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Dusp6  -  dual specificity phosphatase 6

Mus musculus

Synonyms: 1300019I03Rik, Dual specificity protein phosphatase 6, MAP kinase phosphatase 3, MKP-3, MKP3, ...
 
 
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Disease relevance of Dusp6

 

High impact information on Dusp6

 

Biological context of Dusp6

  • Enforced cytoplasmic retention of the activated ERK1/2 by the expression of an inactive form of MKP-3 cytoplasmic phosphatase inhibits the cell motility response [5].
  • Cloning and expression of the mouse dual-specificity mitogen-activated protein (MAP) kinase phosphatase Mkp3 during mouse embryogenesis [6].
 

Anatomical context of Dusp6

 

Associations of Dusp6 with chemical compounds

 

Regulatory relationships of Dusp6

  • We further show by applying a specific MAP kinase kinase inhibitor (PD184352) that Pyst1 expression is regulated via the MAPK cascade [4].

References

  1. Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development. Li, C., Scott, D.A., Hatch, E., Tian, X., Mansour, S.L. Development (2007) [Pubmed]
  2. HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis. Lee, J.S., Lee, J.J., Seo, J.S. J. Biol. Chem. (2005) [Pubmed]
  3. MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha. Castelli, M., Camps, M., Gillieron, C., Leroy, D., Arkinstall, S., Rommel, C., Nichols, A. J. Biol. Chem. (2004) [Pubmed]
  4. Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos. Eblaghie, M.C., Lunn, J.S., Dickinson, R.J., Münsterberg, A.E., Sanz-Ezquerro, J.J., Farrell, E.R., Mathers, J., Keyse, S.M., Storey, K., Tickle, C. Curr. Biol. (2003) [Pubmed]
  5. Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility. Tanimura, S., Nomura, K., Ozaki, K., Tsujimoto, M., Kondo, T., Kohno, M. J. Biol. Chem. (2002) [Pubmed]
  6. Cloning and expression of the mouse dual-specificity mitogen-activated protein (MAP) kinase phosphatase Mkp3 during mouse embryogenesis. Klock, A., Herrmann, B.G. Mech. Dev. (2002) [Pubmed]
  7. Inducible expression of a MAP kinase phosphatase-3-GFP chimera specifically blunts fibroblast growth and ras-dependent tumor formation in nude mice. Marchetti, S., Gimond, C., Roux, D., Gothié, E., Pouysségur, J., Pagès, G. J. Cell. Physiol. (2004) [Pubmed]
 
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