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Gene Review

CTF13  -  Ctf13p

Saccharomyces cerevisiae S288c

Synonyms: CBF3C, Centromere DNA-binding protein complex CBF3 subunit C, Chromosome transmission fidelity protein 13, Kinetochore protein CTF13, YM6543.01, ...
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High impact information on CTF13

  • Together, the genetic and biochemical data indicate that CTF13 is an essential kinetochore protein [1].
  • CTF13 is an essential gene that encodes a predicted 478 amino acid protein with no homology to known proteins. ctf13 mutants missegregate chromosomes at permissive temperature and transiently arrest at nonpermissive temperature as large-budded cells with a G2 DNA content and a short spindle [1].
  • Finally, data are provided to show that Cbf3c is encoded by CTF13, a gene that had been cloned recently by complementing a temperature sensitive mutant that exhibits chromosome loss as a result of a defective centromere [2].
  • Here, we investigate how the Ctf13p/Skp1p complex becomes competent to form the CBF3-centromere DNA complex [3].
  • Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore [3].

Biological context of CTF13


Associations of CTF13 with chemical compounds


Other interactions of CTF13

  • Most importantly, loss of UPF1 function causes increased accumulation of wild-type CTF13 mRNA but has no effect on the mRNA half-life [8].
  • As revealed by mass spectrometry, Ctf13p and Skp1p carry two and four phosphate groups, respectively [3].
  • We determined that Ndc10p, Ctf13p, and Cep3p are required for checkpoint activity [9].


  1. Identification of essential components of the S. cerevisiae kinetochore. Doheny, K.F., Sorger, P.K., Hyman, A.A., Tugendreich, S., Spencer, F., Hieter, P. Cell (1993) [Pubmed]
  2. A zinc finger protein, essential for chromosome segregation, constitutes a putative DNA binding subunit of the Saccharomyces cerevisiae kinetochore complex, Cbf3. Lechner, J. EMBO J. (1994) [Pubmed]
  3. Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore. Stemmann, O., Neidig, A., Köcher, T., Wilm, M., Lechner, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Establishing genetic interactions by a synthetic dosage lethality phenotype. Kroll, E.S., Hyland, K.M., Hieter, P., Li, J.J. Genetics (1996) [Pubmed]
  5. The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion. Baetz, K.K., Krogan, N.J., Emili, A., Greenblatt, J., Hieter, P. Mol. Cell. Biol. (2004) [Pubmed]
  6. Identification of cut8+ and cek1+, a novel protein kinase gene, which complement a fission yeast mutation that blocks anaphase. Samejima, I., Yanagida, M. Mol. Cell. Biol. (1994) [Pubmed]
  7. Isolation and partial characterization of the Kluyveromyces lactis homologue of SKP1. Winkler, A.A., Goedegebure, R.H., Zonneveld, B.J., Steensma, H.Y., Hooykaas, P.J. Curr. Genet. (2000) [Pubmed]
  8. Accumulation of mRNA coding for the ctf13p kinetochore subunit of Saccharomyces cerevisiae depends on the same factors that promote rapid decay of nonsense mRNAs. Dahlseid, J.N., Puziss, J., Shirley, R.L., Atkin, A.L., Hieter, P., Culbertson, M.R. Genetics (1998) [Pubmed]
  9. The spindle checkpoint of the yeast Saccharomyces cerevisiae requires kinetochore function and maps to the CBF3 domain. Gardner, R.D., Poddar, A., Yellman, C., Tavormina, P.A., Monteagudo, M.C., Burke, D.J. Genetics (2001) [Pubmed]
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