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Gene Review

ZNF85  -  zinc finger protein 85

Homo sapiens

Synonyms: HPF4, HTF1, Zinc finger protein 85, Zinc finger protein HPF4, Zinc finger protein HTF1
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Disease relevance of ZNF85


High impact information on ZNF85

  • Rapid detection of heparin-induced platelet antibodies with particle gel immunoassay (ID-HPF4) [4].
  • The common epitope of the antibodies 6B4 and HTF1 included residues Tyr94 and Phe76 both of which make critical contacts to the catalytic domain of F.VIIa [2].
  • A total of 1.2 kb has been sequenced and a number of putative regulatory elements identified including glucocorticoid response elements cAMP responsive element, HTF-1, and acute phase signal sequences [5].
  • Heparin-induced platelet aggregation, C-serotonin release assay, and enzyme-linked immmunosorbent assay (ELISA) tests were performed in all the patients to detect the antibodies formed against the complex of heparin and platelet factor 4 (HPF4) [6].
  • HIT II was diagnosed clinically; heparin-induced platelet activation test (HIPA) and serum IgG, IgA, and IgM to heparin-platelet factor 4 complexes (HPF4) were both negative [7].

Chemical compound and disease context of ZNF85


Biological context of ZNF85

  • Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family [1].
  • Generation and expression of the autoantigen, HPF4 complexes, is a key feature for triggering antibody binding and pathogenicity [8].

Associations of ZNF85 with chemical compounds

  • We have examined the effects of seven proteases on human placental tissue factor in Triton X-100, focusing on extracellular and cytoplasmic domains recognized by monoclonal antibodies HTF1, C28 1.1, and C28 2 [9].

Analytical, diagnostic and therapeutic context of ZNF85


  1. Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family. Poncelet, D.A., Bellefroid, E.J., Bastiaens, P.V., Demoitié, M.A., Marine, J.C., Pendeville, H., Alami, Y., Devos, N., Lecocq, P., Ogawa, T., Muller, M., Martial, J.A. DNA Cell Biol. (1998) [Pubmed]
  2. Epitope location on tissue factor determines the anticoagulant potency of monoclonal anti-tissue factor antibodies. Kirchhofer, D., Moran, P., Chiang, N., Kim, J., Riederer, M.A., Eigenbrot, C., Kelley, R.F. Thromb. Haemost. (2000) [Pubmed]
  3. Heparin antibodies and thromboembolism in heparin-coated and noncoated ventricular assist devices. Koster, A., Loebe, M., Sodian, R., Potapov, E.V., Hansen, R., Müller, J., Mertzlufft, F., Crystal, G.J., Kuppe, H., Hetzer, R. J. Thorac. Cardiovasc. Surg. (2001) [Pubmed]
  4. Rapid detection of heparin-induced platelet antibodies with particle gel immunoassay (ID-HPF4). Meyer, O., Salama, A., Pittet, N., Schwind, P. Lancet (1999) [Pubmed]
  5. Cloning and analysis of the human complement factor H gene promoter. Ward, H.M., Higgs, N.H., Blackmore, T.K., Sadlon, T.A., Gordon, D.L. Immunol. Cell Biol. (1997) [Pubmed]
  6. Functional characterization of antibodies against heparin-platelet factor 4 complex in heparin-induced thrombocytopenia patients in Asian-Indians: relevance to inflammatory markers. Kannan, M., Ahmad, S., Ahmad, F., Kale, S., Hoppensteadt, D.A., Fareed, J., Saxena, R. Blood Coagul. Fibrinolysis (2005) [Pubmed]
  7. Heparin-induced thrombocytopenia type II on hemodialysis: switch to danaparoid. Neuhaus, T.J., Goetschel, P., Schmugge, M., Leumann, E. Pediatr. Nephrol. (2000) [Pubmed]
  8. Generation and pathogenicity of anti-platelet factor 4 antibodies: diagnostic implications. Amiral, J., Vissac, A.M. Clin. Appl. Thromb. Hemost. (1999) [Pubmed]
  9. Human placental tissue factor: protease susceptibility of extracellular and cytoplasmic domains. Whittle, S.M., Yoder, S.C., Carson, S.D. Thromb. Res. (1995) [Pubmed]
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