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Gene Review

YOR1  -  ATP-binding cassette transporter YOR1

Saccharomyces cerevisiae S288c

Synonyms: Oligomycin resistance ATP-dependent permease YOR1, YGR281W
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Disease relevance of YOR1

  • Computer alignment indicates that Yor1p shows striking sequence similarity with multidrug resistance-associated protein, Saccharomyces cerevisiae Ycf1p, and the cystic fibrosis transmembrane conductance regulator [1].
  • A yor1 strain exhibits oligomycin hypersensitivity relative to an isogenic wild-type strain [1].

High impact information on YOR1


Biological context of YOR1


Anatomical context of YOR1

  • We have studied in detail three plasma membrane multidrug exporters: Pdr5p (TC3.A.1.205.1) and Snq2p (TC3.A.1.205.2) which share NBF-TM-NBF-TM topology as well as Yor1p (TC3.A.1.208.3) which exhibits the reciprocal TM-NBF-TM-NBF topology [4].

Associations of YOR1 with chemical compounds

  • We also demonstrated that Yor1p drives an energy-dependent, proton uncoupler-insensitive, cellular extrusion of rhodamine B [5].
  • The ATP binding cassette transporter-encoding genes regulated by Pdrlp include PDR5 and YOR1, which are required for normal cycloheximide and oligomycin tolerances, respectively [7].
  • In a clotrimazole-resistant mutant, CTZ21, isolated from the haploid sake yeast HL69, the levels of mRNA for three major ABC transporter genes, PDR5, SNQ2, and YOR1, markedly increased [8].
  • To explore the protein sequence requirements for Yor1p to move from the ER to its site of function at the plasma membrane, a series of truncation and alanine replacement mutations were constructed in Yor1p [9].
  • Pdr5p and two other yeast ATP-binding cassette transporters, Snq2p and Yor1p, were found to be phosphorylated on serine residues in vitro [10].

Physical interactions of YOR1

  • In the present study, we demonstrate that Yrr1p also mediates oligomycin resistance through activation of the ATP-binding cassette transporter-encoding gene YOR1 [11].

Enzymatic interactions of YOR1

  • Growth of yeast strains, either deleted for the vacuolar ABC transporter Ycf1 or deleted for the plasma membrane ABC transporter Yor1p or overexpressing Yor1p, were compared for their sensitivity to cadmium [12].

Other interactions of YOR1

  • Genetic studies showed that the aur3R mutant had a mutation in the PDR1 gene, which encodes a transcriptional regulator of PDR5 and YOR1 [13].
  • Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae [1].
  • Gene disruption experiments enable us to conclude that neither Bpt1p, Yor1p, Ybt1p nor YHL035p plays a major role in the detoxification of mercury [14].

Analytical, diagnostic and therapeutic context of YOR1


  1. Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Katzmann, D.J., Hallstrom, T.C., Voet, M., Wysock, W., Golin, J., Volckaert, G., Moye-Rowley, W.S. Mol. Cell. Biol. (1995) [Pubmed]
  2. Mutational disruption of plasma membrane trafficking of Saccharomyces cerevisiae Yor1p, a homologue of mammalian multidrug resistance protein. Katzmann, D.J., Epping, E.A., Moye-Rowley, W.S. Mol. Cell. Biol. (1999) [Pubmed]
  3. In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network. Kolaczkowski, M., Kolaczowska, A., Luczynski, J., Witek, S., Goffeau, A. Microb. Drug Resist. (1998) [Pubmed]
  4. The pleitropic drug ABC transporters from Saccharomyces cerevisiae. Rogers, B., Decottignies, A., Kolaczkowski, M., Carvajal, E., Balzi, E., Goffeau, A. J. Mol. Microbiol. Biotechnol. (2001) [Pubmed]
  5. ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. Decottignies, A., Grant, A.M., Nichols, J.W., de Wet, H., McIntosh, D.B., Goffeau, A. J. Biol. Chem. (1998) [Pubmed]
  6. Divergent transcriptional control of multidrug resistance genes in Saccharomyces cerevisiae. Hallstrom, T.C., Moye-Rowley, W.S. J. Biol. Chem. (1998) [Pubmed]
  7. Regulation of transcription factor Pdr1p function by an Hsp70 protein in Saccharomyces cerevisiae. Hallstrom, T.C., Katzmann, D.J., Torres, R.J., Sharp, W.J., Moye-Rowley, W.S. Mol. Cell. Biol. (1998) [Pubmed]
  8. Disruption of the ABC transporter genes PDR5, YOR1, and SNQ2, and their participation in improved fermentative activity of a sake yeast mutant showing pleiotropic drug resistance. Watanabe, M., Mizoguchi, H., Nishimura, A. J. Biosci. Bioeng. (2000) [Pubmed]
  9. Identification of interdependent signals required for anterograde traffic of the ATP-binding cassette transporter protein Yor1p. Epping, E.A., Moye-Rowley, W.S. J. Biol. Chem. (2002) [Pubmed]
  10. Casein kinase I-dependent phosphorylation and stability of the yeast multidrug transporter Pdr5p. Decottignies, A., Owsianik, G., Ghislain, M. J. Biol. Chem. (1999) [Pubmed]
  11. Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. Zhang, X., Cui, Z., Miyakawa, T., Moye-Rowley, W.S. J. Biol. Chem. (2001) [Pubmed]
  12. Role of the yeast ABC transporter Yor1p in cadmium detoxification. Nagy, Z., Montigny, C., Leverrier, P., Yeh, S., Goffeau, A., Garrigos, M., Falson, P. Biochimie (2006) [Pubmed]
  13. Role of ABC transporters in aureobasidin A resistance. Ogawa, A., Hashida-Okado, T., Endo, M., Yoshioka, H., Tsuruo, T., Takesako, K., Kato, I. Antimicrob. Agents Chemother. (1998) [Pubmed]
  14. Ycf1p-dependent Hg(II) detoxification in Saccharomyces cerevisiae. Gueldry, O., Lazard, M., Delort, F., Dauplais, M., Grigoras, I., Blanquet, S., Plateau, P. Eur. J. Biochem. (2003) [Pubmed]
  15. Analysis of gene network regulating yeast multidrug resistance by artificial activation of transcription factors: involvement of Pdr3 in salt tolerance. Onda, M., Ota, K., Chiba, T., Sakaki, Y., Ito, T. Gene (2004) [Pubmed]
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