The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DBNL  -  drebrin-like

Homo sapiens

Synonyms: ABP1, CMAP, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DBNL

  • We found that HIP-55 knockout mice were viable and fertile but showed decreased body weight and increased occurrence of death within the first 4 weeks after birth [1].
  • In these patients, muscle weakness, CMAP amplitudes and motor unit number estimates correlated with clinical disability, while motor NCV did not [2].
  • Lower monofilament detection and CMAP were independently associated with lower heel BUA (p < 0.01), and monofilament detection was associated with lower hip BMD (p < 0.05) in regression additionally adjusted for lifestyle factors, bone-active medications, and diabetes-related complications [3].
  • CONCLUSIONS: These findings imply that the expression level of CMAP in human cancer may be a new biomarker for both liver metastasis and the patient's outcome [4].
  • Thus, we studied the CMAP expression levels using a real-time quantitative reverse transcription-PCR for 79 patients with colorectal cancer, including 17 cases with liver metastasis [4].

High impact information on DBNL


Biological context of DBNL


Anatomical context of DBNL

  • HIP-55 binds to actin filaments both in vitro and in vivo [6].
  • Dissociation of the SH3 domain from the rest of the HIP-55 protein was observed in the NB4 APL cell line treated with arsenic trioxide due to specific cleavage by caspase 3-like enzymes [10].
  • SH3P7 migrates in sodium dodecyl sulfate-polyacrylamide gel electrophoresis as a 55-kDa protein that is preferentially expressed in brain, thymus, and spleen [5].
  • NCV and CMAP were assessed by surface electroneurography of the right peroneal nerve conducted in 1162 participants, 515 men and 647 women, age 21-96 years, free of major neurological diseases [11].
  • Electrophysiological studies revealed a sensory-motor neuropathy, predominantly axonal as evidenced by decreased CMAP amplitudes, with normal distal latencies-velocites, except for median nerve where a prolonged distal latency was observed [12].

Associations of DBNL with chemical compounds

  • The main-chain rmsd of the minimum-energy trp-cage conformation obtained for the GB/ACE/CHARMM22/CMAP landscape is less than 1 A. However, this energy function strongly favored helical structures for the two peptides shown by NMR to form beta-sheet structures [13].

Physical interactions of DBNL


Enzymatic interactions of DBNL


Other interactions of DBNL


Analytical, diagnostic and therapeutic context of DBNL

  • Lambert-Eaton myasthenic syndrome: A placebo-controlled crossover study reported a significant clinical improvement in the amplitude of the resting CMAP following IVIg treatment [15].
  • Distal compound muscle action potential (DCMAP) dispersion, defined as a DCMAP duration >/=9 ms, and proximal-distal (P-D) CMAP dispersion are considered useful in the electrodiagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) [16].
  • (3) Greater L-PMP-to-CMAP separation in the median than in the ulnar nerve was explained by cadaveric dissection, which revealed that the motor branch (responsible for the trailing CMAP) is longer in the median nerve than in the ulnar nerve relative to each nerve's corresponding digital sensory branch (responsible for the preceding L-PMP) [17].
  • The NI is derived from the CMAP, the DML and the F-wave frequency (CMAP amplitude/DML) x F frequency %), representing aspects of the effects of denervation and reinnervation, of degeneration of the terminal part of the motor axons, and of the excitability of anterior horn cells [18].


  1. HIP-55 is important for T-cell proliferation, cytokine production, and immune responses. Han, J., Shui, J.W., Zhang, X., Zheng, B., Han, S., Tan, T.H. Mol. Cell. Biol. (2005) [Pubmed]
  2. Neurological dysfunction and axonal degeneration in Charcot-Marie-Tooth disease type 1A. Krajewski, K.M., Lewis, R.A., Fuerst, D.R., Turansky, C., Hinderer, S.R., Garbern, J., Kamholz, J., Shy, M.E. Brain (2000) [Pubmed]
  3. Reduced Peripheral Nerve Function Is Related to Lower Hip BMD and Calcaneal QUS in Older White and Black Adults: The Health, Aging, and Body Composition Study. Strotmeyer, E.S., Cauley, J.A., Schwartz, A.V., de Rekeneire, N., Resnick, H.E., Zmuda, J.M., Shorr, R.I., Tylavsky, F.A., Vinik, A.I., Harris, T.B., Newman, A.B. J. Bone Miner. Res. (2006) [Pubmed]
  4. Cystatin-like metastasis-associated protein mRNA expression in human colorectal cancer is associated with both liver metastasis and patient survival. Utsunomiya, T., Hara, Y., Kataoka, A., Morita, M., Arakawa, H., Mori, M., Nishimura, S. Clin. Cancer Res. (2002) [Pubmed]
  5. SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors. Larbolette, O., Wollscheid, B., Schweikert, J., Nielsen, P.J., Wienands, J. Mol. Cell. Biol. (1999) [Pubmed]
  6. The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling. Han, J., Kori, R., Shui, J.W., Chen, Y.R., Yao, Z., Tan, T.H. J. Biol. Chem. (2003) [Pubmed]
  7. Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. Chen, Y.R., Kori, R., John, B., Tan, T.H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  8. Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. Le Bras, S., Foucault, I., Foussat, A., Brignone, C., Acuto, O., Deckert, M. J. Biol. Chem. (2004) [Pubmed]
  9. Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy. Meyer Zu Horste, G., Prukop, T., Liebetanz, D., Mobius, W., Nave, K.A., Sereda, M.W. Ann. Neurol. (2007) [Pubmed]
  10. PRAM-1 potentiates arsenic trioxide-induced JNK activation. Denis, F.M., Benecke, A., Di Gioia, Y., Touw, I.P., Cayre, Y.E., Lutz, P.G. J. Biol. Chem. (2005) [Pubmed]
  11. Axonal degeneration affects muscle density in older men and women. Lauretani, F., Bandinelli, S., Bartali, B., Iorio, A.D., Giacomini, V., Corsi, A.M., Guralnik, J.M., Ferrucci, L. Neurobiol. Aging (2006) [Pubmed]
  12. Reversible peripheral neuropathy in idiopathic hypoparathyroidism. Goswami, R., Bhatia, M., Goyal, R., Kochupillai, N. Acta neurologica Scandinavica. (2002) [Pubmed]
  13. Exploring peptide energy landscapes: a test of force fields and implicit solvent models. Steinbach, P.J. Proteins (2004) [Pubmed]
  14. A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1. Ensenat, D., Yao, Z., Wang, X.S., Kori, R., Zhou, G., Lee, S.C., Tan, T.H. J. Biol. Chem. (1999) [Pubmed]
  15. IVIg in myasthenia gravis, Lambert Eaton myasthenic syndrome and inflammatory myopathies: current status. Illa, I. J. Neurol. (2005) [Pubmed]
  16. Dispersion of compound muscle action potential in hereditary neuropathies and chronic inflammatory demyelinating polyneuropathy. Stanton, M., Pannoni, V., Lewis, R.A., Logigian, E.L., Naguib, D., Shy, M.E., Cleland, J., Herrmann, D.N. Muscle Nerve (2006) [Pubmed]
  17. Generator sources for the early and late ulnar hypothenar premotor potentials: short segment electrophysiologic studies and cadaveric dissection. Park, T.A., Jurell, K.C., Del Toro, D.R. Archives of physical medicine and rehabilitation. (1996) [Pubmed]
  18. The Neurophysiological Index in ALS. Swash, M., de Carvalho, M. Amyotroph. Lateral Scler. Other Motor Neuron Disord. (2004) [Pubmed]
WikiGenes - Universities