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Gene Review:

MRBC - Monkey RBC receptor

Homo sapiens

Pellegrino, M.A. et al., Patel, P.C. et al., Curry, R.A. et al., Götze, D. et al., Juy, D. et al.

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High impact information on MRBC

This hybridoma recognizes mouse RBC (MRBC) and rat RBC, but not human, rabbit, guinea pig, or SRBC [1].
Receptors for monkey red blood cells (MRBC) that are expressed on subpopulations of human lymphoid cells are coded by genes linked to the major histocompatibility complex (MHC) region [2].
On the other hand, SV40 transformation induced in all the fibroblasts expression of receptors for MRBC [2].
Only 2 of the tumor cell lines and normal fibroblasts from the same individual formed rosettes with MRBC [2].
Several lymphoblastoid cell lines with B cell characteristics, but not two cell lines with T cell characteristics, formed spontaneous rosettes with MRBC [3].

Biological context of MRBC

In addition, we found that the binding sites for MRBC on the above lymphoid cells are highly sensitive to trypsin treatment and can fully be regenerated within 14-15 h when these treated cells are cultured at 37 degrees [4].

Anatomical context of MRBC

Furthermore, by employing a mixed rosette method, lymphocytes carrying both EAC3dmo and FITC-MRBC were encountered [3].
It appears that rosetting with MRBC will provide a new detection marker for human cells classified as B type and a technique for obtaining an enriched T cell population [3].
The percentage of HPL forming rosettes with MRBC paralleled the percentage of HPL exhibiting markers ascribed to human B cells [3].
The present paper describes a study on rosette formation by human lymphoid cells with monkey erythrocytes (MRBC) obtained from two species: African green monkey (Cercopithecus aethiops) and rhesus monkey (Macaca mulata) [4].

Analytical, diagnostic and therapeutic context of MRBC

Incubation of HPL with MRBC and subsequent centrifugation on Ficoll-Isopaque resulted in a highly enriched T cell population at the interface [3].
The B cell nature of CLL cell was determined by classical tests (MRBC-rosette-test, immunofluorescence test for detection of membrane bound immunoglobulins) [5].

References

A self determinant recognizing T cell hybridoma. Juy, D., Barbier, E., Le Guern, C., Cazenave, P.A. J. Immunol. (1982) [Pubmed]
Appearance of receptors for Macaca speciosa red blood cells on human fibroblasts transformed by simian virus 40. Curry, R.A., Pellegrino, M.A., Saxton, R.E., Jensen, F., Ferrone, S. J. Immunol. (1980) [Pubmed]
Rosette formation of human lymphoid cells with monkey red blood cells. Pellegrino, M.A., Ferrone, S., Theofilopoulos, A.N. J. Immunol. (1975) [Pubmed]
Rosette formation by human lymphoid cells with monkey red blood cells. Patel, P.C., Menezes, J., Bourkas, A., Dorval, G., Rivard, G.E., Boulay, G., Stanley, P., Joncas, J.H. Ann. Immunol. (Paris) (1978) [Pubmed]
Comparison of different markers on blood lymphocytes of chronic lymphocytic leukemia. Götze, D., Fiebig, H., Mansfeld, H.W., Mey, U., Schön, E., Uhle, R., Ansorge, S. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. (1985) [Pubmed]

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