes encoding bone morphogenetic protein receptors. Aström, A.K., Jin, D., Imamura, T., Röijer, E., Rosenzweig, B., Miyazono, K., ten Dijke, P., Stenman, G. Mamm. Genome (1999)
- Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells. Inagaki, K., Otsuka, F., Suzuki, J., Kano, Y., Takeda, M., Miyoshi, T., Otani, H., Mimura, Y., Ogura, T., Makino, H. Endocrinology (2006)
- Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. Barbara, N.P., Wrana, J.L., Letarte, M. J. Biol. Chem. (1999)
- Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Liu, F., Ventura, F., Doody, J., Massagué, J. Mol. Cell. Biol. (1995)
- Inhibin is an antagonist of bone morphogenetic protein signaling. Wiater, E., Vale, W. J. Biol. Chem. (2003)
- Bone morphogenetic proteins and their receptors: potential functions in the brain. Ebendal, T., Bengtsson, H., Söderström, S. J. Neurosci. Res. (1998)
- Effects of osteogenic protein-1 (OP-1, BMP-7) on gene expression in cultured medial collateral ligament cells. Tsai, A.D., Yeh, L.C., Lee, J.C. J. Cell. Biochem. (2003)
- Potentiating interactions between morphogenetic protein and neurotrophic factors in developing neurons. Bengtsson, H., Söderström, S., Kylberg, A., Charette, M.F., Ebendal, T. J. Neurosci. Res. (1998)
- HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription. Caldwell, R.L., Lane, K.B., Shepherd, V.L. Arch. Biochem. Biophys. (2006)
- Expanding the phenotype of alveolar capillary dysplasia (ACD). Sen, P., Thakur, N., Stockton, D.W., Langston, C., Bejjani, B.A. J. Pediatr. (2004)
- Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Rosenzweig, B.L., Imamura, T., Okadome, T., Cox, G.N., Yamashita, H., ten Dijke, P., Heldin, C.H., Miyazono, K. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Effect of bone morphogenetic protein 2 (BMP2) on oestradiol and inhibin A production by sheep granulosa cells, and localization of BMP receptors in the ovary by immunohistochemistry. Souza, C.J., Campbell, B.K., McNeilly, A.S., Baird, D.T. Reproduction (2002)
- Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands. Mazerbourg, S., Hsueh, A.J. Hum. Reprod. Update (2006)
- Primary pulmonary hypertension in children may have a different genetic background than in adults. Grünig, E., Koehler, R., Miltenberger-Miltenyi, G., Zimmermann, R., Gorenflo, M., Mereles, D., Arnold, K., Naust, B., Wilkens, H., Benz, A., von Hippel, A., Ulmer, H.E., Kübler, W., Katus, H.A., Bartram, C.R., Schranz, D., Janssen, B. Pediatr. Res. (2004)
- Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension. Cogan, J.D., Vnencak-Jones, C.L., Phillips, J.A., Lane, K.B., Wheeler, L.A., Robbins, I.M., Garrison, G., Hedges, L.K., Loyd, J.E. Genet. Med. (2005)
- High frequency of BMPR2 exonic deletions/duplications in familial pulmonary arterial hypertension. Cogan, J.D., Pauciulo, M.W., Batchman, A.P., Prince, M.A., Robbins, I.M., Hedges, L.K., Stanton, K.C., Wheeler, L.A., Phillips, J.A., Loyd, J.E., Nichols, W.C. Am. J. Respir. Crit. Care Med. (2006)
- Pulmonary hypertension in scleroderma spectrum of disease: lack of bone morphogenetic protein receptor 2 mutations. Morse, J., Barst, R., Horn, E., Cuervo, N., Deng, Z., Knowles, J. J. Rheumatol. (2002)