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Gene Review

Myoc  -  myocilin, trabecular meshwork inducible...

Rattus norvegicus

Synonyms: Myocilin, Tigr, Trabecular meshwork-induced glucocorticoid response protein
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Disease relevance of Myoc


High impact information on Myoc


Biological context of Myoc


Anatomical context of Myoc


Associations of Myoc with chemical compounds

  • Despite the IOP elevation, the protein and mRNA levels of myocilin in the trabecular meshwork and around Schlemm's canal in the steroid-treated eyes were not different from those of controls [2].

Analytical, diagnostic and therapeutic context of Myoc


  1. Myocilin is expressed in the glomerulus of the kidney and induced in mesangioproliferative glomerulonephritis. Goldwich, A., Baulmann, D.C., Ohlmann, A., Flügel-Koch, C., Schöcklmann, H., Tamm, E.R. Kidney Int. (2005) [Pubmed]
  2. Myocilin gene expression in the trabecular meshwork of rats in a steroid-induced ocular hypertension model. Sawaguchi, K., Nakamura, Y., Nakamura, Y., Sakai, H., Sawaguchi, S. Ophthalmic Res. (2005) [Pubmed]
  3. Changes in mRNA levels of the Myoc/Tigr gene in the rat eye after experimental elevation of intraocular pressure or optic nerve transection. Ahmed, F., Torrado, M., Johnson, E., Morrison, J., Tomarev, S.I. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  4. Molecular cloning and expression profile of rat myocilin. Taguchi, M., Kanno, H., Kubota, R., Miwa, S., Shishiba, Y., Ozawa, Y. Mol. Genet. Metab. (2000) [Pubmed]
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