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Gene Review

Socs2  -  suppressor of cytokine signaling 2

Rattus norvegicus

Synonyms: Cish2, Cytokine-inducible SH2 protein 2, SOCS-2, Socs-2, Suppressor of cytokine signaling 2
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High impact information on Socs2

  • The expression of the suppressor of cytokine signaling-2 (SOCS-2) was increased twofold in GH-treated CRF animals, and SOCS-3 mRNA levels were elevated by 60% in CRF, independent of GH treatment [1].
  • Our findings suggest that SOCS2 regulates EGFR phosphorylation, leading to regulation of neurite outgrowth through a novel pathway that is distinct from GH [2].
  • SOCS2 binds to the GH receptor and inhibits GH signaling, including attenuation of STAT5 activation [2].
  • The overexpressed SOCS2 bound to the EGFR, which was constitutively phosphorylated at Tyr845, the Src binding site [2].
  • SOCS2 expression also resulted in a modest 30% decrease in phosphorylation of STAT5b at Tyr699, which is the primary site on STAT5 phosphorylated by GH; however, total tyrosine phosphorylation of STAT5 was decreased by 75-80% under basal and epidermal growth factor-stimulated conditions [2].

Biological context of Socs2


Anatomical context of Socs2


Other interactions of Socs2


  1. Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia. Schaefer, F., Chen, Y., Tsao, T., Nouri, P., Rabkin, R. J. Clin. Invest. (2001) [Pubmed]
  2. SOCS2 induces neurite outgrowth by regulation of epidermal growth factor receptor activation. Goldshmit, Y., Walters, C.E., Scott, H.J., Greenhalgh, C.J., Turnley, A.M. J. Biol. Chem. (2004) [Pubmed]
  3. Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines. Rosell, D.R., Akama, K.T., Nacher, J., McEwen, B.S. Neuroscience (2003) [Pubmed]
  4. Cis desensitizes GH induced Stat5 signaling in rat liver cells. Karlsson, H., Gustafsson, J.A., Mode, A. Mol. Cell. Endocrinol. (1999) [Pubmed]
  5. The effect of burn injury on suppressors of cytokine signalling. Ogle, C.K., Kong, F., Guo, X., Wells, D.A., Aosasa, S., Noel, G., Horseman, N. Shock (2000) [Pubmed]
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