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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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TRPC2  -  transient receptor potential cation...

Homo sapiens

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Psychiatry related information on TRPC2


High impact information on TRPC2

  • While encoding an active channel in the mouse, the human TRPC2 appears to be a pseudogene [2].
  • Here we analyzed total RNA samples from brain and testis for presence of TRPC2 a and b and describe the splicing patterns responsible for their formation, as well as those leading to the alpha and beta forms of TRPC2 [2].
  • Co-expression of TRPC2 with other TRPCs did not restore plasma-membrane trafficking [3].
  • We report the molecular cloning of two novel murine TRPC2 splice variants, mTRPC2alpha and mTRPC2beta. mTRPC2alpha RNA is expressed at low levels in many tissues and cell systems, while mTRPC2beta is exclusively and abundantly expressed in the vomeronasal organ (VNO) [3].
  • Furthermore, field potential and single-cell patch-clamp recordings showed that TRPC2 is dispensable for the transduction of MHC peptide ligands by sensory neurons in the basal zone of the VNO [4].

Biological context of TRPC2

  • Additionally for TRPC1, a larger species, and for TRPC2, a smaller species was detected in all three cell lines with sequencing revealing the fragments to contain TRPC sequence, suggesting that they were either products of alternative splicing events or from closely related genes [5].
  • Neurobiology of TRPC2: from gene to behavior [6].
  • The mammalian genome codes for seven TRPCs of which TRPC2 is the largest with the most restricted pattern of expression and has several alternatively spliced variants [7].
  • TRPC2: molecular biology and functional importance [7].
  • This indicates that a previously unrecognized TRPC2-independent signal transduction mechanism in the VNO underlies the sensing of cues required for the formation of this pheromonal recognition memory [4].

Anatomical context of TRPC2


Associations of TRPC2 with chemical compounds


Other interactions of TRPC2

  • TRPC2 coassociated with Epo-R, PLCgamma, and IP(3)R, and the association between TRPC2 and IP(3)R was disrupted in these mutants [9].


  1. The TRPC2 ion channel and pheromone sensing in the accessory olfactory system. Zufall, F. Naunyn Schmiedebergs Arch. Pharmacol. (2005) [Pubmed]
  2. The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. Yildirim, E., Dietrich, A., Birnbaumer, L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Hofmann, T., Schaefer, M., Schultz, G., Gudermann, T. Biochem. J. (2000) [Pubmed]
  4. Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. Kelliher, K.R., Spehr, M., Li, X.H., Zufall, F., Leinders-Zufall, T. Eur. J. Neurosci. (2006) [Pubmed]
  5. Expression of human TRPC genes in the megakaryocytic cell lines MEG01, DAMI and HEL. Berg, L.P., Shamsher, M.K., El-Daher, S.S., Kakkar, V.V., Authi, K.S. FEBS Lett. (1997) [Pubmed]
  6. Neurobiology of TRPC2: from gene to behavior. Zufall, F., Ukhanov, K., Lucas, P., Leinders-Zufall, T. Pflugers Arch. (2005) [Pubmed]
  7. TRPC2: molecular biology and functional importance. Yildirim, E., Birnbaumer, L. Handbook of experimental pharmacology (2007) [Pubmed]
  8. Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells. Pigozzi, D., Tombal, B., Ducret, T., Vacher, P., Gailly, P. Cell Calcium (2004) [Pubmed]
  9. Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R. Tong, Q., Chu, X., Cheung, J.Y., Conrad, K., Stahl, R., Barber, D.L., Mignery, G., Miller, B.A. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
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