The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

YHC3  -  Yhc3p

Saccharomyces cerevisiae S288c

Synonyms: BTN1, J1139, Protein BTN1, YJL059W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of YHC3


High impact information on YHC3

  • Furthermore, DNA microarray analysis of BTN1 and btn1-delta strains revealed differential expression of two genes, with at least one, HSP30, involved in pH control [2].
  • Because Btn1p is located in the vacuole, we suggest that Batten disease is caused by a defect in vacuolar (lysosomal) pH control [2].
  • Here, we report that btn1-delta yeast strains have an abnormally acidic vacuolar pH in the early phases of growth [2].
  • Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease [3].
  • Furthermore, the severity of Batten disease in humans and the degree of ANP resistance in yeast are related when the equivalent amino acid replacements in Cln3p and Btn1p are compared [4].

Biological context of YHC3


Anatomical context of YHC3

  • These data indicate that BTN1 is a nonessential gene under most growth conditions which functions in the vacuole in yeast Saccharomyces cerevisiae [5].
  • Furthermore, btn1-Delta strains have an elevated activity of the plasma membrane H(+)-ATPase due to an abnormally high vacuolar acidity during the early phase of growth [1].
  • A previous study on the yeast homolog to CLN3, designated Btn1p, revealed a potential role for CLN3 in the transport of arginine into the yeast vacuole, the equivalent organelle to the mammalian lysosome [8].

Associations of YHC3 with chemical compounds

  • We previously reported that Btn1p is required for vacuolar pH maintenance and ATP-dependent vacuolar arginine transport [6].
  • Deletion of BTN1, BTN2, or HSP30 does not alter cytosolic pH but diminishes pH buffering capacity and causes poor growth at low pH in a medium containing sorbic acid, a condition known to result in disturbed intracellular pH homeostasis [1].

Other interactions of YHC3


  1. The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis. Chattopadhyay, S., Muzaffar, N.E., Sherman, F., Pearce, D.A. J. Bacteriol. (2000) [Pubmed]
  2. Action of BTN1, the yeast orthologue of the gene mutated in Batten disease. Pearce, D.A., Ferea, T., Nosel, S.A., Das, B., Sherman, F. Nat. Genet. (1999) [Pubmed]
  3. Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease. Pearce, D.A., Carr, C.J., Das, B., Sherman, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. A yeast model for the study of Batten disease. Pearce, D.A., Sherman, F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. The subcellular location of the yeast Saccharomyces cerevisiae homologue of the protein defective in the juvenile form of Batten disease. Croopnick, J.B., Choi, H.C., Mueller, D.M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  6. Saccharomyces cerevisiae lacking Btn1p modulate vacuolar ATPase activity to regulate pH imbalance in the vacuole. Padilla-López, S., Pearce, D.A. J. Biol. Chem. (2006) [Pubmed]
  7. Btn2, a hook1 ortholog and potential batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast. Kama, R., Robinson, M., Gerst, J.E. Mol. Cell. Biol. (2007) [Pubmed]
  8. Defective lysosomal arginine transport in juvenile Batten disease. Ramirez-Montealegre, D., Pearce, D.A. Hum. Mol. Genet. (2005) [Pubmed]
  9. Studies of pH regulation by Btn1p, the yeast homolog of human Cln3p. Pearce, D.A., Nosel, S.A., Sherman, F. Mol. Genet. Metab. (1999) [Pubmed]
  10. Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the vacuole, amino acid levels, and ion homeostasis in the yeast Saccharomyces cerevisiae. Kim, Y., Chattopadhyay, S., Locke, S., Pearce, D.A. Eukaryotic Cell (2005) [Pubmed]
WikiGenes - Universities