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Gene Review

CAT8  -  Cat8p

Saccharomyces cerevisiae S288c

Synonyms: DIL1, MSP8, Regulatory protein CAT8, YM8021.06C, YMR280C
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High impact information on CAT8

  • Glucose derepression of gluconeogenesis depends on the active Cat1 (Snf1) protein kinase and the Cat8 zinc cluster activator [1].
  • Our analysis also uncovered promoters that Adr1 binds but does not regulate and promoters that are indirectly regulated by Cat8, stressing the advantage of combining global expression and global localization analysis to find directly regulated targets [2].
  • The Snf1-Cat8 connection is evolutionarily conserved: mutation of corresponding serine 562 of ScCat8p gave similar results in S. cerevisiae [3].
  • This finding suggests an upstream activating function of this promoter region, which is Mig1p independent, as delta mig1 mutants are still able to derepress the CAT8 promoter [4].
  • No other putative binding sites such as a Hap2/3/4/5p site and an Abf1p consensus site were functional with respect to glucose-regulated CAT8 expression [4].

Biological context of CAT8


Associations of CAT8 with chemical compounds


Physical interactions of CAT8

  • In conclusion, these results show a derepression of ADH2 by synergistically acting regulators Adr1 (interacting with UAS1) and Cat8, binding to UAS2 (=CSRE(ADH2)) [12].

Regulatory relationships of CAT8

  • Expression of CAT8 is carbon source regulated and requires a functional Cat1p (Snf1p) protein kinase [5].

Other interactions of CAT8

  • A CAT8-lacZ promoter fusion revealed that the CAT8 gene itself is repressed by Cat4p (Mig1p) [7].
  • The CAT8 gene encodes a zinc cluster protein related to Saccharomyces cerevisiae Gal4p [7].
  • Derepression of CAT8 also requires a functional HAP2 gene, suggesting a regulatory connection between respiratory and gluconeogenic genes [5].
  • We have isolated a regulatory gene, DIL1 (derepression of isocitrate lyase, = CAT8), which is specifically required for derepression of CSRE-dependent genes [5].
  • Only a small number of ADR1-dependent genes are also CAT8-dependent [8].

Analytical, diagnostic and therapeutic context of CAT8


  1. CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae. Proft, M., Kötter, P., Hedges, D., Bojunga, N., Entian, K.D. EMBO J. (1995) [Pubmed]
  2. Combined global localization analysis and transcriptome data identify genes that are directly coregulated by Adr1 and Cat8. Tachibana, C., Yoo, J.Y., Tagne, J.B., Kacherovsky, N., Lee, T.I., Young, E.T. Mol. Cell. Biol. (2005) [Pubmed]
  3. Key role of Ser562/661 in Snf1-dependent regulation of Cat8p in Saccharomyces cerevisiae and Kluyveromyces lactis. Charbon, G., Breunig, K.D., Wattiez, R., Vandenhaute, J., Noël-Georis, I. Mol. Cell. Biol. (2004) [Pubmed]
  4. Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p. Randez-Gil, F., Bojunga, N., Proft, M., Entian, K.D. Mol. Cell. Biol. (1997) [Pubmed]
  5. Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8. Rahner, A., Schöler, A., Martens, E., Gollwitzer, B., Schüller, H.J. Nucleic Acids Res. (1996) [Pubmed]
  6. Derepression of gene expression mediated by the 5' upstream region of the isocitrate lyase gene of Candida tropicalis is controlled by two distinct regulatory pathways in Saccharomyces cerevisiae. Umemura, K., Atomi, H., Kanai, T., Takeshita, S., Kanayama, N., Ueda, M., Tanaka, A. Eur. J. Biochem. (1997) [Pubmed]
  7. CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae. Hedges, D., Proft, M., Entian, K.D. Mol. Cell. Biol. (1995) [Pubmed]
  8. Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. Young, E.T., Dombek, K.M., Tachibana, C., Ideker, T. J. Biol. Chem. (2003) [Pubmed]
  9. The transcriptional activator Cat8p provides a major contribution to the reprogramming of carbon metabolism during the diauxic shift in Saccharomyces cerevisiae. Haurie, V., Perrot, M., Mini, T., Jenö, P., Sagliocco, F., Boucherie, H. J. Biol. Chem. (2001) [Pubmed]
  10. Three target genes for the transcriptional activator Cat8p of Kluyveromyces lactis: acetyl coenzyme A synthetase genes KlACS1 and KlACS2 and lactate permease gene KlJEN1. Lodi, T., Saliola, M., Donnini, C., Goffrini, P. J. Bacteriol. (2001) [Pubmed]
  11. The succinate/fumarate transporter Acr1p of Saccharomyces cerevisiae is part of the gluconeogenic pathway and its expression is regulated by Cat8p. Bojunga, N., Kötter, P., Entian, K.D. Mol. Gen. Genet. (1998) [Pubmed]
  12. Adr1 and Cat8 synergistically activate the glucose-regulated alcohol dehydrogenase gene ADH2 of the yeast Saccharomyces cerevisiae. Walther, K., Schüller, H.J. Microbiology (Reading, Engl.) (2001) [Pubmed]
  13. Contribution of Cat8 and Sip4 to the transcriptional activation of yeast gluconeogenic genes by carbon source-responsive elements. Hiesinger, M., Roth, S., Meissner, E., Schüller, H.J. Curr. Genet. (2001) [Pubmed]
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