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Gene Review

CCNB2  -  cyclin B2

Homo sapiens

Synonyms: G2/mitotic-specific cyclin-B2, HsT17299
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Disease relevance of CCNB2

  • In a series of 38 primary colorectal cancers, we detected in five tumors (13%) an accumulation of cyclin B1, which was neither related to mRNA overexpression nor to mutation within the coding region, and in five other tumors (13%) a 2-10-fold increase of cyclin B2 mRNA which was not related to gene amplification [1].
  • In 94.7% of the samples this quotient correctly distinguished non-small cell lung cancer from normal lung tissue, suggesting the RAGE/cyclin-B2 quotient as a potential means for diagnosis of lung cancer [2].
  • A dominant-negative form of NF-YA effectively inhibited the cyclin B2 promoter activity, and NF-Y was found to bind three conserved CCAAT boxes in the cyclin B2 promoter in colorectal adenocarcinoma cells [3].

High impact information on CCNB2

  • Equally, directing cyclin B2 to the cytoplasm with the NH(2) terminus of cyclin B1 confers the broader properties of cyclin B1 [4].
  • Although the cytoplasmic retention signal region is outside the cyclin box, its sequence is well conserved in human cyclin B2, and is both necessary and sufficient to keep cyclin B2 in the cytoplasm [5].
  • Thus, N-terminal fragments of cyclin A containing little more than the destruction box and its surroundings are indestructible. p34cdc2 binding also appears to be required for the destruction of cyclin B2 [6].
  • We show that the expression of cyclin B1 overlaps the expression of cyclin B2 in the mature testis, but not vice versa [7].
  • Cyclin B1 can be found both on intracellular membranes and free in the cytoplasm, in contrast to cyclin B2, which is membrane-associated [7].

Biological context of CCNB2

  • In contrast to cyclin B1, cyclin B2 does not relocate to the nucleus at prophase, but becomes uniformly distributed throughout the cell [8].
  • Both male and female cyclin B2-null mice were fertile, which was unexpected in view of the high levels and distinct patterns of expression of cyclin B2 during spermatogenesis [7].
  • Together with the recently described mouse cdc25C promoter, human cyclin B2 is the second identified gene which solely requires a CHR for its cell cycle regulation [9].
  • Phosphopeptide analysis identified Ser53 as the major in vitro phosphorylation site for cyk in cyclin B2 [10].
  • At first, protein levels of both cyclin Bs were examined by immunoblotting, revealing that immature oocytes had only CB2, at a level comparable to 1/20 to 1/40 of that detected in first metaphase oocytes [11].

Anatomical context of CCNB2


Associations of CCNB2 with chemical compounds


Physical interactions of CCNB2


Other interactions of CCNB2


Analytical, diagnostic and therapeutic context of CCNB2


  1. Overexpression of B-type cyclins alters chromosomal segregation. Sarafan-Vasseur, N., Lamy, A., Bourguignon, J., Pessot, F.L., Hieter, P., Sesboüé, R., Bastard, C., Frébourg, T., Flaman, J.M. Oncogene (2002) [Pubmed]
  2. Discrimination of human lung neoplasm from normal lung by two target genes. Hofmann, H.S., Hansen, G., Burdach, S., Bartling, B., Silber, R.E., Simm, A. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  3. NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma. Park, S.H., Yu, G.R., Kim, W.H., Moon, W.S., Kim, J.H., Kim, D.G. Clin. Cancer Res. (2007) [Pubmed]
  4. The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus. Draviam, V.M., Orrechia, S., Lowe, M., Pardi, R., Pines, J. J. Cell Biol. (2001) [Pubmed]
  5. The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. Pines, J., Hunter, T. EMBO J. (1994) [Pubmed]
  6. Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2. Stewart, E., Kobayashi, H., Harrison, D., Hunt, T. EMBO J. (1994) [Pubmed]
  7. Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Brandeis, M., Rosewell, I., Carrington, M., Crompton, T., Jacobs, M.A., Kirk, J., Gannon, J., Hunt, T. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus. Jackman, M., Firth, M., Pines, J. EMBO J. (1995) [Pubmed]
  9. Three CCAAT-boxes and a single cell cycle genes homology region (CHR) are the major regulating sites for transcription from the human cyclin B2 promoter. Wasner, M., Haugwitz, U., Reinhard, W., Tschöp, K., Spiesbach, K., Lorenz, J., Mössner, J., Engeland, K. Gene (2003) [Pubmed]
  10. Characterization and physiological importance of a novel cell cycle regulated protein kinase in Xenopus laevis oocytes that phosphorylates cyclin B2. Derua, R., Stevens, I., Waelkens, E., Fernandez, A., Lamb, N., Merlevede, W., Goris, J. Exp. Cell Res. (1997) [Pubmed]
  11. Analysis of the roles of cyclin B1 and cyclin B2 in porcine oocyte maturation by inhibiting synthesis with antisense RNA injection. Kuroda, T., Naito, K., Sugiura, K., Yamashita, M., Takakura, I., Tojo, H. Biol. Reprod. (2004) [Pubmed]
  12. Regulation of p34cdc2 protein kinase activity by phosphorylation and cyclin binding. Nigg, E.A., Gallant, P., Krek, W. Ciba Found. Symp. (1992) [Pubmed]
  13. Functional association of TGF-beta receptor II with cyclin B. Liu, J.H., Wei, S., Burnette, P.K., Gamero, A.M., Hutton, M., Djeu, J.Y. Oncogene (1999) [Pubmed]
  14. Tyrosine phosphorylation of p34cdc2 is regulated by protein phosphatase 2A in growing immature Xenopus oocytes. Rime, H., Jessus, C., Ozon, R. Exp. Cell Res. (1995) [Pubmed]
  15. The tumour suppressor protein p53 can repress transcription of cyclin B. Krause, K., Wasner, M., Reinhard, W., Haugwitz, U., Dohna, C.L., Mössner, J., Engeland, K. Nucleic Acids Res. (2000) [Pubmed]
  16. Decreased mRNA transcripts of M-phase promoting factor and its regulators in the testes of infertile men. Lin, Y.M., Teng, Y.N., Chung, C.L., Tsai, W.C., Lin, Y.H., Lin, J.S., Kuo, P.L. Hum. Reprod. (2006) [Pubmed]
  17. Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas. Moreno-Bueno, G., Sánchez-Estévez, C., Cassia, R., Rodríguez-Perales, S., Díaz-Uriarte, R., Domínguez, O., Hardisson, D., Andujar, M., Prat, J., Matias-Guiu, X., Cigudosa, J.C., Palacios, J. Cancer Res. (2003) [Pubmed]
  18. Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones. Frade, J.M. J. Cell. Sci. (2000) [Pubmed]
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