The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

OLI1  -  F0 ATP synthase subunit c

Saccharomyces cerevisiae S288c

Synonyms: ATP synthase subunit 9, mitochondrial, ATP9, Lipid-binding protein, OLI3, Oligomycin resistance protein 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of OLI1


High impact information on OLI1

  • Assuming that the editing process in higher plant mitochondria reflects a requirement for producing active proteins, we have used edited and unedited coding sequences of wheat ATP synthase subunit 9 (atp9) fused to the coding sequence of a yeast coxIV transit peptide [1].
  • Transgenic plants containing unedited atp9 exhibited either fertile, semifertile, or male-sterile phenotypes; controls containing edited atp9 or only the selectable marker gave fertile plants [1].
  • The ATP binding cassette (ABC) transporter protein Yor1p was identified on the basis of its ability to elevate oligomycin resistance when it was overproduced from a high-copy-number plasmid [2].
  • However, PDR5 is not required for oligomycin resistance [3].
  • The presence of the oli1 leader sequence confers stability to the RNA and circumvents the CBP1 processing function [4].

Biological context of OLI1


Anatomical context of OLI1


Associations of OLI1 with chemical compounds

  • Recombination studies showed that the two mitochondrial mucidin loci were not allelic with other mitochondrial loci RIB1, RIB2 and OLI1 [12].
  • Importantly, transcript levels from the mitochondrial OLI1 gene, which has an associated organellar UAS, were attenuated in the DeltaYJR127C mutant during glycerol-based growth, but those from COX3 (OXI2), which lacks an associated mitochondrial UAS, were not [13].
  • We identified initiation sites for the 21 S and 14 S rRNAs; the phenylalanine, f-methionine, and glutamic tRNAs; two sites for the OLI-1 gene; and three for the ori (rep) regions [14].
  • Examples are multigene transcripts for the glutamic tRNA and COB genes and for the OLI-1, serine tRNA, and Var genes [14].
  • It is inferred that the suppressing mutation in the 5' untranslated region of oli1 mRNA restores subunit 9 biosynthesis by accommodating the modified structure of Aep2p generated by the aep2-ts1 mutation (shown here to cause the substitution of proline for leucine at residue 413 of Aep2p) [15].

Physical interactions of OLI1

  • In the present study, we demonstrate that Yrr1p also mediates oligomycin resistance through activation of the ATP-binding cassette transporter-encoding gene YOR1 [16].

Regulatory relationships of OLI1

  • Mutations in CBP1 can be suppressed by a p- genome in which the 5' untranslated leader of the oli1 gene (subunit 9 of the ATPase) is fused near the 5' side of the cytochrome b coding sequence [4].

Other interactions of OLI1

  • 3. Mutations in COB 1 have been found to be linked to the OLI1 locus in some but not in other strains of S. cervisiae [17].
  • Characterization of a second nuclear gene, AEP1, required for expression of the mitochondrial OLI1 gene in Saccharomyces cerevisiae [18].
  • The molecular weight of these fragments depends on the map position of the mutant, increasing in the direction OLI2 leads to OLI1 [19].
  • In vitro RNA footprint and deletion experiments have been used to define the p40-binding site on the leaders of COX1 and ATP9 mRNAs [20].
  • Mutations in the nuclear AEP2 gene of Saccharomyces generate greatly reduced levels of the mature form of mitochondrial oli1 mRNA, encoding subunit 9 of mitochondrial ATP synthase [15].

