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Gene Review

NDPK2  -  nucleoside diphosphate kinase II

Arabidopsis thaliana

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High impact information on NDPK2


Biological context of NDPK2


Anatomical context of NDPK2


Associations of NDPK2 with chemical compounds

  • Further studies indicated that the low enzymatic activity and autophosphorylation level of NDPK2 mutant S199A are shown to be due to a damaged H-bonding with the active histidine residue His197 in the nucleotide-binding pocket [9].
  • To resolve the controversy of whether serine/threonine phosphorylation of NDPK occurs as has been suggested by other NDPK studies, NDPK2 putative phosphorylation site mutants were generated and examined [9].

Other interactions of NDPK2

  • The structure of Arabidopsis NDPK1 and NDPK2 showed that the isoforms share common electrostatic surfaces at the nucleotide-binding site, but the variable C-terminal regions have distinct electrostatic charge distributions [6].
  • These results collectively suggest that NDPK2 appears to participate in auxin-regulated processes, partly through the modulation of auxin transport [7].
  • Expression studies in seedlings revealed that the level of NDPK Ia mRNA, like that of HDH, increases in response to UV-B light [8].


  1. Phytochrome-specific type 5 phosphatase controls light signal flux by enhancing phytochrome stability and affinity for a signal transducer. Ryu, J.S., Kim, J.I., Kunkel, T., Kim, B.C., Cho, D.S., Hong, S.H., Kim, S.H., Fernández, A.P., Kim, Y., Alonso, J.M., Ecker, J.R., Nagy, F., Lim, P.O., Song, P.S., Schäfer, E., Nam, H.G. Cell (2005) [Pubmed]
  2. Phytochrome signalling is mediated through nucleoside diphosphate kinase 2. Choi, G., Yi, H., Lee, J., Kwon, Y.K., Soh, M.S., Shin, B., Luka, Z., Hahn, T.R., Song, P.S. Nature (1999) [Pubmed]
  3. Phytochrome phosphorylation modulates light signaling by influencing the protein-protein interaction. Kim, J.I., Shen, Y., Han, Y.J., Park, J.E., Kirchenbauer, D., Soh, M.S., Nagy, F., Schäfer, E., Song, P.S. Plant Cell (2004) [Pubmed]
  4. NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants. Moon, H., Lee, B., Choi, G., Shin, D., Prasad, D.T., Lee, O., Kwak, S.S., Kim, D.H., Nam, J., Bahk, J., Hong, J.C., Lee, S.Y., Cho, M.J., Lim, C.O., Yun, D.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. NDPK2 as a signal transducer in the phytochrome-mediated light signaling. Shen, Y., Kim, J.I., Song, P.S. J. Biol. Chem. (2005) [Pubmed]
  6. Structural analysis of Arabidopsis thaliana nucleoside diphosphate kinase-2 for phytochrome-mediated light signaling. Im, Y.J., Kim, J.I., Shen, Y., Na, Y., Han, Y.J., Kim, S.H., Song, P.S., Eom, S.H. J. Mol. Biol. (2004) [Pubmed]
  7. A possible role for NDPK2 in the regulation of auxin-mediated responses for plant growth and development. Choi, G., Kim, J.I., Hong, S.W., Shin, B., Choi, G., Blakeslee, J.J., Murphy, A.S., Seo, Y.W., Kim, K., Koh, E.J., Song, P.S., Lee, H. Plant Cell Physiol. (2005) [Pubmed]
  8. UV-responsive genes of arabidopsis revealed by similarity to the Gcn4-mediated UV response in yeast. Zimmermann, S., Baumann, A., Jaekel, K., Marbach, I., Engelberg, D., Frohnmeyer, H. J. Biol. Chem. (1999) [Pubmed]
  9. Autophosphorylation of Arabidopsis nucleoside diphosphate kinase 2 occurs only on its active histidine residue. Shen, Y., Kim, J.I., Song, P.S. Biochemistry (2006) [Pubmed]
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