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Gene Review:

OR51E2 - olfactory receptor, family 51, subfamily E...

Homo sapiens

Synonyms: HPRAJ, OR51E3P, OR52A2, Olfactory receptor 51E2, Olfactory receptor OR11-16, ...

Xu, L.L. et al., Weng, J. et al., Weng, J. et al., Cardillo, M.R. et al., Wang, J. et al., et al.

Cardillo, Di Silverio,

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Disease relevance of OR51E2

Overexpression of PSGR is associated with human prostate intraepithelial neoplasia (PIN) and prostate tumors, suggesting PSGR may play an important role in early prostate cancer development and progression [1].
Compared to normal and benign prostatic hyperplasia tissues, the expression of PSGR increased significantly in human prostate intraepithelial neoplasia (PIN) and prostate tumors (approximately 10-fold), especially in early prostate tumors, suggesting PSGR may play an important role in early prostate cancer development and progression [2].
The association of PSGR expression with clinical parameters (clinical stages, Gleason scores, recurrent status and metastasis) was also investigated in this study [2].

High impact information on OR51E2

Here we report the characteristics of the predicted protein sequence of PSGR and its prostate tissue specificity and expression profile in human prostate cancer and matched normal tissues [3].
In situ hybridization assays showed restricted PSGR expression in the epithelial cells of the normal and tumor tissue sections [3].
PSGR, a new prostate tissue-specific gene with homology to the G protein-coupled odorant receptor gene family, has been identified [3].
PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer [3].
We have cloned the full-length cDNA and genomic region of a human prostate specific G-protein coupled receptor with properties characteristic of an olfactory receptor [4].

Biological context of OR51E2

Exon 1 contains tissue specific regulatory activity for the first promoter of PSGR gene [1].
To understand the regulation of tissue-specific expression of human PSGR and its upregulation mechanism in prostate cancers, we characterized the promoter region of PSGR and analyzed the control mechanism for PSGR expression in human prostate tissues/cells [1].

Anatomical context of OR51E2

In our control tissues and cell lines nearly all the prostatic and non- prostatic tissues and cell lines expressed PSGR mRNA, whereas only one prostatic neoplastic tissue and the androgen-responsive (LNCaP) and androgen non-responsive (PC3) prostatic cell lines expressed PMEPA1 [5].

Other interactions of OR51E2

These data suggest that two functional promoters regulate the transcriptional expression of PSGR in human prostate tissues and PSGR is a new target for IL-6 transcriptional regulation [1].

Analytical, diagnostic and therapeutic context of OR51E2

Paired normal and tumor specimens from 52 primary prostate cancers, obtained by laser capture microdissection or manual microdissection, were analyzed for PSGR expression by semiquantitative and real-time PCR assays [3].
Using multiple tissue Northern blots from over 50 different tissues, PSGR expression was restricted to human prostate tissues [3].
In this study, we identified a novel prostate-specific G-protein coupled receptor that interacts with Galpha(12) in our yeast two-hybrid assays [6].
By quantitative RT-PCR all three markers were substantially increased in cancer, with AMACR the most overexpressed (30-fold), followed by PSGR2 (13-fold) and PSGR (10-fold) [7].

References

Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors. Weng, J., Ma, W., Mitchell, D., Zhang, J., Liu, M. J. Cell. Biochem. (2005) [Pubmed]
Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers. Weng, J., Wang, J., Cai, Y., Stafford, L.J., Mitchell, D., Ittmann, M., Liu, M. Int. J. Cancer (2005) [Pubmed]
PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Xu, L.L., Stackhouse, B.G., Florence, K., Zhang, W., Shanmugam, N., Sesterhenn, I.A., Zou, Z., Srikantan, V., Augustus, M., Roschke, V., Carter, K., McLeod, D.G., Moul, J.W., Soppett, D., Srivastava, S. Cancer Res. (2000) [Pubmed]
Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species. Yuan, T.T., Toy, P., McClary, J.A., Lin, R.J., Miyamoto, N.G., Kretschmer, P.J. Gene (2001) [Pubmed]
Prostate - specific G protein couple receptor genes and stag1/pmepa1 in peripheral blood from patients with prostatic cancer. Cardillo, M.R., Di Silverio, F. International journal of immunopathology and pharmacology (2006) [Pubmed]
Identification of a prostate-specific G-protein coupled receptor in prostate cancer. Xia, C., Ma, W., Wang, F., Hua Sb, n.u.l.l., Liu, M. Oncogene (2001) [Pubmed]
The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase. Wang, J., Weng, J., Cai, Y., Penland, R., Liu, M., Ittmann, M. Prostate (2006) [Pubmed]

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OR51E2	Bos taurus
LOC100856052	Canis lupus familiaris
OR51E2	Macaca mulatta
Olfr78	Mus musculus
LOC466344	Pan troglodytes
Olr59	Rattus norvegicus
or51e1	Xenopus (Silurana) tropicalis

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