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Gene Review

ADAM23  -  ADAM metallopeptidase domain 23

Homo sapiens

Synonyms: ADAM 23, Disintegrin and metalloproteinase domain-containing protein 23, MDC-3, MDC3, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3
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Disease relevance of ADAM23


High impact information on ADAM23

  • In this work we show that the disintegrin-like domain of ADAM 23 produced in Escherichia coli and immobilized on culture dishes promotes attachment of different human cells of neural origin, such as neuroblastoma cells (NB100 and SH-S(y)5(y)) or astrocytoma cells (U373 and U87 MG) [3].
  • ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism [3].
  • ADAM 23 (a disintegrin and metalloproteinase domain)/MDC3 (metalloprotease, disintegrin, and cysteine-rich domain) is a member of the disintegrin family of proteins expressed in fetal and adult brain [3].
  • Analysis of ADAM 23 binding to integrins revealed a specific interaction with alphavbeta3, mediated by a short amino acid sequence present in its putative disintegrin loop [3].
  • The methylation status of the ADAM23 CpG island, which showed promoter activity, correlated inversely with its expression [1].

Biological context of ADAM23


Anatomical context of ADAM23

  • ADAM23 mRNA was expressed in normal stomach tissue, but not in the majority of GC cell lines without homozygous deletion of this gene [1].

Associations of ADAM23 with chemical compounds


Other interactions of ADAM23


Analytical, diagnostic and therapeutic context of ADAM23

  • In this paper, we report the cloning and sequence analysis of two novel additional members of this family, which we have termed MDC2 and MDC3 [5].


  1. ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation. Takada, H., Imoto, I., Tsuda, H., Nakanishi, Y., Ichikura, T., Mochizuki, H., Mitsufuji, S., Hosoda, F., Hirohashi, S., Ohki, M., Inazawa, J. Oncogene (2005) [Pubmed]
  2. ADAM23 methylation and expression analysis in brain tumors. Costa, F.F., Colin, C., Shinjo, S.M., Zanata, S.M., Marie, S.K., Sogayar, M.C., Camargo, A.A. Neurosci. Lett. (2005) [Pubmed]
  3. ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism. Cal, S., Freije, J.M., López, J.M., Takada, Y., López-Otín, C. Mol. Biol. Cell (2000) [Pubmed]
  4. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. Poindexter, K., Nelson, N., DuBose, R.F., Black, R.A., Cerretti, D.P. Gene (1999) [Pubmed]
  5. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. Sagane, K., Ohya, Y., Hasegawa, Y., Tanaka, I. Biochem. J. (1998) [Pubmed]
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