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Gene Review

TCHH  -  trichohyalin

Homo sapiens

Synonyms: THH, THL, TRHY, Trichohyalin
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Disease relevance of TCHH


High impact information on TCHH


Chemical compound and disease context of TCHH


Biological context of TCHH

  • Finally, trichohyalin possesses a pair of functional calcium-binding domains of the EF-hand type at its amino terminus that may be involved in its calcium-dependent postsynthetic processing during terminal differentiation [7].
  • In hair follicles, trichohyalin expression was stable without change from 20 wk estimated gestational age [8].
  • These findings suggest that fetal skin may have different sets of barriers from the second trimester; the immature cornified cell envelope is formed in the early second trimester and the mature cornified cell envelope is formed in the late second or early third trimester when filaggrin and trichohyalin appear [8].
  • SIGNIFICANCE: The weak links in the dentin-adhesive resin-resin composite bonded joint may be the interphase regions between the THL and the adhesive resin and the BHL and dentin [9].
  • The results demonstrated that THH alkaloids induced apoptosis of HL-60 cells though c-myc and NF-kappaB signaling pathways [10].

Anatomical context of TCHH

  • Trichohyalin is an intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis and is a known substrate of transglutaminases [7].
  • Trichohyalin is a major differentiation product of hard keratinizing tissues such as the inner root sheath and medullary cells of the hair follicle and the filiform papillae of the tongue, as well as terminally differentiating epidermal cells [11].
  • Pig tongue epithelium yielded milligram quantities of pure trichohyalin from about 100 g of keratomed epithelium [12].
  • Our data demonstrate that PAD3 is the enzyme that deiminates trichohyalin in the medulla and the Henle layer, indicate that PAD1 and 3 are involved in the hair follicle program of differentiation, and suggest a role for PAD1 and 2 in the physiology of sweat glands and arrector pili muscles [13].
  • Another example of possible NO involvement in HF biology is the postsynthetic modification of trichohyalin in differentiating keratinocytes of the IRS [14].

Associations of TCHH with chemical compounds


Regulatory relationships of TCHH

  • Candidate autoantigens that have been identified include the 44/46 kDa hair-specific keratin (expressed in the precortical zone of anagen hair follicles) and trichohyalin (an important intermediate filament-associated protein) expressed in the inner root sheath of the growing hair follicle [19].

