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Gene Review

OR51E2  -  olfactory receptor, family 51, subfamily E...

Homo sapiens

Synonyms: HPRAJ, OR51E3P, OR52A2, Olfactory receptor 51E2, Olfactory receptor OR11-16, ...
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Disease relevance of OR51E2

  • Overexpression of PSGR is associated with human prostate intraepithelial neoplasia (PIN) and prostate tumors, suggesting PSGR may play an important role in early prostate cancer development and progression [1].
  • Compared to normal and benign prostatic hyperplasia tissues, the expression of PSGR increased significantly in human prostate intraepithelial neoplasia (PIN) and prostate tumors (approximately 10-fold), especially in early prostate tumors, suggesting PSGR may play an important role in early prostate cancer development and progression [2].
  • The association of PSGR expression with clinical parameters (clinical stages, Gleason scores, recurrent status and metastasis) was also investigated in this study [2].

High impact information on OR51E2


Biological context of OR51E2

  • Exon 1 contains tissue specific regulatory activity for the first promoter of PSGR gene [1].
  • To understand the regulation of tissue-specific expression of human PSGR and its upregulation mechanism in prostate cancers, we characterized the promoter region of PSGR and analyzed the control mechanism for PSGR expression in human prostate tissues/cells [1].

Anatomical context of OR51E2

  • In our control tissues and cell lines nearly all the prostatic and non- prostatic tissues and cell lines expressed PSGR mRNA, whereas only one prostatic neoplastic tissue and the androgen-responsive (LNCaP) and androgen non-responsive (PC3) prostatic cell lines expressed PMEPA1 [5].

Other interactions of OR51E2

  • These data suggest that two functional promoters regulate the transcriptional expression of PSGR in human prostate tissues and PSGR is a new target for IL-6 transcriptional regulation [1].

Analytical, diagnostic and therapeutic context of OR51E2


  1. Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors. Weng, J., Ma, W., Mitchell, D., Zhang, J., Liu, M. J. Cell. Biochem. (2005) [Pubmed]
  2. Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers. Weng, J., Wang, J., Cai, Y., Stafford, L.J., Mitchell, D., Ittmann, M., Liu, M. Int. J. Cancer (2005) [Pubmed]
  3. PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Xu, L.L., Stackhouse, B.G., Florence, K., Zhang, W., Shanmugam, N., Sesterhenn, I.A., Zou, Z., Srikantan, V., Augustus, M., Roschke, V., Carter, K., McLeod, D.G., Moul, J.W., Soppett, D., Srivastava, S. Cancer Res. (2000) [Pubmed]
  4. Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species. Yuan, T.T., Toy, P., McClary, J.A., Lin, R.J., Miyamoto, N.G., Kretschmer, P.J. Gene (2001) [Pubmed]
  5. Prostate - specific G protein couple receptor genes and stag1/pmepa1 in peripheral blood from patients with prostatic cancer. Cardillo, M.R., Di Silverio, F. International journal of immunopathology and pharmacology (2006) [Pubmed]
  6. Identification of a prostate-specific G-protein coupled receptor in prostate cancer. Xia, C., Ma, W., Wang, F., Hua Sb, n.u.l.l., Liu, M. Oncogene (2001) [Pubmed]
  7. The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase. Wang, J., Weng, J., Cai, Y., Penland, R., Liu, M., Ittmann, M. Prostate (2006) [Pubmed]
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