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Gene Review

LDOX  -  leucoanthocyanidin dioxygenase

Arabidopsis thaliana

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High impact information on LDOX


Biological context of LDOX

  • DNA blot analysis was used to screen the Arabidopsis genome for sequences related to FLS and LDOX and to determine the positions of the two clones on the RI map [4].
  • Moreover, the enzymatic dimerization of catechin monomers is reported for the first time suggesting a role for ANS beyond the oxidation of leucocyanidins [5].
  • This and other studies led to the proposal that ANS as well as FLS may select for dihydroflavonoid substrates carrying a "beta-face" C-3 hydroxyl group and initially form the 3-geminal diol by "alpha-face" hydroxylation [5].
  • The crystal structure of ANS reveals a multicomponent active site containing metal, cosubstrate, and two molecules of a substrate analog (dihydroquercetin) [6].

Anatomical context of LDOX


Associations of LDOX with chemical compounds


Analytical, diagnostic and therapeutic context of LDOX


  1. Mechanistic study on the oxidation of anthocyanidin synthase by quantum mechanical calculation. Nakajima, J., Sato, Y., Hoshino, T., Yamazaki, M., Saito, K. J. Biol. Chem. (2006) [Pubmed]
  2. AtMYB32 is required for normal pollen development in Arabidopsis thaliana. Preston, J., Wheeler, J., Heazlewood, J., Li, S.F., Parish, R.W. Plant J. (2004) [Pubmed]
  3. The Arabidopsis TDS4 gene encodes leucoanthocyanidin dioxygenase (LDOX) and is essential for proanthocyanidin synthesis and vacuole development. Abrahams, S., Lee, E., Walker, A.R., Tanner, G.J., Larkin, P.J., Ashton, A.R. Plant J. (2003) [Pubmed]
  4. Characterization of flavonol synthase and leucoanthocyanidin dioxygenase genes in Arabidopsis. Further evidence for differential regulation of "early" and "late" genes. Pelletier, M.K., Murrell, J.R., Shirley, B.W. Plant Physiol. (1997) [Pubmed]
  5. Anthocyanidin synthase from Gerbera hybrida catalyzes the conversion of (+)-catechin to cyanidin and a novel procyanidin. Wellmann, F., Griesser, M., Schwab, W., Martens, S., Eisenreich, W., Matern, U., Lukacin, R. FEBS Lett. (2006) [Pubmed]
  6. Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana. Wilmouth, R.C., Turnbull, J.J., Welford, R.W., Clifton, I.J., Prescott, A.G., Schofield, C.J. Structure (Camb.) (2002) [Pubmed]
  7. Mutation rate and novel tt mutants of Arabidopsis thaliana induced by carbon ions. Shikazono, N., Yokota, Y., Kitamura, S., Suzuki, C., Watanabe, H., Tano, S., Tanaka, A. Genetics (2003) [Pubmed]
  8. Purification, crystallization and preliminary X-ray diffraction of anthocyanidin synthase from Arabidopsis thaliana. Turnbull , J.J., Prescott , A.G., Schofield , C.J., Wilmouth , R.C. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
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