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Gene Review

BTN2  -  Btn2p

Saccharomyces cerevisiae S288c

Synonyms: Batten disease protein 2, Protein BTN2, YGR142W
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High impact information on BTN2


Biological context of BTN2


Anatomical context of BTN2


Associations of BTN2 with chemical compounds

  • Deletion of BTN1, BTN2, or HSP30 does not alter cytosolic pH but diminishes pH buffering capacity and causes poor growth at low pH in a medium containing sorbic acid, a condition known to result in disturbed intracellular pH homeostasis [3].
  • Overexpression of BTN2 results in a decreased rate of arginine uptake [4].
  • We now report that Btn2p interacts biochemically and functionally with Rsglp, a down-regulator of the Can1p arginine and lysine permease [4].
  • Rsglp localizes to a distinct structure toward the cell periphery, and strains lacking Btn2p (btn2delta strains) fail to correctly localize Rsg1p. btn2delta strains, like rsg1delta strains, are sensitive for growth in the presence of the arginine analog canavanine [4].
  • Btn2p, a novel coiled-coil protein, is up-regulated in btn1delta yeast strains, and this up-regulation is thought to contribute to maintaining a stable vacuolar pH in btn1delta strains (D. A. Pearce, T. Ferea, S. A. Nosel, B. Das, and F. Sherman, Nat. Genet. 22:55-58, 1999) [4].

Other interactions of BTN2


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