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Gene Review

Stk10  -  serine/threonine kinase 10

Mus musculus

Synonyms: Gek1, Lok, Lymphocyte-oriented kinase, Serine/threonine-protein kinase 10, mKIAA4026
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High impact information on Stk10

  • Due to close sequence homology to human Slk and Xenopus laevis xPlkk1, two polo-like kinase kinases, we investigated whether Stk10 might also play a role as a Plk1 activator [1].
  • We have identified a previously cloned but uncharacterized family member termed Stk10, which is a human homolog of murine Lok, a serine/threonine kinase highly expressed in lymphocytes [1].
  • We have identified a new gene, designated lok (lymphocyte-oriented kinase), that encodes a 966-amino acid protein kinase whose catalytic domain at the N terminus shows homology to that of the STE20 family members involved in mitogen-activated protein (MAP) kinase cascades [2].
  • Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes [3].
  • Generation of LOK-deficient mice revealed that the leukocyte-function-associated antigen (LFA-1)/intercellular adhesion molecules (ICAM)-mediated aggregation of mitogen-stimulated T cells was greatly enhanced in the absence of LOK [3].

Biological context of Stk10

  • By virtue of polymorphic CA repeats found in the 3' untranslated region of the mouse Stk10 gene, the Stk10 locus was further pinpointed to chromosome 11 between D11Mit53 and D11Mit84, using the intersubspecific backcross mapping panel [4].
  • The Gek1 cDNA encodes a protein with the consensus sequence of the catalytic domain of protein kinases in its N-terminal region [5].
  • The patterns of expression and the structural features of Gek1 suggest that the gene product is involved in signal transduction or nuclear division of germ cells and other proliferating cells [5].
  • From these data, which agree well with previously recorded cell counts and mitotic indices (Lok, Jansen & Rooij, 1982a; Lok, Weenk & Rooij, 1982b), and from the known cell cycle properties (Lok et al., 1982a), the growth fractions of the various types of undifferentiated spermatogonia during the epithelial cycle could be calculated [6].

Anatomical context of Stk10


Associations of Stk10 with chemical compounds


Other interactions of Stk10

  • These results suggest that LOK is potentially involved in the regulation of LFA-1-mediated lymphocyte adhesion [3].

Analytical, diagnostic and therapeutic context of Stk10


  1. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. Walter, S.A., Cutler, R.E., Martinez, R., Gishizky, M., Hill, R.J. J. Biol. Chem. (2003) [Pubmed]
  2. LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. Kuramochi, S., Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E., Karasuyama, H. J. Biol. Chem. (1997) [Pubmed]
  3. Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. Endo, J., Toyama-Sorimachi, N., Taya, C., Kuramochi-Miyagawa, S., Nagata, K., Kuida, K., Takashi, T., Yonekawa, H., Yoshizawa, Y., Miyasaka, N., Karasuyama, H. FEBS Lett. (2000) [Pubmed]
  4. Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. Kuramochi, S., Matsuda, Y., Okamoto, M., Kitamura, F., Yonekawa, H., Karasuyama, H. Immunogenetics (1999) [Pubmed]
  5. A novel serine/threonine kinase gene, Gek1, is expressed in meiotic testicular germ cells and primordial germ cells. Yanagisawa, M., Mukouyama, Y., Watanabe, T., Obinata, M., Matsui, Y. Mol. Reprod. Dev. (1996) [Pubmed]
  6. Spermatogonial multiplication in the Chinese hamster. III. Labelling indices of undifferentiated spermatogonia throughout the cycle of the seminiferous epithelium. Lok, D., de Rooij, D.G. Cell and tissue kinetics. (1983) [Pubmed]
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