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Gene Review

OpmnVgp003  -  polyhedrin

Orgyia pseudotsugata multiple nucleopolyhedrovirus

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Disease relevance of OpmnVgp003


High impact information on OpmnVgp003


Chemical compound and disease context of OpmnVgp003


Biological context of OpmnVgp003

  • A probable regulatory element was identified which is common to the 5' flanking region of all hypertranscribed late genes (polyhedrin and 10K proteins) which have been examined in baculoviruses [2].
  • A fragment containing this gene was cloned, mapped, subcloned and the nucleotide sequence of a 1.3 kb fragment was determined which contained the entire polyhedrin reading frame and some flanking sequences [2].
  • A recombinant baculovirus was generated that encodes the signal peptide, the precursor region and the extracellular part of the mature protein, under the control of the promotor for polyhedrin [7].

Anatomical context of OpmnVgp003

  • Differences in PPBP characteristics between nuclear extracts from Sf21 and from Bm5 (Bombyx mori) cell line suggested that additional factors may be involved in the interaction of PPBP with the polyhedrin promoter [4].

Analytical, diagnostic and therapeutic context of OpmnVgp003

  • The m.o.i. had little influence on the final rates of BV production and the time of detection of p39 and polyhedrin on Western blots [8].


  1. The nucleotide sequence of the polyhedrin gene region from the multicapsid baculovirus of Orgyia pseudotsugata. Leisy, D., Rohrmann, G., Beaudreau, G. Virology (1986) [Pubmed]
  2. Location and nucleotide sequence of the Orgyia pseudotsugata single nucleocapsid nuclear polyhedrosis virus polyhedrin gene. Leisy, D., Nesson, M., Pearson, M., Rohrmann, G., Beaudreau, G. J. Gen. Virol. (1986) [Pubmed]
  3. Selection of a nucleopolyhedrovirus for control of Spodoptera frugiperda (Lepidoptera: Noctuidae): structural, genetic, and biological comparison of four isolates from the Americas. Escribano, A., Williams, T., Goulson, D., Cave, R.D., Chapman, J.W., Caballero, P. J. Econ. Entomol. (1999) [Pubmed]
  4. An unusual 30-kDa protein binding to the polyhedrin gene promoter of Autographa californica nuclear polyhedrosis virus. Burma, S., Mukherjee, B., Jain, A., Habib, S., Hasnain, S.E. J. Biol. Chem. (1994) [Pubmed]
  5. DNA replication promotes high-frequency homologous recombination during Autographa californica multiple nuclear polyhedrosis virus infection. Martin, D.W., Weber, P.C. Virology (1997) [Pubmed]
  6. Characterization of canine herpesvirus glycoprotein C expressed by a recombinant baculovirus in insect cells. Xuan, X., Maeda, K., Mikami, T., Otsuka, H. Virus Res. (1996) [Pubmed]
  7. Characterization of recombinant E-cadherin (uvomorulin) expressed in insect cells. Herrenknecht, K., Kemler, R. J. Cell Sci. Suppl. (1993) [Pubmed]
  8. Characterization of the infection cycle of the Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus in Lymantria dispar cells. Bradford, M.B., Blissard, G.W., Rohrmann, G.F. J. Gen. Virol. (1990) [Pubmed]
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