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Gene Review

XPR1  -  xenotropic and polytropic retrovirus...

Homo sapiens

Synonyms: Protein SYG1 homolog, SYG1, X-receptor, X3, XR, ...
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Disease relevance of XPR1


High impact information on XPR1


Biological context of XPR1


Anatomical context of XPR1

  • Finally, we show that PYY stimulates growth in Y1R-expressing gut epithelial cells that is dependent on EGFR TK activity [5].
  • Treatment of female rats with estrogen in vivo decreased the levels of Y1R mRNA in the whole pituitary gland [6].
  • Further, they support a role for PYY and the Y1R in regulating growth in human colonic epithelium [5].

Associations of XPR1 with chemical compounds

  • Estrogen up-regulates Y1R expression through ERalpha [1].
  • In conclusion, MCF-7 cells express a functional Y1R coupled to both Ca(2+) and cAMP pathways [1].
  • Cycloheximide decreased basal Y1R mRNA expression; however, it did not affect its increase by estrogen [1].
  • Because NPY also modulates LH release directly, we examined steroid regulation of Y1R expression in the female rat anterior pituitary [6].
  • For phenobarbital tablets, a 3 X 3 X 3 factorial experiment was run [7].

Other interactions of XPR1

  • Truncated, branched, and/or cyclic analogues of neuropeptide Y: importance of the pancreatic peptide fold in the design of specific Y2 receptor ligands [2].


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