Disease relevance of Myoc

• During mesangioproliferative glomerulonephritis, an induction of myocilin immunoreactivity was observed [1].
• Myocilin is mutated in some forms of primary open angle glaucoma and affected patients show very high intraocular pressures because of an increase in resistance to aqueous humor outflow [1].
• Myocilin gene expression in the trabecular meshwork of rats in a steroid-induced ocular hypertension model [2].

High impact information on Myoc

• Labeling for myocilin was now observed in activated mesangial cells and areas of glomerular sclerosis [1].
• CONCLUSION: Myocilin is expressed in podocytes of the kidney and induced in mesangial cells during experimental mesangioproliferative glomerulonephritis [1].
• PURPOSE: To isolate the rat Myoc/Tigr gene and investigate changes in its expression pattern in normal eyes and in eyes with either pressure-induced optic nerve damage or optic nerve transection [3].
• Changes in mRNA levels of the Myoc/Tigr gene in the rat eye after experimental elevation of intraocular pressure or optic nerve transection [3].
• RESULTS: The rat Myoc/Tigr gene is 10 kb long and contains three exons [3].

Biological context of Myoc

• The tissue distribution of myocilin transcripts has been analyzed in both humans and mice, and a high level of expression in the retina and skeletal muscle has been reported [4].

Anatomical context of Myoc

• Further study of the expression and role of myocilin in the thyroid is required [4].
• PURPOSE: To investigate the expression pattern of myocilin in the trabecular meshwork of normal and dexamethasone-induced ocular hypertensive rat eyes [2].

Associations of Myoc with chemical compounds

• Despite the IOP elevation, the protein and mRNA levels of myocilin in the trabecular meshwork and around Schlemm's canal in the steroid-treated eyes were not different from those of controls [2].

Analytical, diagnostic and therapeutic context of Myoc

• METHODS: The expression of myocilin in the normal rat kidney and its changes during mesangioproliferative glomerulonephritis were investigated by immunohistochemistry, one- and two-dimensional gel electrophoresis with Western blotting, and reverse transcription-polymerase chain reaction (RT-PCR) [1].
• In parallel cell culture experiments, mRNA for myocilin was detected in cultured murine podocytes and rat mesangial cells [1].
• Molecular cloning and expression profile of rat myocilin [4].
• We isolated rat myocilin cDNA and examined the expression pattern of myocilin, including its expression in endocrine organs, using Northern blot analysis [4].

References