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Gene Review

LIG1  -  DNA ligase 1

Arabidopsis thaliana

Synonyms: ATLIG1, T6D22.23
 
 
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High impact information on ATLIG1

 

Biological context of ATLIG1

  • The level of the DNA ligase transcript was not increased in A. thaliana seedlings in response to DNA damage induced by a period of enhanced UV-B irradiation [4].
 

Analytical, diagnostic and therapeutic context of ATLIG1

  • Molecular cloning and functional analysis of the Arabidopsis thaliana DNA ligase I homologue [4].
  • A cDNA encoding the DNA ligase I homologue has been isolated from Arabidopsis thaliana using a degenerate PCR approach [4].
  • Chemically phosphorylated adjacent oligonucleotides of the gene to be synthesized are assembled and ligated on a single-stranded, partially homologous template derived from a wild-type gene (cryIC in our case) by a thermostable pfu DNA ligase using repeated cycles of melting, annealing, and ligation [6].

References

  1. Efficient gene tagging in Arabidopsis thaliana using a gene trap approach. Babiychuk, E., Fuangthong, M., Van Montagu, M., Inzé, D., Kushnir, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. An evolutionarily conserved translation initiation mechanism regulates nuclear or mitochondrial targeting of DNA ligase 1 in Arabidopsis thaliana. Sunderland, P.A., West, C.E., Waterworth, W.M., Bray, C.M. Plant J. (2006) [Pubmed]
  3. Arabidopsis DNA ligase IV is induced by gamma-irradiation and interacts with an Arabidopsis homologue of the double strand break repair protein XRCC4. West, C.E., Waterworth, W.M., Jiang, Q., Bray, C.M. Plant J. (2000) [Pubmed]
  4. Molecular cloning and functional analysis of the Arabidopsis thaliana DNA ligase I homologue. Taylor, R.M., Hamer, M.J., Rosamond, J., Bray, C.M. Plant J. (1998) [Pubmed]
  5. Choice of a start codon in a single transcript determines DNA ligase 1 isoform production and intracellular targeting in Arabidopsis thaliana. Sunderland, P.A., West, C.E., Waterworth, W.M., Bray, C.M. Biochem. Soc. Trans. (2004) [Pubmed]
  6. A synthetic cryIC gene, encoding a Bacillus thuringiensis delta-endotoxin, confers Spodoptera resistance in alfalfa and tobacco. Strizhov, N., Keller, M., Mathur, J., Koncz-Kálmán, Z., Bosch, D., Prudovsky, E., Schell, J., Sneh, B., Koncz, C., Zilberstein, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
 
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