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ARFGAP1  -  ADP-ribosylation factor GTPase activating...

Homo sapiens

Synonyms: ADP-ribosylation factor 1 GTPase-activating protein, ADP-ribosylation factor GTPase-activating protein 1, ARF GAP 1, ARF1 GAP, ARF1-directed GTPase-activating protein, ...
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Psychiatry related information on ARFGAP1


High impact information on ARFGAP1


Biological context of ARFGAP1


Anatomical context of ARFGAP1


Physical interactions of ARFGAP1


Other interactions of ARFGAP1

  • The sorting scheme predicts a dependency on the amount of ARFGAP1 and explains the recent experimental findings that ARF-1 and COPI detach with different time constants from the Golgi membrane in vivo [11].
  • Assay and properties of the GIT1/p95-APP1 ARFGAP [12].
  • GIT1/p95-APP1 is an adaptor protein with an aminoterminal ARFGAP domain involved in the regulation of ARF6 function [12].
  • Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology [13].
  • An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells [2].

Analytical, diagnostic and therapeutic context of ARFGAP1

  • In order to initiate studies on the LHRH prohormone, three antisera (MC-1, MC-2 and MC-3) were generated using the human GAP (hGAP) 25-53 fragment as immunogen and a corresponding radioimmunoassay procedure was developed [14].


  1. Genotype-phenotype correlations to aid in the prognosis of individuals with uncommon 20q13.33 subtelomere deletions: a collaborative study on behalf of the 'association des Cytogénéticiens de langue Française'. Béri-Deixheimer, M., Gregoire, M.J., Toutain, A., Brochet, K., Briault, S., Schaff, J.L., Leheup, B., Jonveaux, P. Eur. J. Hum. Genet. (2007) [Pubmed]
  2. An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nishiya, N., Kiosses, W.B., Han, J., Ginsberg, M.H. Nat. Cell Biol. (2005) [Pubmed]
  3. A role for BARS at the fission step of COPI vesicle formation from Golgi membrane. Yang, J.S., Lee, S.Y., Spanò, S., Gad, H., Zhang, L., Nie, Z., Bonazzi, M., Corda, D., Luini, A., Hsu, V.W. EMBO J. (2005) [Pubmed]
  4. Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings. Hu, Y., Liu, Z., Ye, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. ADP-ribosylation factor 6 and a functional PIX/p95-APP1 complex are required for Rac1B-mediated neurite outgrowth. Albertinazzi, C., Za, L., Paris, S., de Curtis, I. Mol. Biol. Cell (2003) [Pubmed]
  6. Spatiotemporal dynamics of the COPI vesicle machinery. Elsner, M., Hashimoto, H., Simpson, J.C., Cassel, D., Nilsson, T., Weiss, M. EMBO Rep. (2003) [Pubmed]
  7. Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family. Zhang, C., Yu, Y., Zhang, S., Liu, M., Xing, G., Wei, H., Bi, J., Liu, X., Zhou, G., Dong, C., Hu, Z., Zhang, Y., Luo, L., Wu, C., Zhao, S., He, F. Genomics (2000) [Pubmed]
  8. Phosphoinositide-dependent activation of the ADP-ribosylation factor GTPase-activating protein ASAP1. Evidence for the pleckstrin homology domain functioning as an allosteric site. Kam, J.L., Miura, K., Jackson, T.R., Gruschus, J., Roller, P., Stauffer, S., Clark, J., Aneja, R., Randazzo, P.A. J. Biol. Chem. (2000) [Pubmed]
  9. AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton. Nie, Z., Stanley, K.T., Stauffer, S., Jacques, K.M., Hirsch, D.S., Takei, J., Randazzo, P.A. J. Biol. Chem. (2002) [Pubmed]
  10. Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein. Taylor, J.M., Heinrichs, D.E. Mol. Microbiol. (2002) [Pubmed]
  11. A kinetic proof-reading mechanism for protein sorting. Weiss, M., Nilsson, T. Traffic (2003) [Pubmed]
  12. Assay and properties of the GIT1/p95-APP1 ARFGAP. de Curtis, I., Paris, S. Meth. Enzymol. (2005) [Pubmed]
  13. Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology. Tanabe, K., Kon, S., Natsume, W., Torii, T., Watanabe, T., Satake, M. Cancer Sci. (2006) [Pubmed]
  14. Development of specific antisera and a radioimmunoassay procedure for the gonadotropin-releasing hormone associated peptide (GAP) of the LHRH prohormone. Culler, M.D., Negro-Vilar, A. Brain Res. Bull. (1986) [Pubmed]
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