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Chemical Compound Review

Raceophenidol     2,2-dichloro-N-[1,3- dihydroxy-1-(4...

Synonyms: Dexawin, Urophenyl, Fricol, Racefenicol, RACEPHENICOL, ...
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Disease relevance of Thiophenicol


Psychiatry related information on Thiophenicol


High impact information on Thiophenicol


Chemical compound and disease context of Thiophenicol


Biological context of Thiophenicol


Anatomical context of Thiophenicol


Associations of Thiophenicol with other chemical compounds


Gene context of Thiophenicol

  • To study the effect of CpG-ODN on erythroid cell maturation in vitro, we obtained primary EPO-responsive cells by treating mice with thiamphenicol (15 mg/g body weight) [29].
  • Isepamicin sulfate inhibited the enzyme activity (I(50) value, 2.1 mM; K(i) value, 1.7 mM), whereas thiamphenicol glisinat hydrochloride activated the G6PD dose dependently [30].
  • Investigation of the mt-mRNA decay after thiamphenicol treatment indicated that three transcripts (ND2, ND3 and Cyt. b) are significantly stabilized after inhibition of mitochondrial translation [31].
  • The in vitro activity of thiamphenicol and of 11 comparative drugs against 397 recently isolated antibiotic-resistant and/or invasive pneumococci and 52 multiply-resistant MRSA including 2 VISA strains was determined [32].
  • Introduction of the mexMN into the hypersensitive cells possessing oprM, but not into cells not possessing oprM, resulted in elevated MICs of chloramphenicol and thiamphenicol [33].

