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Gene Review

CASP12  -  caspase 12 (gene/pseudogene)

Homo sapiens

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Disease relevance of CASP12


Psychiatry related information on CASP12


High impact information on CASP12


Chemical compound and disease context of CASP12


Biological context of CASP12


Anatomical context of CASP12


Associations of CASP12 with chemical compounds


Regulatory relationships of CASP12

  • Nuclear factor-kappaB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor receptor-associated ligand (TRAIL) [24].

Other interactions of CASP12


Analytical, diagnostic and therapeutic context of CASP12


  1. Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. Hetz, C., Russelakis-Carneiro, M., Maundrell, K., Castilla, J., Soto, C. EMBO J. (2003) [Pubmed]
  2. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Smith, W.W., Jiang, H., Pei, Z., Tanaka, Y., Morita, H., Sawa, A., Dawson, V.L., Dawson, T.M., Ross, C.A. Hum. Mol. Genet. (2005) [Pubmed]
  3. The inflammatory caspases: guardians against infections and sepsis. Scott, A.M., Saleh, M. Cell Death Differ. (2007) [Pubmed]
  4. Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12. Kumar, S., Kasseckert, S., Kostin, S., Abdallah, Y., Schafer, C., Kaminski, A., Reusch, H.P., Piper, H.M., Steinhoff, G., Ladilov, Y. Cardiovasc. Res. (2007) [Pubmed]
  5. Calcium signaling in cancer and vitamin D. Sergeev, I.N. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
  6. Human caspase 12 has acquired deleterious mutations. Fischer, H., Koenig, U., Eckhart, L., Tschachler, E. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  7. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Ji, C., Kaplowitz, N. Gastroenterology (2003) [Pubmed]
  8. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. Hitomi, J., Katayama, T., Eguchi, Y., Kudo, T., Taniguchi, M., Koyama, Y., Manabe, T., Yamagishi, S., Bando, Y., Imaizumi, K., Tsujimoto, Y., Tohyama, M. J. Cell Biol. (2004) [Pubmed]
  9. Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors. Sanges, D., Comitato, A., Tammaro, R., Marigo, V. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R.J., Kominami, E., Momoi, T. Cell Death Differ. (2007) [Pubmed]
  11. Genistein induces Ca2+ -mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells. Sergeev, I.N. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  12. Clofibrate-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation. Matzno, S., Yasuda, S., Kitada, Y., Akiyoshi, T., Tanaka, N., Juman, S., Shinozuka, K., Nakabayashi, T., Matsuyama, K. Life Sci. (2006) [Pubmed]
  13. Comparative genomic analysis of human and chimpanzee proteases. Puente, X.S., Gutiérrez-Fernández, A., Ordóñez, G.R., Hillier, L.W., López-Otín, C. Genomics (2005) [Pubmed]
  14. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Saleh, M., Vaillancourt, J.P., Graham, R.K., Huyck, M., Srinivasula, S.M., Alnemri, E.S., Steinberg, M.H., Nolan, V., Baldwin, C.T., Hotchkiss, R.S., Buchman, T.G., Zehnbauer, B.A., Hayden, M.R., Farrer, L.A., Roy, S., Nicholson, D.W. Nature (2004) [Pubmed]
  15. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Xie, Q., Khaoustov, V.I., Chung, C.C., Sohn, J., Krishnan, B., Lewis, D.E., Yoffe, B. Hepatology (2002) [Pubmed]
  16. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. Yoneda, T., Imaizumi, K., Oono, K., Yui, D., Gomi, F., Katayama, T., Tohyama, M. J. Biol. Chem. (2001) [Pubmed]
  17. Endoplasmic reticulum stress-associated caspase 12 mediates cisplatin-induced LLC-PK1 cell apoptosis. Liu, H., Baliga, R. J. Am. Soc. Nephrol. (2005) [Pubmed]
  18. Execution of BMP-4-induced apoptosis by p53-dependent ER dysfunction in myeloma and B-cell hybridoma cells. Fukuda, N., Saitoh, M., Kobayashi, N., Miyazono, K. Oncogene (2006) [Pubmed]
  19. Endoplasmic reticulum Ca2+ depletion induces endothelial cell apoptosis independently of caspase-12. Nakano, T., Watanabe, H., Ozeki, M., Asai, M., Katoh, H., Satoh, H., Hayashi, H. Cardiovasc. Res. (2006) [Pubmed]
  20. Caspase-12 processing and fragment translocation into nuclei of tunicamycin-treated cells. Fujita, E., Kouroku, Y., Jimbo, A., Isoai, A., Maruyama, K., Momoi, T. Cell Death Differ. (2002) [Pubmed]
  21. Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. Mandic, A., Hansson, J., Linder, S., Shoshan, M.C. J. Biol. Chem. (2003) [Pubmed]
  22. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. Rao, R.V., Hermel, E., Castro-Obregon, S., del Rio, G., Ellerby, L.M., Ellerby, H.M., Bredesen, D.E. J. Biol. Chem. (2001) [Pubmed]
  23. Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids. Das, A., Banik, N.L., Ray, S.K. Int. J. Cancer (2006) [Pubmed]
  24. Nuclear factor-kappaB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor receptor-associated ligand (TRAIL). Robbins, M.A., Maksumova, L., Pocock, E., Chantler, J.K. Endocrinology (2003) [Pubmed]
  25. ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP). Kuang, E., Wan, Q., Li, X., Xu, H., Liu, Q., Qi, Y. J. Cell. Physiol. (2005) [Pubmed]
  26. Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells. Pigozzi, D., Tombal, B., Ducret, T., Vacher, P., Gailly, P. Cell Calcium (2004) [Pubmed]
  27. TNF-alpha-mediated cardiomyocyte apoptosis involves caspase-12 and calpain. Bajaj, G., Sharma, R.K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  28. Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells. Luthra, S., Fardin, B., Dong, J., Hertzog, D., Kamjoo, S., Gebremariam, S., Butani, V., Narayanan, R., Mungcal, J.K., Kuppermann, B.D., Kenney, M.C. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
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