Other interactions of TCHH


Analytical, diagnostic and therapeutic context of TCHH


  1. True histiocytic lymphoma. Levine, E.G., Hanson, C.A., Jaszcz, W., Peterson, B.A. Semin. Oncol. (1991) [Pubmed]
  2. Expression of trichohyalin in dermatological disorders: a comparative study with involucrin and filaggrin by immunohistochemical staining. Lee, S.C., Lee, J.B., Seo, J.J., Kim, Y.P. Acta Derm. Venereol. (1999) [Pubmed]
  3. Existence of trichohyalin-keratohyalin hybrid granules: co-localization of two major intermediate filament-associated proteins in non-follicular epithelia. Manabe, M., O'Guin, W.M. Differentiation (1994) [Pubmed]
  4. Trichohyalin, an intermediate filament-associated protein of the hair follicle. Rothnagel, J.A., Rogers, G.E. J. Cell Biol. (1986) [Pubmed]
  5. The fate of trichohyalin. Sequential post-translational modifications by peptidyl-arginine deiminase and transglutaminases. Tarcsa, E., Marekov, L.N., Andreoli, J., Idler, W.W., Candi, E., Chung, S.I., Steinert, P.M. J. Biol. Chem. (1997) [Pubmed]
  6. Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin. Tarcsa, E., Marekov, L.N., Mei, G., Melino, G., Lee, S.C., Steinert, P.M. J. Biol. Chem. (1996) [Pubmed]
  7. The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein. Lee, S.C., Kim, I.G., Marekov, L.N., O'Keefe, E.J., Parry, D.A., Steinert, P.M. J. Biol. Chem. (1993) [Pubmed]
  8. Expression of differentiation markers during fetal skin development in humans: immunohistochemical studies on the precursor proteins forming the cornified cell envelope. Lee, S.C., Lee, J.B., Kook, J.P., Seo, J.J., Nam, K.I., Park, S.S., Kim, Y.P. J. Invest. Dermatol. (1999) [Pubmed]
  9. Mode of failure in the dentin-adhesive resin-resin composite bonded joint as determined by strength-based (muTBS) and fracture-based (CNSB) mechanical testing. Armstrong, S.R., Keller, J.C., Boyer, D.B. Dental materials : official publication of the Academy of Dental Materials. (2001) [Pubmed]
  10. Involvement of NF-kappaB and c-myc signaling pathways in the apoptosis of HL-60 cells induced by alkaloids of Tripterygium hypoglaucum (levl.) Hutch. Zhuang, W.J., Fong, C.C., Cao, J., Ao, L., Leung, C.H., Cheung, H.Y., Xiao, P.G., Fong, W.F., Yang, M.S. Phytomedicine (2004) [Pubmed]
  11. Human trichohyalin gene is clustered with the genes for other epidermal structural proteins and calcium-binding proteins at chromosomal locus 1q21. Lee, S.C., Wang, M., McBride, O.W., O'Keefe, E.J., Kim, I.G., Steinert, P.M. J. Invest. Dermatol. (1993) [Pubmed]
  12. Trichohyalin: a structural protein of hair, tongue, nail, and epidermis. O'Keefe, E.J., Hamilton, E.H., Lee, S.C., Steinert, P. J. Invest. Dermatol. (1993) [Pubmed]
  13. Peptidylarginine deiminase isoforms are differentially expressed in the anagen hair follicles and other human skin appendages. Nachat, R., Méchin, M.C., Charveron, M., Serre, G., Constans, J., Simon, M. J. Invest. Dermatol. (2005) [Pubmed]
  14. Differential expression of nitric oxide synthases in human scalp epidermal and hair follicle pigmentary units: implications for regulation of melanogenesis. Sowden, H.M., Naseem, K.M., Tobin, D.J. Br. J. Dermatol. (2005) [Pubmed]
  15. Mapping of the trichohyalin gene: co-localization with the profilaggrin, involucrin, and loricrin genes. Fietz, M.J., Rogers, G.E., Eyre, H.J., Baker, E., Callen, D.F., Sutherland, G.R. J. Invest. Dermatol. (1992) [Pubmed]
  16. Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex. Huber, M., Siegenthaler, G., Mirancea, N., Marenholz, I., Nizetic, D., Breitkreutz, D., Mischke, D., Hohl, D. J. Invest. Dermatol. (2005) [Pubmed]
  17. Degree of in vivo inhibition of human gastric and pancreatic lipases by Orlistat (Tetrahydrolipstatin, THL) in the stomach and small intestine. Sternby, B., Hartmann, D., Borgström, B., Nilsson, A. Clinical nutrition (Edinburgh, Scotland) (2002) [Pubmed]
  18. Sequence analysis of a 14.2 kb fragment of Saccharomyces cerevisiae chromosome XIV that includes the ypt53, tRNALeu and gsr m2 genes and four new open reading frames. Garcia-Cantalejo, J.M., Boskovic, J., Jimenez, A. Yeast (1996) [Pubmed]
  19. Characterization of hair follicle antigens targeted by the anti-hair follicle immune response. Tobin, D.J. J. Investig. Dermatol. Symp. Proc. (2003) [Pubmed]
  20. Altered distribution of keratinization markers in epidermolytic hyperkeratosis. Ishida-Yamamoto, A., Iizuka, H., Manabe, M., O'Guin, W.M., Hohl, D., Kartasova, T., Kuroki, T., Roop, D.R., Eady, R.A. Arch. Dermatol. Res. (1995) [Pubmed]
  21. Fine structure of marsupial hairs, with emphasis on trichohyalin and the structure of the inner root sheath. Alibardi, L. J. Morphol. (2004) [Pubmed]
  22. A natural canine homologue of alopecia areata in humans. Tobin, D.J., Gardner, S.H., Luther, P.B., Dunston, S.M., Lindsey, N.J., Olivry, T. Br. J. Dermatol. (2003) [Pubmed]
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