Analytical, diagnostic and therapeutic context of Thiophenicol


  1. Single-dose thiamphenicol for chancroid. Latif, A.S., Lencioni, R., Crocchiolo, P., Esposito, R. Lancet (1982) [Pubmed]
  2. Effects of thiamphenicol and chloramphenicol in inhibiting Neisseria gonorrhoeae isolates. Duck, P.D., Dillon, J.R., Eidus, L. Antimicrob. Agents Chemother. (1978) [Pubmed]
  3. Norfloxacin versus thiamphenicol for treatment of uncomplicated gonorrhea in Rwanda. Bogaerts, J., Martinez Tello, W., Verbist, L., Piot, P., Vandepitte, J. Antimicrob. Agents Chemother. (1987) [Pubmed]
  4. In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol. Syriopoulou, V.P., Harding, A.L., Goldmann, D.A., Smith, A.L. Antimicrob. Agents Chemother. (1981) [Pubmed]
  5. Reversal of rapid eye movement sleep without atonia by chloramphenicol. Aguilar-Roblero, R., Arankowsky, G., Drucker-Colin, R., Morrison, A.R., Bayon, A. Brain Res. (1984) [Pubmed]
  6. Isolation and characterization of the erythroid progenitor cell: CFU-E. Nijhof, W., Wierenga, P.K. J. Cell Biol. (1983) [Pubmed]
  7. Onset of erythropoietin response in murine erythroid colony-forming units: assignment to early S-phase in a specific cell generation. Landschulz, K.T., Boyer, S.H., Noyes, A.N., Rogers, O.C., Frelin, L.P. Blood (1992) [Pubmed]
  8. Inhibition of mitochondrial protein synthesis promotes increased stability of nuclear-encoded respiratory gene transcripts. Chrzanowska-Lightowlers, Z.M., Preiss, T., Lightowlers, R.N. J. Biol. Chem. (1994) [Pubmed]
  9. Induced stabilization of the transmembrane potential of Drosophila cells by heat shock and periodic applications of chloramphenicol. Behnel, H.J., Weckbart, G. J. Cell. Sci. (1987) [Pubmed]
  10. Evaluation of antibiotic susceptibilities of three rickettsial species including Rickettsia felis by a quantitative PCR DNA assay. Rolain, J.M., Stuhl, L., Maurin, M., Raoult, D. Antimicrob. Agents Chemother. (2002) [Pubmed]
  11. Characterization of chloramphenicol and florfenicol resistance in Escherichia coli associated with bovine diarrhea. White, D.G., Hudson, C., Maurer, J.J., Ayers, S., Zhao, S., Lee, M.D., Bolton, L., Foley, T., Sherwood, J. J. Clin. Microbiol. (2000) [Pubmed]
  12. Comparative study of treatment of uncomplicated gonorrhea with thiamphenicol and cefotaxime. Notowicz, A., Stolz, E., van Klingeren, B., van der Hoek, J., de Hoop, D., den Boer, M.S. Sexually transmitted diseases. (1984) [Pubmed]
  13. Treatment of infection due to penicillinase-producing Neisseria gonorrhoeae with oral thiamphenicol and with oral lymecycline. Latif, A.S., Marowa, E., Mason, P.R., Sithole, J., Tambo, J., Dhamu, F., Paraiwa, E. Sexually transmitted diseases. (1986) [Pubmed]
  14. Immunological enhancement in the pathogenesis of pyelonephritis. Miller, T.E., Burnham, S., North, J.D. Clin. Exp. Immunol. (1976) [Pubmed]
  15. Comparative effect of thiamphenicol glycinate, thiamphenicol glycinate N-acetylcysteinate, amoxicillin plus clavulanic acid, ceftriaxone and clarithromycin on pulmonary clearance of Haemophilus influenzae in an animal model. Drago, L., Fassina, M.C., Mombelli, B., De Vecchi, E., Lombardi, A., Gismondo, M.R. Chemotherapy. (2000) [Pubmed]
  16. Salient features of thiamphenicol: review of clinical pharmacokinetics and toxicity. Ferrari, V. Sexually transmitted diseases. (1984) [Pubmed]
  17. Plasmid patterns and in-vitro susceptibility of penicillinase-producing Neisseria gonorrhoeae with emphasis on thiamphenicol: results of surveillance in The Netherlands. van Klingeren, B., van Wijngaarden, L.J., Dessens-Kroon, M. Sexually transmitted diseases. (1984) [Pubmed]
  18. Fusobacterium nucleatum Apoptosis-inducing Outer Membrane Protein. Kaplan, C.W., Lux, R., Huynh, T., Jewett, A., Shi, W., Haake, S.K. J. Dent. Res. (2005) [Pubmed]
  19. Embryonic development and mitochondrial function. 2. Thiamphenicol induced embryotoxicity. Bass, R., Oerter, D. Naunyn Schmiedebergs Arch. Pharmacol. (1977) [Pubmed]
  20. Hemopoiesis during thiamphenicol treatment. I. Stimulation of stem cells during eradication of intermediate cell stages. Goris, H., Loeffler, M., Bungart, B., Schmitz, S., Nijhof, W. Exp. Hematol. (1989) [Pubmed]
  21. Bone marrow aplasia and thiamphenicol. De Renzo, A., Formisano, S., Rotoli, B. Haematologica (1981) [Pubmed]
  22. A rapid gas chromatographic determination of thiamphenicol in plasma and amniotic fluid. Plomp, T.A., Maes, R.A., Thiery, M. J. Chromatogr. (1976) [Pubmed]
  23. The effect of thiamphenicol on the production of immature red blood cells under anaemic conditions. Nijhof, W., Wierenga, P.K., Kardaun, S. Br. J. Haematol. (1977) [Pubmed]
  24. Cooperative and antagonistic interactions of peptidyl-tRNA and antibiotics with bacterial ribosomes. Contreras, A., Vázquez, D. Eur. J. Biochem. (1977) [Pubmed]
  25. In vitro activity of chloramphenicol and thiamphenicol analogs. Neu, H.C., Fu, K.P. Antimicrob. Agents Chemother. (1980) [Pubmed]
  26. In-vitro antibacterial activity of Sch 25393, a fluorinated analogue of thiamphenicol. Marca, G., Mattina, R., Dubini, F., Cocuzza, G. J. Antimicrob. Chemother. (1984) [Pubmed]
  27. Mechanism of glutathione-dependent dechlorination of chloramphenicol and thiamphenicol by cytosol of rat liver. Martin, J.L., Gross, B.J., Morris, P., Pohl, L.R. Drug Metab. Dispos. (1980) [Pubmed]
  28. Simultaneous analysis of thiamphenicol and its prodrug thiamphenicol glycinate in human plasma and urine by high performance liquid chromatography: application to pharmacokinetic study. Chen, X., Yang, B., Ni, L., Wang, G. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  29. Interferon-gamma mediates suppression of erythropoiesis but not reduced red cell survival following CpG-ODN administration in vivo. Thawani, N., Tam, M., Chang, K.H., Stevenson, M.M. Exp. Hematol. (2006) [Pubmed]
  30. Effects of some antibiotics on activity of glucose-6-phosphate dehydrogenase from human erythrocytes in vitro and effect of isepamicin sulfate on activities of antioxidant enzymes in rat erythrocytes. Ozmen, I., Küfrevioğlu, O.I., Gul, M. Drug and chemical toxicology. (2005) [Pubmed]
  31. Differential stability of mitochondrial mRNA in HeLa cells. Piechota, J., Tomecki, R., Gewartowski, K., Szczesny, R., Dmochowska, A., Kudła, M., Dybczyńska, L., Stepien, P.P., Bartnik, E. Acta Biochim. Pol. (2006) [Pubmed]
  32. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. Marchese, A., Debbia, E.A., Tonoli, E., Gualco, L., Schito, A.M. Journal of chemotherapy (Florence, Italy) (2002) [Pubmed]
  33. Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa. Mima, T., Sekiya, H., Mizushima, T., Kuroda, T., Tsuchiya, T. Microbiol. Immunol. (2005) [Pubmed]
  34. Changes in activities and isozyme patterns of glycolytic enzymes during erythroid differentiation in vitro. Nijhof, W., Wierenga, P.K., Staal, G.E., Jansen, G. Blood (1984) [Pubmed]
  35. Peritoneal transfer of thiamphenicol during peritoneal dialysis. Furman, K.I., Koornhof, H.J., Kilroe-Smith, T.A., Landless, R., Robinson, R.G. Antimicrob. Agents Chemother. (1976) [Pubmed]
  36. Single-dose treatment of uncomplicated gonorrhea in men with intramuscular and oral thiamphenicol. Panikabutra, K., Ariyarit, C., Chitwarakorn, A., Soonthararak, A., Saensanoh, C. Sexually transmitted diseases. (1984) [Pubmed]
  37. Thiamphenicol for treatment of salpingitis. Vige, P.M., Henrion, R.M. Sexually transmitted diseases. (1984) [Pubmed]
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