Disease relevance of Thiophenicol

• Single-dose thiamphenicol for chancroid [1].
• Effects of thiamphenicol and chloramphenicol in inhibiting Neisseria gonorrhoeae isolates [2].
• Norfloxacin versus thiamphenicol for treatment of uncomplicated gonorrhea in Rwanda [3].
• Of the three Haemophilus strains which were resistant to chloramphenicol, thiamphenicol, and the analogs, two contained less than 10% of the chloramphenicol acetyltransferase activity of the strains which were resistant to only chloramphenicol and thiamphenicol [4].
• The analogs were also more active than were chloramphenicol and thiamphenicol against chloramphenicol-resistant enteric bacteria, including six strains of Escherichia coli, seven strains of Klebsiella pneumoniae, and two strains of Enterobacter cloacae [4].

Psychiatry related information on Thiophenicol

• Thiamphenicol (TAP), a CAP analogue that does not reduce neuronal firing frequency during REM sleep, was used as a control drug [5].

High impact information on Thiophenicol

• The average CFU-E concentration in spleens from mice 4 d after the thiamphenicol-treatment was 10% [6].
• Generation I CFU-E, which produce mainly 32-cell erythroid colonies, were isolated in 82% average purity from spleens of thiamphenicol-treated anemic animals via differential centrifugation [7].
• A concomitant up-regulation in the activity of the only known respiratory transcript binding protein, cytochrome c oxidase L-form transcript binding protein (COLBP), was also noted in thiamphenicol-treated cells, demonstrating a potential mechanism for the increased transcript protection [8].
• At the same concentration, thiamphenicol (TAP) induces only a small reversible depolarization by less than 30% within 120 min [9].
• We found that R. felis is susceptible to doxycycline, rifampin, thiamphenicol, and fluoroquinolones but not to gentamicin, erythromycin, amoxicillin, or trimethoprim-sulfamethoxazole [10].

Chemical compound and disease context of Thiophenicol

• Florfenicol, a veterinary fluorinated analog of thiamphenicol, is approved for treatment of bovine respiratory pathogens in the United States. However, florfenicol resistance has recently emerged among veterinary Escherichia coli isolates incriminated in bovine diarrhea [11].
• The frequency of postgonococcal urethritis among male patients was 34.1% after thiamphenicol and 39.5% after cefotaxime treatment [12].
• Seventy-five men with gonococcal urethritis were treated with a single oral dose of thiamphenicol, and 88 men with this infection were treated with two 1.5-g oral doses of lymecycline taken 12 hr apart [13].
• The role of the immune response in pyelonephritis was investigated by manipulation of the host's immune capacity using the immunosuppressive drugs 6-mercaptopurine, cyclophosphamide and thiamphenicol [14].
• Comparative effect of thiamphenicol glycinate, thiamphenicol glycinate N-acetylcysteinate, amoxicillin plus clavulanic acid, ceftriaxone and clarithromycin on pulmonary clearance of Haemophilus influenzae in an animal model [15].

Biological context of Thiophenicol

• Salient features of thiamphenicol: review of clinical pharmacokinetics and toxicity [16].
• Susceptibility to thiamphenicol was tested, and plasmids were characterized for 1925 strains of penicillinase-producing Neisseria gonorrhoeae (PPNG) isolated in The Netherlands in 1981 and 1982 [17].
• Studies on the systemic bioavailability in humans of 2.5 g of thiamphenicol given orally showed mean peak levels in plasma of 16.1-18.6 micrograms/ml after about 2 hr, and plasma concentrations of thiamphenicol of greater than 2 micrograms/ml for approximately 17-20 hr [16].
• We used a new gene-inactivation vector conferring thiamphenicol resistance (pHS31) to construct a mutant deficient in one of the homologs, aim1 [18].
• Embryonic development and mitochondrial function. 2. Thiamphenicol induced embryotoxicity [19].

Anatomical context of Thiophenicol

• Hemopoiesis during thiamphenicol treatment. I. Stimulation of stem cells during eradication of intermediate cell stages [20].
• Bone marrow aplasia and thiamphenicol [21].
• A rapid gas chromatographic determination of thiamphenicol in plasma and amniotic fluid [22].
• The effect of thiamphenicol on the production of immature red blood cells under anaemic conditions [23].
• The lower-affinity bindings (dissociation constants Kd = 6.4 micronM and Kd = 1.5 micronM for thiamphenicol and chloramphenicol respectively) are due to the ribosomes bearing nascent peptides on the A-site [24].

Associations of Thiophenicol with other chemical compounds

• In vitro activity of chloramphenicol and thiamphenicol analogs [25].
• We evaluated the in vitro antimicrobial activity of Sch 24893, Sch 25298, and Sch 25393, three novel analogs of chloramphenicol and thiamphenicol [4].
• In-vitro antibacterial activity of Sch 25393, a fluorinated analogue of thiamphenicol [26].
• Mechanism of glutathione-dependent dechlorination of chloramphenicol and thiamphenicol by cytosol of rat liver [27].
• Simultaneous analysis of thiamphenicol and its prodrug thiamphenicol glycinate in human plasma and urine by high performance liquid chromatography: application to pharmacokinetic study [28].

Gene context of Thiophenicol

• To study the effect of CpG-ODN on erythroid cell maturation in vitro, we obtained primary EPO-responsive cells by treating mice with thiamphenicol (15 mg/g body weight) [29].
• Isepamicin sulfate inhibited the enzyme activity (I(50) value, 2.1 mM; K(i) value, 1.7 mM), whereas thiamphenicol glisinat hydrochloride activated the G6PD dose dependently [30].
• Investigation of the mt-mRNA decay after thiamphenicol treatment indicated that three transcripts (ND2, ND3 and Cyt. b) are significantly stabilized after inhibition of mitochondrial translation [31].
• The in vitro activity of thiamphenicol and of 11 comparative drugs against 397 recently isolated antibiotic-resistant and/or invasive pneumococci and 52 multiply-resistant MRSA including 2 VISA strains was determined [32].
• Introduction of the mexMN into the hypersensitive cells possessing oprM, but not into cells not possessing oprM, resulted in elevated MICs of chloramphenicol and thiamphenicol [33].

Analytical, diagnostic and therapeutic context of Thiophenicol

• The procedure included a four-day pretreatment of bled mice with the antibiotic thiamphenicol, a recovery period of 3 1/2 days, followed by centrifugal elutriation and Percoll density gradient centrifugation of the spleen cells [34].
• Peritoneal transfer of thiamphenicol during peritoneal dialysis [35].
• Group B received 2.5 g of thiamphenicol, with 500 mg administered intramuscularly just after oral administration of 2 g [36].
• After treatment with thiamphenicol, 10.9% of patients had diarrhea [12].
• Treatment on the day of surgery was the same for both groups: 1.5 g of iv thiamphenicol immediately after laparoscopy and 0.75 g im 12 hr later [37].

References