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Gene Review

SFC1  -  Sfc1p

Saccharomyces cerevisiae S288c

Synonyms: ACR1, J1921, Regulator of acetyl-CoA synthase activity, Succinate/fumarate mitochondrial transporter, YJR095W
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Disease relevance of SFC1


High impact information on SFC1

  • Complementation of a yeast acr1 mutant carrying a deletion of the succinate/fumarate carrier gene enabled functional identification of a mitochondrial succinate translocator from Arabidopsis thaliana (AtmSFC1) [2].
  • Protein binding to carbon source response elements of the ICL1 promoter was competed by all three elements to various extents by the respective ACR1 sequences [3].
  • The ACR1 gene, encoding a succinate-fumarate transporter, is required by the yeast Saccharomyces cerevisiae for ethanol utilization [3].
  • In addition, two putative stress response promoter elements present in the ACR1 promoter were investigated in deletion analyses and shown to contribute to gene expression [3].
  • The protein encoded by the ACR1 gene in Saccharomyces cerevisiae belongs to a family of 35 related membrane proteins that are encoded in the fungal genome [1].

Biological context of SFC1

  • Our results, in conjunction with previous biochemical data, clearly identify Acr1p as an element which is directly involved in gluconeogenesis, functioning as the mitochondrial carrier which links the anaplerotic reactions of the glyoxylate cycle to the TCA cycle [4].

Associations of SFC1 with chemical compounds

  • The product of the ACR1 gene is essential for growth of Saccharomyces cerevisiae on ethanol or acetate as sole carbon source, and its expression is subject to glucose repression [4].
  • It was previously shown that Acr1p is a membrane protein which specifically transports succinate and fumarate [4].
  • ACR1, a gene encoding a protein related to mitochondrial carriers, is essential for acetyl-CoA synthetase activity in Saccharomyces cerevisiae [5].

Regulatory relationships of SFC1


Other interactions of SFC1

  • We demonstrate that derepression of ACR1 is strictly dependent on the Zn2Cys6-type transcriptional activator Cat8p [4].

Analytical, diagnostic and therapeutic context of SFC1

  • Immunoprecipitation of Sfc3p further revealed that Sfc1p, Sfc3p, Sfc4p, and Sfc6p are associated in vivo and that the isolated Sfc3p complex is active for pol III-mediated transcription of a S. pombe tRNA gene in vitro [6].


  1. Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate. Palmieri, L., Lasorsa, F.M., De Palma, A., Palmieri, F., Runswick, M.J., Walker, J.E. FEBS Lett. (1997) [Pubmed]
  2. Identification of an Arabidopsis mitochondrial succinate-fumarate translocator. Catoni, E., Schwab, R., Hilpert, M., Desimone, M., Schwacke, R., Flügge, U.I., Schumacher, K., Frommer, W.B. FEBS Lett. (2003) [Pubmed]
  3. Multiple regulatory elements control the expression of the yeast ACR1 gene. Redruello, B., Valdes, E., Luz Lopez, M., Rodicio, R. FEBS Lett. (1999) [Pubmed]
  4. The succinate/fumarate transporter Acr1p of Saccharomyces cerevisiae is part of the gluconeogenic pathway and its expression is regulated by Cat8p. Bojunga, N., Kötter, P., Entian, K.D. Mol. Gen. Genet. (1998) [Pubmed]
  5. ACR1, a gene encoding a protein related to mitochondrial carriers, is essential for acetyl-CoA synthetase activity in Saccharomyces cerevisiae. Fernández, M., Fernández, E., Rodicio, R. Mol. Gen. Genet. (1994) [Pubmed]
  6. Isolation and cloning of four subunits of a fission yeast TFIIIC complex that includes an ortholog of the human regulatory protein TFIIICbeta. Huang, Y., Hamada, M., Maraia, R.J. J. Biol. Chem. (2000) [Pubmed]
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