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Gene Review

COP9  -  COP9 signalosome complex subunit 8

Arabidopsis thaliana

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High impact information on COP9

  • Therefore COP9, together with COP8 and COP11, defines a novel signaling step in mediating light control of plant development [1].
  • Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase-mediated responses [2].
  • COP10 is part of a nuclear protein complex and capable of directly interacting with both COP1 and the COP9 signalosome [3].
  • A multifaceted role of the COP9 signalosome in cell-signaling processes is hinted at by its associated novel kinase activity, as well as the involvement of its subunits in regulating multiple cell-signaling pathways and cell-cycle progression [4].
  • Moreover, our study reveals a cellular process whereby auxin induces and Rac GTPases mediate the recruitment of nucleoplasmic Aux/IAAs into proteolytically active nuclear protein bodies, into which components of the SCF(TIR1), COP9 signalosome, and 26S proteasome are also recruited [5].

Biological context of COP9


Anatomical context of COP9

  • We have also developed an Arabidopsis protoplast immunolocalization assay and demonstrated that the COP9 complex is localized in the nucleus and that its nuclear localization is not affected by light conditions or tissue types [9].
  • Purification of the COP9 signalosome from porcine spleen, human cell lines, and Arabidopsis thaliana plants [10].

Associations of COP9 with chemical compounds


Physical interactions of COP9


Other interactions of COP9

  • Epistatic analyses with the long hypocotyl hy1, hy2, hy3, hy4, and hy5 mutations suggested that these three loci, similar to COP1 and COP9, act downstream of both phytochromes and a blue light receptor, and probably HY5 as well [15].
  • Thus, we conclude that COP8 encodes subunit 4 of the COP9 signalosome [7].
  • Evidence for FUS6 as a component of the nuclear-localized COP9 complex in Arabidopsis [9].
  • Here, we report the identification of two apparently redundant genes, AJH1 and AJH2, that encode a subunit of the COP9 complex [16].
  • Our data provide evidence that DET1, COP1, and COP9 most likely act as negative regulators of several sets of genes, not just those involved in light-regulated seedling development [17].

Analytical, diagnostic and therapeutic context of COP9


  1. Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. Wei, N., Chamovitz, D.A., Deng, X.W. Cell (1994) [Pubmed]
  2. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Schwechheimer, C., Serino, G., Callis, J., Crosby, W.L., Lyapina, S., Deshaies, R.J., Gray, W.M., Estelle, M., Deng, X.W. Science (2001) [Pubmed]
  3. Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Suzuki, G., Yanagawa, Y., Kwok, S.F., Matsui, M., Deng, X.W. Genes Dev. (2002) [Pubmed]
  4. Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human. Wei, N., Deng, X.W. Trends Genet. (1999) [Pubmed]
  5. RAC GTPases in tobacco and Arabidopsis mediate auxin-induced formation of proteolytically active nuclear protein bodies that contain AUX/IAA proteins. Tao, L.Z., Cheung, A.Y., Nibau, C., Wu, H.M. Plant Cell (2005) [Pubmed]
  6. COP9: a new genetic locus involved in light-regulated development and gene expression in arabidopsis. Wei, N., Deng, X.W. Plant Cell (1992) [Pubmed]
  7. Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome. Serino, G., Tsuge, T., Kwok, S., Matsui, M., Wei, N., Deng, X.W. Plant Cell (1999) [Pubmed]
  8. The COP9 signalosome is essential for development of Drosophila melanogaster. Freilich, S., Oron, E., Kapp, Y., Nevo-Caspi, Y., Orgad, S., Segal, D., Chamovitz, D.A. Curr. Biol. (1999) [Pubmed]
  9. Evidence for FUS6 as a component of the nuclear-localized COP9 complex in Arabidopsis. Staub, J.M., Wei, N., Deng, X.W. Plant Cell (1996) [Pubmed]
  10. Purification of the COP9 signalosome from porcine spleen, human cell lines, and Arabidopsis thaliana plants. Menon, S., Rubio, V., Wang, X., Deng, X.W., Wei, N. Meth. Enzymol. (2005) [Pubmed]
  11. The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responses. Feng, S., Ma, L., Wang, X., Xie, D., Dinesh-Kumar, S.P., Wei, N., Deng, X.W. Plant Cell (2003) [Pubmed]
  12. The COP/DET/FUS proteins-regulators of eukaryotic growth and development. Schwechheimer, C., Deng, X.W. Semin. Cell Dev. Biol. (2000) [Pubmed]
  13. The Arabidopsis inositol 1,3,4-trisphosphate 5/6 kinase, AtItpk-1, is involved in plant photomorphogenesis under red light conditions, possibly via interaction with COP9 signalosome. Qin, Z.X., Chen, Q.J., Tong, Z., Wang, X.C. Plant Physiol. Biochem. (2005) [Pubmed]
  14. The COP9 signalosome interacts with SCF UFO and participates in Arabidopsis flower development. Wang, X., Feng, S., Nakayama, N., Crosby, W.L., Irish, V., Deng, X.W., Wei, N. Plant Cell (2003) [Pubmed]
  15. Arabidopsis COP8, COP10, and COP11 genes are involved in repression of photomorphogenic development in darkness. Wei, N., Kwok, S.F., von Arnim, A.G., Lee, A., McNellis, T.W., Piekos, B., Deng, X.W. Plant Cell (1994) [Pubmed]
  16. Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. Kwok, S.F., Solano, R., Tsuge, T., Chamovitz, D.A., Ecker, J.R., Matsui, M., Deng, X.W. Plant Cell (1998) [Pubmed]
  17. det1, cop1, and cop9 mutations cause inappropriate expression of several gene sets. Mayer, R., Raventos, D., Chua, N.H. Plant Cell (1996) [Pubmed]
  18. Characterization and purification of the mammalian COP9 complex, a conserved nuclear regulator initially identified as a repressor of photomorphogenesis in higher plants. Wei, N., Deng, X.W. Photochem. Photobiol. (1998) [Pubmed]
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