Gene Review:
YDJ1 - type I HSP40 co-chaperone YDJ1
Saccharomyces cerevisiae S288c
Synonyms:
HSP40, MAB3, MAS5, Mitochondrial protein import protein MAS5, N2418, ...
- A conserved HPD sequence of the J-domain is necessary for YDJ1 stimulation of Hsp70 ATPase activity at a site distinct from substrate binding. Tsai, J., Douglas, M.G. J. Biol. Chem. (1996)
- The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj1. Fan, C.Y., Ren, H.Y., Lee, P., Caplan, A.J., Cyr, D.M. J. Biol. Chem. (2005)
- CDC37 is required for p60v-src activity in yeast. Dey, B., Lightbody, J.J., Boschelli, F. Mol. Biol. Cell (1996)
- YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism. Caplan, A.J., Cyr, D.M., Douglas, M.G. Cell (1992)
- Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways. Kimura, Y., Yahara, I., Lindquist, S. Science (1995)
- Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein. Caplan, A.J., Douglas, M.G. J. Cell Biol. (1991)
- Loss of Hsp70-Hsp40 chaperone activity causes abnormal nuclear distribution and aberrant microtubule formation in M-phase of Saccharomyces cerevisiae. Oka, M., Nakai, M., Endo, T., Lim, C.R., Kimata, Y., Kohno, K. J. Biol. Chem. (1998)
- Mutations in the yeast Hsp40 chaperone protein Ydj1 cause defects in Axl1 biogenesis and pro-a-factor processing. Meacham, G.C., Browne, B.L., Zhang, W., Kellermayer, R., Bedwell, D.M., Cyr, D.M. J. Biol. Chem. (1999)
- The glycine-phenylalanine-rich region determines the specificity of the yeast Hsp40 Sis1. Yan, W., Craig, E.A. Mol. Cell. Biol. (1999)
- A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s. Schlenstedt, G., Harris, S., Risse, B., Lill, R., Silver, P.A. J. Cell Biol. (1995)
- The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Yaglom, J.A., Goldberg, A.L., Finley, D., Sherman, M.Y. Mol. Cell. Biol. (1996)
- Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p. Kabani, M., Beckerich, J.M., Brodsky, J.L. Mol. Cell. Biol. (2002)
- A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeast. Johnson, J.L., Craig, E.A. Mol. Cell. Biol. (2000)
- Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae. Caplan, A.J., Tsai, J., Casey, P.J., Douglas, M.G. J. Biol. Chem. (1992)
- Molecular chaperones and the assembly of the prion Sup35p, an in vitro study. Krzewska, J., Melki, R. EMBO J. (2006)
- The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme. Hon, T., Lee, H.C., Hach, A., Johnson, J.L., Craig, E.A., Erdjument-Bromage, H., Tempst, P., Zhang, L. Mol. Cell. Biol. (2001)
- Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER. McClellan, A.J., Endres, J.B., Vogel, J.P., Palazzi, D., Rose, M.D., Brodsky, J.L. Mol. Biol. Cell (1998)
- Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. Lian, H.Y., Zhang, H., Zhang, Z.R., Loovers, H.M., Jones, G.W., Rowling, P.J., Itzhaki, L.S., Zhou, J.M., Perrett, S. J. Biol. Chem. (2007)
- Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo. Becker, J., Walter, W., Yan, W., Craig, E.A. Mol. Cell. Biol. (1996)
- A yeast heat shock transcription factor (Hsf1) mutant is defective in both Hsc82/Hsp82 synthesis and spindle pole body duplication. Zarzov, P., Boucherie, H., Mann, C. J. Cell. Sci. (1997)
- Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein. Izawa, I., Nishizawa, M., Ohtakara, K., Ohtsuka, K., Inada, H., Inagaki, M. J. Biol. Chem. (2000)
- Purification, crystallization and preliminary X-ray crystallographic studies of S. cerevisiae Hsp40 Sis1. Sha, B., Cyr, D. Acta Crystallogr. D Biol. Crystallogr. (1999)