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Gene Review

DDX58  -  DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Homo sapiens

Synonyms: DEAD box protein 58, DKFZp434J1111, FLJ13599, RIG-1, RIG-I, ...
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Disease relevance of DDX58


High impact information on DDX58


Biological context of DDX58


Anatomical context of DDX58


Associations of DDX58 with chemical compounds


Other interactions of DDX58

  • Evidently, a cellular RNA helicase, retinoic acid-inducible gene I (RIG-I), and a cellular kinase, phosphatidylinositol-3 kinase (PI3K), are required for flavivirus-induced IRF-3 and NF-kappaB activation, respectively [15].

Analytical, diagnostic and therapeutic context of DDX58


  1. Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. Li, K., Chen, Z., Kato, N., Gale, M., Lemon, S.M. J. Biol. Chem. (2005) [Pubmed]
  2. Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells. Liu, P., Jamaluddin, M., Li, K., Garofalo, R.P., Casola, A., Brasier, A.R. J. Virol. (2007) [Pubmed]
  3. NAK-Associated Protein 1 Participates in Both the TLR3 and the Cytoplasmic Pathways in Type I IFN Induction. Sasai, M., Shingai, M., Funami, K., Yoneyama, M., Fujita, T., Matsumoto, M., Seya, T. J. Immunol. (2006) [Pubmed]
  4. The IFN-Independent Response to Virus Particle Entry Provides a First Line of Antiviral Defense That Is Independent of TLRs and Retinoic Acid-Inducible Gene I. Paladino, P., Cummings, D.T., Noyce, R.S., Mossman, K.L. J. Immunol. (2006) [Pubmed]
  5. Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus. Mibayashi, M., Mart??nez-Sobrido, L., Loo, Y.M., C??rdenas, W.B., Gale, M., Garc??a-Sastre, A. J. Virol. (2007) [Pubmed]
  6. Identification and sequence analysis of the promoter for the leukocyte integrin beta-subunit (CD18): a retinoic acid-inducible gene. Agura, E.D., Howard, M., Collins, S.J. Blood (1992) [Pubmed]
  7. Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20. Lin, R., Yang, L., Nakhaei, P., Sun, Q., Sharif-Askari, E., Julkunen, I., Hiscott, J. J. Biol. Chem. (2006) [Pubmed]
  8. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. Cheng, Y., Lotan, R. J. Biol. Chem. (1998) [Pubmed]
  9. Utilization of the human genome sequence localizes human papillomavirus type 16 DNA integrated into the TNFAIP2 gene in a fatal cervical cancer from a 39-year-old woman. Einstein, M.H., Cruz, Y., El-Awady, M.K., Popescu, N.C., DiPaolo, J.A., van Ranst, M., Kadish, A.S., Romney, S., Runowicz, C.D., Burk, R.D. Clin. Cancer Res. (2002) [Pubmed]
  10. Sexual function and erection capability among young men with spina bifida. Sandler, A.D., Worley, G., Leroy, E.C., Stanley, S.D., Kalman, S. Developmental medicine and child neurology. (1996) [Pubmed]
  11. DNA replication under the Rigi Kulm. EMBO workshop on 'Molecular Biology of DNA replication', Weggis, Switzerland, 8-13 September 1996. Van der Vliet, P.C. Biochim. Biophys. Acta (1997) [Pubmed]
  12. Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2. Imaizumi, T., Aratani, S., Nakajima, T., Carlson, M., Matsumiya, T., Tanji, K., Ookawa, K., Yoshida, H., Tsuchida, S., McIntyre, T.M., Prescott, S.M., Zimmerman, G.A., Satoh, K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  13. Antiproliferative effect of carotenoids on human colon cancer cells without conversion to retinoic acid. Onogi, N., Okuno, M., Matsushima-Nishiwaki, R., Fukutomi, Y., Moriwaki, H., Muto, Y., Kojima, S. Nutrition and cancer. (1998) [Pubmed]
  14. Alteration of midkine expression in the ischemic brain of humans. Wada, M., Kamata, M., Aizu, Y., Morita, T., Hu, J., Oyanagi, K. J. Neurol. Sci. (2002) [Pubmed]
  15. Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activation. Chang, T.H., Liao, C.L., Lin, Y.L. Microbes Infect. (2006) [Pubmed]
  16. Erectile dysfunction under age 40: etiology and role of contributing factors. Karadeniz, T., Topsakal, M., Aydogmus, A., Basak, D. ScientificWorldJournal (2004) [Pubmed]
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