Gene Review:
Socs2 - suppressor of cytokine signaling 2
Mus musculus
Synonyms:
8030460M17, AI527257, AW108012, CIS-2, CIS2, ...
Lorentzon,
Greenhalgh,
Mohan,
Alexander,
Ohlsson,
Davey,
McLachlan,
Wilkins,
Hilton,
Adams,
Michaylira,
Ramocki,
Simmons,
Tanner,
McNaughton,
Woosley,
Greenhalgh,
Lund,
Horvat,
Medrano,
Greenhalgh,
Rico-Bautista,
Lorentzon,
Thaus,
Morgan,
Willson,
Zervoudakis,
Metcalf,
Street,
Nicola,
Nash,
Fabri,
Norstedt,
Ohlsson,
Flores-Morales,
Alexander,
Hilton,
Haque,
Harbor,
Williams,
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells. Boverhof, D.R., Tam, E., Harney, A.S., Crawford, R.B., Kaminski, N.E., Zacharewski, T.R. Mol. Pharmacol. (2004)
- Suppressors of cytokine signalling and regulation of growth hormone action. Greenhalgh, C.J., Alexander, W.S. Growth Horm. IGF Res. (2004)
- Estrogen up-regulates hepatic expression of suppressors of cytokine signaling-2 and -3 in vivo and in vitro. Leong, G.M., Moverare, S., Brce, J., Doyle, N., Sjögren, K., Dahlman-Wright, K., Gustafsson, J.A., Ho, K.K., Ohlsson, C., Leung, K.C. Endocrinology (2004)
- Haplotype insufficiency for suppressor of cytokine signaling-2 enhances intestinal growth and promotes polyp formation in growth hormone-transgenic mice. Michaylira, C.Z., Ramocki, N.M., Simmons, J.G., Tanner, C.K., McNaughton, K.K., Woosley, J.T., Greenhalgh, C.J., Lund, P.K. Endocrinology (2006)
- Efficiency of growth in mice with a major gene for rapid postweaning gain. Calvert, C.C., Famula, T.R., Bernier, J.F., Khalaf, N., Bradford, G.E. J. Anim. Sci. (1986)
- Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling. Turnley, A.M., Faux, C.H., Rietze, R.L., Coonan, J.R., Bartlett, P.F. Nat. Neurosci. (2002)
- SOCS2 negatively regulates growth hormone action in vitro and in vivo. Greenhalgh, C.J., Rico-Bautista, E., Lorentzon, M., Thaus, A.L., Morgan, P.O., Willson, T.A., Zervoudakis, P., Metcalf, D., Street, I., Nicola, N.A., Nash, A.D., Fabri, L.J., Norstedt, G., Ohlsson, C., Flores-Morales, A., Alexander, W.S., Hilton, D.J. J. Clin. Invest. (2005)
- Knock your SOCS off! Leroith, D., Nissley, P. J. Clin. Invest. (2005)
- Lack of Socs2 expression causes the high-growth phenotype in mice. Horvat, S., Medrano, J.F. Genomics (2001)
- Identification of critical residues required for suppressor of cytokine signaling-specific regulation of interleukin-4 signaling. Haque, S.J., Harbor, P.C., Williams, B.R. J. Biol. Chem. (2000)
- Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. Egwuagu, C.E., Yu, C.R., Zhang, M., Mahdi, R.M., Kim, S.J., Gery, I. J. Immunol. (2002)
- STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver. Davey, H.W., McLachlan, M.J., Wilkins, R.J., Hilton, D.J., Adams, T.E. Mol. Cell. Endocrinol. (1999)
- SOCS-3 is an insulin-induced negative regulator of insulin signaling. Emanuelli, B., Peraldi, P., Filloux, C., Sawka-Verhelle, D., Hilton, D., Van Obberghen, E. J. Biol. Chem. (2000)
- PRL receptor-mediated effects in female mouse adipocytes: PRL induces suppressors of cytokine signaling expression and suppresses insulin-induced leptin production in adipocytes in vitro. Ling, C., Billig, H. Endocrinology (2001)
- Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects. Rico-Bautista, E., Greenhalgh, C.J., Tollet-Egnell, P., Hilton, D.J., Alexander, W.S., Norstedt, G., Flores-Morales, A. Mol. Endocrinol. (2005)
- Expression of "suppressor of cytokine signalling" (SOCS) genes in the developing and adult mouse nervous system. Polizzotto, M.N., Bartlett, P.F., Turnley, A.M. J. Comp. Neurol. (2000)
- Differential roles of SOCS family members in EpoR signal transduction. Jegalian, A.G., Wu, H. J. Interferon Cytokine Res. (2002)
- Reduced bone mineral density in SOCS-2-deficient mice. Lorentzon, M., Greenhalgh, C.J., Mohan, S., Alexander, W.S., Ohlsson, C. Pediatr. Res. (2005)