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Chemical Compound Review

Blazer     5-[2-chloro-4- (trifluoromethyl)phenoxy]- 2...

Synonyms: Acifluorfen, Acifluorfene, Acifluorofen, PPG-847, SureCN38929, ...
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Disease relevance of Tackle

  • Extracts of E. coli cells transformed with the Arabidopsis PPOX cDNA had high PPOX activity, and this activity was markedly inhibited by acifluorfen, a specific inhibitor of PPOX [1].
  • Effects of UVBR on three selected pesticides (Atrazine, carbaryl and Acifluorfen) and possible induction of phototoxicity are reviewed [2].
  • The interaction of the herbicides acifluorfen and paraquat with the photosynthetic reaction center from Rhodobacter sphaeroides has been studied by NMR relaxation measurements [3].
  • In the present study we show that long term maintenance of murine erythroleukemia (MEL) cells in acifluorfen, which is normally toxic to these cells at 5 microM concentration, results in cells that grow at a near normal rate in 100 microM acifluorfen [4].
  • Toxicity tests against Daphnia magna Strauss showed that acifluorfen was not toxic at a concentration of 0.1 mM; however, photoproducts formed after 36 h of UV exposure of the herbicide induced a remarkable toxicity to the test organism [5].

High impact information on Tackle


Biological context of Tackle


Anatomical context of Tackle


Associations of Tackle with other chemical compounds

  • The photolytic degradations of asulam, triclopyr, acifluorfen, and atrazine were independently compared in air-dried soils and in moist (75% field moisture capacity at 0.33 bar) soils maintained at initial conditions through the use of a specially designed soil photolysis apparatus [16].
  • Diphenyl ether (DPE) herbicides such as acifluorfen inhibit both the plant and mammalian forms of protoporphyrinogen oxidase, a heme biosynthetic enzyme [17].

Gene context of Tackle


Analytical, diagnostic and therapeutic context of Tackle


  1. Molecular cloning and characterization of a cDNA that encodes protoporphyrinogen oxidase of Arabidopsis thaliana. Narita, S., Tanaka, R., Ito, T., Okada, K., Taketani, S., Inokuchi, H. Gene (1996) [Pubmed]
  2. Ecotoxicological Effects of Combined UVB and Organic Contaminants in Coastal Waters: A Review. Pelletier, E., Sargian, P., Payet, J., Demers, S. Photochem. Photobiol. (2006) [Pubmed]
  3. NMR structural model of the interaction of herbicides with the photosynthetic reaction center from Rhodobacter sphaeroides. D'Amelio, N., Gaggelli, E., Mlynarz, P., Molteni, E., Valensin, G., Lubitz, W. Chembiochem (2004) [Pubmed]
  4. Generation of resistance to the diphenyl ether herbicide acifluorfen by MEL cells. Prasad, A.R., Dailey, H.A. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  5. Photochemistry and photoinduced toxicity of acifluorfen, a diphenyl-ether herbicide. Scrano, L., Bufo, S.A., D'Auria, M., Meallier, P., Behechti, A., Shramm, K.W. J. Environ. Qual. (2002) [Pubmed]
  6. Cloning of a human cDNA for protoporphyrinogen oxidase by complementation in vivo of a hemG mutant of Escherichia coli. Nishimura, K., Taketani, S., Inokuchi, H. J. Biol. Chem. (1995) [Pubmed]
  7. Esa1, an Arabidopsis mutant with enhanced susceptibility to a range of necrotrophic fungal pathogens, shows a distorted induction of defense responses by reactive oxygen generating compounds. Tierens, K.F., Thomma, B.P., Bari, R.P., Garmier, M., Eggermont, K., Brouwer, M., Penninckx, I.A., Broekaert, W.F., Cammue, B.P. Plant J. (2002) [Pubmed]
  8. Ecotoxicological effects of combined UVB and organic contaminants in coastal waters: a review. Pelletier, E., Sargian, P., Payet, J., Demers, S. Photochem. Photobiol. (2006) [Pubmed]
  9. Homoglutathione confers tolerance to acifluorfen in transgenic tobacco plants expressing soybean homoglutathione synthetase. Sugiyama, A., Sekiya, J. Plant Cell Physiol. (2005) [Pubmed]
  10. Regulation of CYP 2 A 5 induction by porphyrinogenic agents in mouse primary hepatocytes. Salonpää, P., Kottari, S., Pelkonen, O., Raunio, H. Naunyn Schmiedebergs Arch. Pharmacol. (1997) [Pubmed]
  11. Photoaffinity labeling of protoporphyrinogen oxidase, the molecular target of diphenylether-type herbicides. Camadro, J.M., Matringe, M., Thome, F., Brouillet, N., Mornet, R., Labbe, P. Eur. J. Biochem. (1995) [Pubmed]
  12. Photochemical degradation of acifluorfen in aqueous solution. Vulliet, E., Emmelin, C., Scrano, L., Bufo, S.A., Chovelon, J.M., Meallier, P., Grenier-Loustalot, M.F. J. Agric. Food Chem. (2001) [Pubmed]
  13. Oxidative stress in cucumber (Cucumis sativus L) seedlings treated with acifluorfen. Gupta, I., Tripathy, B.C. Indian J. Biochem. Biophys. (2000) [Pubmed]
  14. Competitive interaction of three peroxidizing herbicides with the binding of [3H]acifluorfen to corn etioplast membranes. Varsano, R., Matringe, M., Magnin, N., Mornet, R., Scalla, R. FEBS Lett. (1990) [Pubmed]
  15. Effects of diphenyl ether herbicides on porphyrin accumulation by cultured hepatocytes. Jacobs, J.M., Sinclair, P.R., Gorman, N., Jacobs, N.J., Sinclair, J.F., Bement, W.J., Walton, H. J. Biochem. Toxicol. (1992) [Pubmed]
  16. Soil photolysis of herbicides in a moisture- and temperature-controlled environment. Graebing, P., Frank, M.P., Chib, J.S. J. Agric. Food Chem. (2003) [Pubmed]
  17. Protoporphyrinogen accumulation in cultured hepatocytes treated with the diphenyl ether herbicide, acifluorfen. Sinclair, P.R., Gorman, N., Walton, H.S., Sinclair, J.F., Jacobs, J.M., Jacobs, N.J. Cell. Mol. Biol. (Noisy-le-grand) (1994) [Pubmed]
  18. Cloning and expression of a Porphyromonas gingivalis gene for protoporphyrinogen oxidase by complementation of a hemG mutant of Escherichia coli. Kusaba, A., Ansai, T., Akifusa, S., Nakahigashi, K., Taketani, S., Inokuchi, H., Takehara, T. Oral Microbiol. Immunol. (2002) [Pubmed]
  19. Cometabolic degradation of acifluorfen by a mixed microbial culture. Andreoni, V., Colombo, M., Gennari, M., Nègre, M., Ambrosoli, R. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1994) [Pubmed]
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