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Gene Review

HEM14  -  oxygen-dependent protoporphyrinogen oxidase

Saccharomyces cerevisiae S288c

Synonyms: PPO, Protoporphyrinogen oxidase, YER014W
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Disease relevance of HEM14


High impact information on HEM14


Biological context of HEM14


Anatomical context of HEM14


Associations of HEM14 with chemical compounds


Analytical, diagnostic and therapeutic context of HEM14


  1. Cloning and characterization of the yeast HEM14 gene coding for protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides. Camadro, J.M., Labbe, P. J. Biol. Chem. (1996) [Pubmed]
  2. Protoporphyrinogen oxidase as a molecular target for diphenyl ether herbicides. Matringe, M., Camadro, J.M., Labbe, P., Scalla, R. Biochem. J. (1989) [Pubmed]
  3. Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides. Arnould, S., Takahashi, M., Camadro, J.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. The domain structure of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides. Arnould, S., Camadro, J.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Purification and properties of protoporphyrinogen oxidase from the yeast Saccharomyces cerevisiae. Mitochondrial location and evidence for a precursor form of the protein. Camadro, J.M., Thome, F., Brouillet, N., Labbe, P. J. Biol. Chem. (1994) [Pubmed]
  6. Cloning and identification of HEM14, the yeast gene for mitochondrial protoporphyrinogen oxidase. Glerum, D.M., Shtanko, A., Tzagoloff, A., Gorman, N., Sinclair, P.R. Yeast (1996) [Pubmed]
  7. Kinetics of protoporphyrinogen oxidase inhibition by diphenyleneiodonium derivatives. Arnould, S., Berthon, J.L., Hubert, C., Dias, M., Cibert, C., Mornet, R., Camadro, J.M. Biochemistry (1997) [Pubmed]
  8. Inhibition of protoporphyrinogen oxidase expression in Arabidopsis causes a lesion-mimic phenotype that induces systemic acquired resistance. Molina, A., Volrath, S., Guyer, D., Maleck, K., Ryals, J., Ward, E. Plant J. (1999) [Pubmed]
  9. Photoaffinity labeling of protoporphyrinogen oxidase, the molecular target of diphenylether-type herbicides. Camadro, J.M., Matringe, M., Thome, F., Brouillet, N., Mornet, R., Labbe, P. Eur. J. Biochem. (1995) [Pubmed]
  10. The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX. Protoporphyrinogen oxidase activity in mitochondrial extracts of Saccharomyces cerevisiae. Poulson, R., Polglase, W.J. J. Biol. Chem. (1975) [Pubmed]
  11. Protoporphyrinogen oxidase inhibition by three peroxidizing herbicides: oxadiazon, LS 82-556 and M&B 39279. Matringe, M., Camadro, J.M., Labbe, P., Scalla, R. FEBS Lett. (1989) [Pubmed]
  12. Rat liver protoporphyrinogen IX oxidase: site of synthesis and factor influencing its activity. Kolarov, J., Nelson, B.D., Kuzela, S. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  13. The regulation of heme biosynthesis. Poulson, R. Ann. Clin. Res. (1976) [Pubmed]
  14. Stability of recombinant yeast protoporphyrinogen oxidase: effects of diphenyl ether-type herbicides and diphenyleneiodonium. Arnould, S., Takahashi, M., Camadro, J.M. Biochemistry (1998) [Pubmed]
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