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Gene Review

STK10  -  serine/threonine kinase 10

Homo sapiens

Synonyms: LOK, Lymphocyte-oriented kinase, PRO2729, Serine/threonine-protein kinase 10
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High impact information on STK10


Biological context of STK10


Regulatory relationships of STK10

  • These data suggest that MEKK1 and LOK may have opposing roles in regulating the CD28RE/AP1 element [4].

Other interactions of STK10


Analytical, diagnostic and therapeutic context of STK10


  1. Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase. Jang, Y.J., Ma, S., Terada, Y., Erikson, R.L. J. Biol. Chem. (2002) [Pubmed]
  2. LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. Kuramochi, S., Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E., Karasuyama, H. J. Biol. Chem. (1997) [Pubmed]
  3. Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults. Bignell, G., Smith, R., Hunter, C., Stephens, P., Davies, H., Greenman, C., Teague, J., Butler, A., Edkins, S., Stevens, C., O'Meara, S., Parker, A., Avis, T., Barthorpe, S., Brackenbury, L., Buck, G., Clements, J., Cole, J., Dicks, E., Edwards, K., Forbes, S., Gorton, M., Gray, K., Halliday, K., Harrison, R., Hills, K., Hinton, J., Jones, D., Kosmidou, V., Laman, R., Lugg, R., Menzies, A., Perry, J., Petty, R., Raine, K., Shepherd, R., Small, A., Solomon, H., Stephens, Y., Tofts, C., Varian, J., Webb, A., West, S., Widaa, S., Yates, A., Gillis, A.J., Stoop, H.J., van Gurp, R.J., Oosterhuis, J.W., Looijenga, L.H., Futreal, P.A., Wooster, R., Stratton, M.R. Genes Chromosomes Cancer (2006) [Pubmed]
  4. Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells. Tao, L., Wadsworth, S., Mercer, J., Mueller, C., Lynn, K., Siekierka, J., August, A. Biochem. J. (2002) [Pubmed]
  5. Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. Kuramochi, S., Matsuda, Y., Okamoto, M., Kitamura, F., Yonekawa, H., Karasuyama, H. Immunogenetics (1999) [Pubmed]
  6. GLEM/LOK report on proctology practice in Belgium. Results, comments and recommendations. Van Outryve, M., Debongnie, J.C. Acta Gastroenterol. Belg. (2006) [Pubmed]
  7. Variation in gene expression in response to stress in two populations of Fundulus heteroclitus. Picard, D.J., Schulte, P.M. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2004) [Pubmed]
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