Disease relevance of Keratosis, Seborrheic

• A double labeling method with two levels of tritiated thymidine was used to study 6 patients with seborrheic keratosis, 1 with a fibroepithelial tumor of Pinkus, and 1 with basal cell nevus syndrome manifesting three pits on the palm of the hand [1].
• The mice further develop a benign skin hyperplasia similar to human seborrheic keratosis as opposed to malignant keratocarcinomata observed in skin-specific PS1 'full' knockouts [2].
• To investigate the role of the recently cloned collagenase-3 (MMP-13) in epidermal tumors, we studied samples representing malignant (basal and squamous cell carcinoma, Paget's disease), pre-malignant (Bowen's disease, solar keratosis), and benign (keratoacanthoma, seborrheic keratosis, linear epidermal nevus) tumors [3].
• Using in situ hybridization, we detected strong VEGF mRNA expression in all of 10 squamous cell carcinomas, 13 common warts, 11 seborrheic keratoses, and in 7 of 8 keratoacanthomas studied [4].
• To our knowledge this is the first occurrence of a Leydig cell tumor in a patient with tuberous sclerosis and the second documented case of eruptive seborrheic keratoses (sign of Leser-Trélat) associated with a benign neoplasm [5].

High impact information on Keratosis, Seborrheic

• Cytarabine-induced inflammation in the seborrheic keratoses of Leser-Trélat [6].
• We therefore screened a series of 62 cases of seborrheic keratosis for FGFR3 mutations [7].
• To correlate distributions of EGF-R with in vivo proliferative status, two benign diseases of unknown etiology, seborrheic keratoses and acrochordons (skin tags), were examined using EGF-R immunolocalization and 125I-EGF binding techniques [8].
• Although the skewing of the polymorphism was not corrected by the normal control epidermis in the remaining 33 seborrheic keratosis cases, one of two HUMARA peaks practically disappeared after HhaI digestion in 20 of 33 seborrheic keratosis cases [9].
• IGF-1 receptor expression in non-growth-activated epidermis of long-standing seborrheic keratoses was confined to the basal epidermal layer, as in normal epidermis [10].

Chemical compound and disease context of Keratosis, Seborrheic

• Evaluation of ammonium lactate in the treatment of seborrheic keratoses [11].
• Because epidermal growth factor receptor localization may change in hyperproliferative skin diseases, we compared epidermal growth factor receptor immunolocalization in seborrheic keratoses and acrochordons from women who were or were not pregnant or taking oral sex steroid hormones [12].
• The possible role of retinoid treatment in the resolution of seborrheic keratoses is discussed [13].
• Cutaneous vitamin A levels in seborrheic keratosis, actinic keratosis, and basal cell carcinoma [14].
• Giant seborrheic keratosis on the frontal scalp treated with topical fluorouracil [15].

Biological context of Keratosis, Seborrheic

• Histology of these lesions disclosed seborrheic keratoses, lesions with seborrheic keratosis, and EV changes in the same biopsy specimens and seborrheic keratoses with features of bowenoid dysplasia [16].

Anatomical context of Keratosis, Seborrheic

• The epidermal growth factor receptor concentration was strikingly elevated in suprabasilar keratinocytes of growing seborrheic keratoses and acrochordons from patients with the dysplastic nevus syndrome who were pregnant or taking sex steroid hormones and less elevated in growing seborrheic keratoses from other patients [12].
• In 54 of 325 seborrheic keratoses, trichostasis spinulosa was found within the keratinous cysts and between papillomatous surface keratin, in addition to being present in contiguous hair follicles [17].

Gene context of Keratosis, Seborrheic

• In 11 seborrheic keratoses, no overexpression of cyclin D was observed [18].
• Formalin-fixed and paraffin embedded specimens from normal skin, seborrheic keratoses, and squamous cell carcinomas were reacted with polyclonal antibodies against rat cathepsin L or cystatin a which cross-react to human cathepsin L and cystatin A, respectively [19].
• Staining with antibodies to p53 was slightly increased in IFKs compared with iSKs or non-inflamed seborrheic keratoses [20].
• Statistical analysis revealed significant differences between mean level of Ki-67 expression of malignant (squamous cell carcinoma, basal cell carcinoma), benign (seborrheic keratoses) and premalignant (solar keratoses, keratoacanthomas) lesions (p<0.01) [21].
• Disappearance or significant reduction in intensity of one of two HUMARA alleles was observed after HhaI digestion in seborrheic keratoses, but not in the normal control epidermis [9].

Analytical, diagnostic and therapeutic context of Keratosis, Seborrheic

• Lac-Hydrin 12% lotion significantly reduced the height (elevation) of seborrheic keratoses, and two seborrheic keratoses cleared completely; however, there was no statistically significant difference in the length, color, and surface characteristics between the study group and the control group [11].
• The cytokeratin expression of seborrheic keratosis was studied by means of immunohistochemistry and compared with that of normal human skin [22].
• OBJECTIVE: To compare topical calcipotriene, topical tazarotene, and topical imiquimod with standard cryosurgery in the treatment of seborrheic keratoses [23].

References