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Gene Review

MPK6  -  MAP kinase 6

Arabidopsis thaliana

Synonyms: ATMAPK6, ATMPK6, F18O19.10, MAP KINASE 6, MAPK6
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Disease relevance of ATMPK6


High impact information on ATMPK6


Biological context of ATMPK6


Anatomical context of ATMPK6


Associations of ATMPK6 with chemical compounds


Other interactions of ATMPK6

  • Whereas mpk3 and mpk6 knock out plants showed no defects in development or changes in redox control genes, mpk4 null mutant shared several phenotypic and transcript profile features with mekk1 plants [11].
  • In mkk1 mutant plants, the activation by flg22 of MPK4 and two other flg22-induced MAPKs (MPK3 and MPK6) is impaired [12].
  • We show here that MEKK1 is not required for flagellin-triggered activation of MPK3 and MPK6 [13].

Analytical, diagnostic and therapeutic context of ATMPK6

  • Using a C terminus-specific antibody, we show that AtMPK6 is activated in elicitor-treated cell cultures of A. thaliana [9].
  • OXI1 is required for full activation of the mitogen-activated protein kinases (MAPKs) MPK3 and MPK6 after treatment with AOS or elicitor and is necessary for at least two very different AOS-mediated processes: basal resistance to Peronospora parasitica infection, and root hair growth [14].


  1. RNA interference-based (RNAi) suppression of AtMPK6, an Arabidopsis mitogen-activated protein kinase, results in hypersensitivity to ozone and misregulation of AtMPK3. Miles, G.P., Samuel, M.A., Zhang, Y., Ellis, B.E. Environ. Pollut. (2005) [Pubmed]
  2. Silencing of the mitogen-activated protein kinase MPK6 compromises disease resistance in Arabidopsis. Menke, F.L., van Pelt, J.A., Pieterse, C.M., Klessig, D.F. Plant Cell (2004) [Pubmed]
  3. The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis. Teige, M., Scheikl, E., Eulgem, T., Dóczi, R., Ichimura, K., Shinozaki, K., Dangl, J.L., Hirt, H. Mol. Cell (2004) [Pubmed]
  4. A MAPK pathway mediates ethylene signaling in plants. Ouaked, F., Rozhon, W., Lecourieux, D., Hirt, H. EMBO J. (2003) [Pubmed]
  5. Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis. Liu, Y., Zhang, S. Plant Cell (2004) [Pubmed]
  6. Various abiotic stresses rapidly activate Arabidopsis MAP kinases ATMPK4 and ATMPK6. Ichimura, K., Mizoguchi, T., Yoshida, R., Yuasa, T., Shinozaki, K. Plant J. (2000) [Pubmed]
  7. Oxidative stress activates ATMPK6, an Arabidopsis homologue of MAP kinase. Yuasa, T., Ichimura, K., Mizoguchi, T., Shinozaki, K. Plant Cell Physiol. (2001) [Pubmed]
  8. Mapping out the roles of MAP kinases in plant defense. Innes, R.W. Trends Plant Sci. (2001) [Pubmed]
  9. Microbial elicitors induce activation and dual phosphorylation of the Arabidopsis thaliana MAPK 6. Nühse, T.S., Peck, S.C., Hirt, H., Boller, T. J. Biol. Chem. (2000) [Pubmed]
  10. Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6. Desikan, R., Hancock, J.T., Ichimura, K., Shinozaki, K., Neill, S.J. Plant Physiol. (2001) [Pubmed]
  11. A Mitogen-activated Protein Kinase Kinase Kinase Mediates Reactive Oxygen Species Homeostasis in Arabidopsis. Nakagami, H., Soukupov??, H., Schikora, A., Z??rsky, V., Hirt, H. J. Biol. Chem. (2006) [Pubmed]
  12. The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin. M??sz??ros, T., Helfer, A., Hatzimasoura, E., Magyar, Z., Serazetdinova, L., Rios, G., Bard??czy, V., Teige, M., Koncz, C., Peck, S., B??gre, L. Plant J. (2006) [Pubmed]
  13. MEKK1 Is Required for MPK4 Activation and Regulates Tissue-specific and Temperature-dependent Cell Death in Arabidopsis. Ichimura, K., Casais, C., Peck, S.C., Shinozaki, K., Shirasu, K. J. Biol. Chem. (2006) [Pubmed]
  14. OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis. Rentel, M.C., Lecourieux, D., Ouaked, F., Usher, S.L., Petersen, L., Okamoto, H., Knight, H., Peck, S.C., Grierson, C.S., Hirt, H., Knight, M.R. Nature (2004) [Pubmed]
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