Analytical, diagnostic and therapeutic context of OLI1


  1. Male-sterility induction in transgenic tobacco plants with an unedited atp9 mitochondrial gene from wheat. Hernould, M., Suharsono, S., Litvak, S., Araya, A., Mouras, A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Mutational disruption of plasma membrane trafficking of Saccharomyces cerevisiae Yor1p, a homologue of mammalian multidrug resistance protein. Katzmann, D.J., Epping, E.A., Moye-Rowley, W.S. Mol. Cell. Biol. (1999) [Pubmed]
  3. Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Katzmann, D.J., Hallstrom, T.C., Voet, M., Wysock, W., Golin, J., Volckaert, G., Moye-Rowley, W.S. Mol. Cell. Biol. (1995) [Pubmed]
  4. Assembly of the mitochondrial membrane system. CBP1, a yeast nuclear gene involved in 5' end processing of cytochrome b pre-mRNA. Dieckmann, C.L., Koerner, T.J., Tzagoloff, A. J. Biol. Chem. (1984) [Pubmed]
  5. Spontaneous and photosensitiser-induced DNA single-strand breaks and formamidopyrimidine-DNA glycosylase sensitive sites at nucleotide resolutionin the nuclear and mitochondrial DNA of Saccharomyces cerevisiae. Meniel, V., Waters, R. Nucleic Acids Res. (1999) [Pubmed]
  6. Assembly of the mitochondrial membrane system: mutations in the pho2 locus of the mitochondrial genome of Saccharomyces cerevisiae. Coruzzi, G., Trembath, M.K., Tzagoloff, A. Eur. J. Biochem. (1978) [Pubmed]
  7. Genetics of oxidative phosphorylation: mitochondrial loci determining ossamycin-, venturicidin- and oligomycin-resistance in yeast. Lancashire, W.E., Mattoon, J.R. Mol. Gen. Genet. (1979) [Pubmed]
  8. Biogenesis of mitochondria: a mutation in the 5'-untranslated region of yeast mitochondrial oli1 mRNA leading to impairment in translation of subunit 9 of the mitochondrial ATPase complex. Ooi, B.G., Lukins, H.B., Linnane, A.W., Nagley, P. Nucleic Acids Res. (1987) [Pubmed]
  9. CBP1 function is required for stability of a hybrid cob-oli1 transcript in yeast mitochondria. Mittelmeier, T.M., Dieckmann, C.L. Curr. Genet. (1990) [Pubmed]
  10. Identification of interdependent signals required for anterograde traffic of the ATP-binding cassette transporter protein Yor1p. Epping, E.A., Moye-Rowley, W.S. J. Biol. Chem. (2002) [Pubmed]
  11. Protein and lipid motifs regulate phosphatidylserine traffic in yeast. Voelker, D.R. Biochem. Soc. Trans. (2005) [Pubmed]
  12. Mucidin resistance in yeast. Isolation, characterization and genetic analysis of nuclear and mitochondrial mucidin-resistant mutants of Saccharomyces cerevisiae. Subík, J., Kovácová, V., Takáscová, G. Eur. J. Biochem. (1977) [Pubmed]
  13. The YJR127C/ZMS1 gene product is involved in glycerol-based respiratory growth of the yeast Saccharomyces cerevisiae. Lu, L., Roberts, G.G., Oszust, C., Hudson, A.P. Curr. Genet. (2005) [Pubmed]
  14. Identification of multiple transcriptional initiation sites on the yeast mitochondrial genome by in vitro capping with guanylyltransferase. Christianson, T., Rabinowitz, M. J. Biol. Chem. (1983) [Pubmed]
  15. Suppression of a nuclear aep2 mutation in Saccharomyces cerevisiae by a base substitution in the 5'-untranslated region of the mitochondrial oli1 gene encoding subunit 9 of ATP synthase. Ellis, T.P., Lukins, H.B., Nagley, P., Corner, B.E. Genetics (1999) [Pubmed]
  16. Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. Zhang, X., Cui, Z., Miyakawa, T., Moye-Rowley, W.S. J. Biol. Chem. (2001) [Pubmed]
  17. Assembly of the mitochondrial membrane system. XVIII. Genetic loci on mitochondrial DNA involved in cytochrome b biosynthesis. Tzagoloff, A., Foury, F., Akai, A. Mol. Gen. Genet. (1976) [Pubmed]
  18. Characterization of a second nuclear gene, AEP1, required for expression of the mitochondrial OLI1 gene in Saccharomyces cerevisiae. Payne, M.J., Finnegan, P.M., Smooker, P.M., Lukins, H.B. Curr. Genet. (1993) [Pubmed]
  19. The mitochondrial COB region in yeast codes for apocytochrome b and is mosaic. Haid, A., Schweyen, R.J., Bechmann, H., Kaudewitz, F., Solioz, M., Schatz, G. Eur. J. Biochem. (1979) [Pubmed]
  20. Determinants for binding of a 40 kDa protein to the leaders of yeast mitochondrial mRNAs. Dekker, P.J., Stuurman, J., van Oosterum, K., Grivell, L.A. Nucleic Acids Res. (1992) [Pubmed]
  21. Amino acid substitutions in subunit 9 of the mitochondrial ATPase complex of Saccharomyces cerevisiae. Sequence analysis of a series of revertants of an oli1 mit- mutant carrying an amino acid substitution in the hydrophilic loop of subunit 9. Willson, T.A., Nagley, P. Eur. J. Biochem. (1987) [Pubmed]
WikiGenes - Universities