Disease relevance of Molluscum Contagiosum

• A candidate selenoprotein homologous to glutathione peroxidase was deduced from the sequence of molluscum contagiosum, a poxvirus that causes persistent skin neoplasms in children and acquired immunodeficiency syndrome (AIDS) patients [1].
• Measles virus uses CD150 as a receptor and Molluscum contagiosum virus encodes proteins that are homologous to CD150 [2].
• To correlate distributions of EGF-R to specific dermatoses, skin diseases of viral etiology (verruca vulgaris and molluscum contagiosum) were also probed by EGF-R immunolocalization and 125I-EGF binding [3].
• In advanced HIV, when CD4 is below 200/mm3, Pneumocystis carinii pneumonia, toxoplasmosis, progressive multifocal leukoencephalopathy, Mycobacterium avium complex, molluscum contagiosum, and bacillary angiomatosis all increase in incidence [4].
• Keloid scars as a result of CO2 laser for molluscum contagiosum [5].

High impact information on Molluscum Contagiosum

• A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum [6].
• The MC148 CC chemokine from the human poxvirus molluscum contagiosum (MCV) was probed in parallel with viral macrophage inflammatory protein (vMIP)-II encoded by human herpesvirus 8 (HHV8) in 16 classified human chemokine receptors [6].
• Topical cidofovir for severe molluscum contagiosum [7].
• A secreted CC chemokine homolog, encoded by the MC148 gene of molluscum contagiosum virus, potently interfered with the chemotaxis of human monocytes, lymphocytes, and neutrophils in response to a large number of CC and CXC chemokines with diverse receptor specificities [8].
• We report here that equine herpesvirus type 2 E8 protein and molluscum contagiosum virus MC159 protein both show sequence similarity to the death effector domains (DEDs) of the Fas/TNFR1 signaling components FADD and caspase-8 [9].

Chemical compound and disease context of Molluscum Contagiosum

• Complete regression of giant molluscum contagiosum lesions in an HIV-infected patient following combined antiretroviral therapy with saquinavir, zidovudine and lamivudine [10].
• In dermatological surgery, eutectic lidocaine/prilocaine cream offers effective pain relief in children undergoing curettage of molluscum contagiosum lesions, and in adults undergoing split-skin graft harvesting [11].
• Resolution of intractable molluscum contagiosum in a human immunodeficiency virus-infected patient after institution of antiretroviral therapy with ritonavir [12].
• Cantharidin therapy for molluscum contagiosum in children [13].
• Our results question the use of CO2 laser therapy for molluscum contagiosum [5].

Biological context of Molluscum Contagiosum

• The molluscum contagiosum virus (MCV) MC159 protein contains two death effector domains (DEDs) that bind to the DEDs of caspase-8 and FADD and inhibit apoptosis [14].
• The identification and characterization of the gene encoding the DNA polymerase of molluscum contagiosum virus type 1 (MCV-1) was carried out by PCR technology and nucleotide sequence analysis [15].
• Trichloroacetic acid peel of molluscum contagiosum in immunocompromised patients [16].

Anatomical context of Molluscum Contagiosum

• CONCLUSIONS: These results indicate that molluscum contagiosum lesions exhibit an increased proliferation rate of keratinocytes, which is likely to be partially counteracted by accumulation of p53 [17].
• Hyperimmune sera against vaccinia, rabbit-pox and mouse-pox failed to stain the inclusion bodies in molluscum contagiosum lesions [18].
• We evaluated the density and area of Langerhans cells (LC) using S-100 immunohistochemistry in seven atypical molluscum contagiosum [19].

Gene context of Molluscum Contagiosum

• Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function [20].
• The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8 [21].
• In contrast, those with AR-HIES have severe molluscum contagiosum and other viral infections and may develop severe neurological complications [22].
• This was similar to human IL-18BP and the Molluscum contagiosum virus IL-18BP, which also demonstrated higher affinity for human IL-18 [23].
• Molluscum contagiosum virus (MCV) encodes a CC chemokine MC148R which is likely to have been acquired from the host [24].

Analytical, diagnostic and therapeutic context of Molluscum Contagiosum

• Treatment of molluscum contagiosum using a lidocaine/prilocaine cream (EMLA) for analgesia [25].

References