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Gene Review

PIK3R3  -  phosphoinositide-3-kinase, regulatory...

Homo sapiens

Synonyms: PI3-kinase regulatory subunit gamma, PI3-kinase subunit p55-gamma, PI3K regulatory subunit gamma, Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, Phosphatidylinositol 3-kinase regulatory subunit gamma, ...
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High impact information on PIK3R3


Biological context of PIK3R3


Anatomical context of PIK3R3

  • This mutant had a dominant-negative action on insulin-stimulated glucose transport, since insulin's effect on Glut 4 myc translocation was inhibited in adipocytes expressing mutant p55PIK [1].
  • Experiments presented here demonstrate that multiple forms of p55PIK detected in COS-7 cells were produced by alternative initiation of translation [3].

Associations of PIK3R3 with chemical compounds

  • Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation [3].

Other interactions of PIK3R3

  • Taken together, our results show that p55PIK interacts with key elements in the IGF-I signaling pathway, and that these interactions are negatively modulated by PI 3-kinase itself, providing circuitry for regulatory feedback control [1].

Analytical, diagnostic and therapeutic context of PIK3R3

  • Western blot analysis of p55PIK expression using a specific antibody against p55PIK revealed that multiple protein products with different molecular masses were detected in COS-7 cell extracts [3].


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